Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Healthy Mushroom Capsules Ingredients & Drug Interactions

by Terra Origin

Healthy Mushroom Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Healthy Mushroom Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Healthy Mushroom Capsules is a dietary supplement by Terra Origin with 5 active ingredients. Its ingredients are commonly taken for immune support, antioxidant support, general wellness/tonic.Based on those ingredients, 502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom, Powder, Chaga Mushroom, Powder, Hericium erinaceus Mushroom, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Healthy Mushroom Capsules by Terra Origin

Ask about any prescription or over-the-counter medication and we check it for interactions with Healthy Mushroom Capsules by Terra Origin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Healthy Mushroom Capsules by Terra Origin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains five active mushroom powders: chaga, maitake, cordyceps, lion's mane (hericium erinaceus), and reishi. Each is included as a powder form of the whole mushroom fruiting body or mycelium.

The capsules also contain two inactive ingredients — pullulan (a capsule binder) and rice husk concentrate (a filler) — which play no therapeutic role.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support and memory with natural energy.
  • We looked for evidence on: Memory, Cognitive function, Fatigue, Chronic fatigue syndrome (CFS), Athletic performance, Motor function — and 1 related terms.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue.
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence we hold on these ingredients is very limited. For chaga, maitake, lion's mane, and cordyceps, we have no reliable evidence yet supporting their use for the conditions they're marketed for — whether that's heart health, diabetes, cognitive function, athletic performance, or others.

Cordyceps is actually rated as possibly ineffective for athletic performance. Because the data for these mushrooms is still developing, we can't say whether this product will deliver the benefits the label claims.

The evidence, ingredient by ingredient Chaga Maitake Mushroom Cordyceps Lion's Mane Mushroom Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All four checked mushrooms are generally well tolerated as foods, but when taken as concentrated supplements, our safety data are limited. The most common side effects are gastrointestinal — diarrhea, constipation, nausea, and stomach discomfort occur in small numbers of trial participants.

One person taking maitake developed a rash that cleared on its own. There is one case report of liver inflammation possibly linked to cordyceps, though it's unclear whether cordyceps or a contaminant caused it.

Chaga in high amounts can damage kidneys because it's rich in oxalate; two cases of kidney failure and one of acute kidney injury have been reported with excessive use. Regarding pregnancy and breastfeeding: not enough safety data exists for any of the four checked mushrooms — chaga, maitake, cordyceps, and lion's mane — so concentrated supplements are best avoided during pregnancy and lactation.

We have no safety information on file for reishi.

Side effects, ingredient by ingredient Chaga Maitake Mushroom Cordyceps Lion's Mane Mushroom Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Reishi Mushroom, Chaga, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 502 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check blood thinners like warfarin (Coumadin) and antiplatelet drugs — maitake especially may increase their effect, and the other mushrooms carry similar theoretical risks. Also check diabetes medications (blood sugar risks), blood pressure drugs (maitake may lower pressure further), and immune-suppressing medications.

If you take testosterone, note that cordyceps might have additive effects, though the clinical meaning is unclear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take a blood thinner, diabetes medication, blood pressure drug, or immune suppressant, you'll want to check your specific medications with our tool before starting this product — the interactions are documented and worth discussing with your pharmacist. Otherwise, these mushrooms are generally well tolerated, though the evidence for most claimed benefits isn't established yet.

Talk to your pharmacist or doctor if you're pregnant, breastfeeding, or have kidney concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Healthy Mushroom Capsules, straight from the product label.

Brand Terra Origin
Barcode (UPC) 857668007823
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 329122
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Healthy Mushroom Capsules by Terra Origin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
857668007823
IngredientAmount% DV
Chaga Mushroom, Powder350 mg--
Maitake Mushroom, Powder350 mg--
Cordyceps Mushroom, Powder350 mg--
Hericium erinaceus Mushroom, Powder350 mg--
Reishi Mushroom, Powder350 mg--

Other ingredients: Pullulan, Rice Husk Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Healthy Mushroom Capsules We combine five mushroom mycelia for potent immune support and energy combined with Lion's Mane nootropics to help support memory and motor function. Sourced from nature, these ingredients may act as a detoxifying agent and support immune response

Benefits Five types of mushroom mycelia Nootropics to support memory function.

General Statements

For more information, please visit Terraorigin.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Potent immune support Source of natural energy

USDA Organic Certified Organic by QAI.

Non GMO

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic

Storage

Warnings Store in a cool, dry place.

Precautions

Do not use if safety seal is broken or missing.

Suggested/Recommended/Usage/Directions

Suggested use As a dietary supplement take 1 serving (3 capsules) per day.

Brand IP Statement(s)

Copyright 2023 Terra Origin Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Healthy Mushroom Capsules by Terra Origin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Healthy Mushroom Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Healthy Mushroom Capsules by Terra Origin

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chaga Mushroom, Powder

Interacts with
327 drugs
350 mg per serving Form: Chaga Mushroom, Powder, Chaga Mushroom, Powder

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Chaga Mushroom, Powder monograph & interactions

Maitake Mushroom, Powder

Interacts with
260 drugs
350 mg per serving Form: Maitake Mushroom, Powder, Maitake Mushroom, Powder

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom, Powder monograph & interactions

Cordyceps Mushroom, Powder

Interacts with
249 drugs
350 mg per serving Form: Cordyceps Mushroom, Powder, Cordyceps Mushroom, Powder

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Mushroom, Powder monograph & interactions

Hericium erinaceus Mushroom, Powder

Interacts with
327 drugs
350 mg per serving Form: Hericium erinaceus Mushroom, Powder, Hericium erinaceus Mushroom, Powder, Hericium erinaceus Mushroom, Powder

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Hericium erinaceus Mushroom, Powder monograph & interactions

Reishi Mushroom, Powder

Interacts with
375 drugs
350 mg per serving Form: Reishi Mushroom, Powder, Reishi Mushroom, Powder, Reishi Mushroom, Powder

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom, Powder monograph & interactions

Other (inactive) ingredients: Pullulan, Rice Husk Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Healthy Mushroom Capsules by Terra Origin Drug Interactions

Want to check YOUR meds against Healthy Mushroom Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
502Drugs
494 Moderate 8 Minor

Ingredients driving the most interactions

Reishi Mushroom, Powder 375
Chaga Mushroom, Powder 327
Hericium erinaceus Mushroom, Powder 327
Maitake Mushroom, Powder 260
Cordyceps Mushroom, Powder 249

Individual Drug Interactions

The ingredients in Healthy Mushroom Capsules interact with 502 drugs. Click any drug to see the details.

5 of the 5 ingredients in Healthy Mushroom Capsules interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom, Powder Chaga Mushroom, Powder Hericium erinaceus Mushroom, Powder Maitake Mushroom, Powder Cordyceps Mushroom, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Healthy Mushroom Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom, Powder3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom, Powder full monograph & interactions

Chaga Mushroom, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Mushroom, Powder full monograph & interactions

Hericium erinaceus Mushroom, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Hericium erinaceus Mushroom, Powder full monograph & interactions

Maitake Mushroom, Powder3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom, Powder full monograph & interactions

Cordyceps Mushroom, Powder3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mushroom, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Healthy Mushroom Capsules, from the product label.

Terra Origin

See all Terra Origin products
Name
Terra Origin Inc.
Street Address
330 Oser Avenue
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
631-300-2306
Web Address
www.TerraOrigin.com
Pharmacist Counseling Corner

Healthy Mushroom Capsules by Terra Origin: Common Questions

Does Healthy Mushroom Capsules by Terra Origin interact with any medications?
Yes. Based on its ingredients, Healthy Mushroom Capsules has a known interaction with 502 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Healthy Mushroom Capsules contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood thinner?
Not without checking first. Maitake has documented evidence it may increase warfarin's blood-thinning effect — one patient's INR spiked after a week of use. The other mushrooms carry theoretical risks with blood thinners too. Run your exact medication through our checker on this page, then talk with your pharmacist.
What's the most common side effect?
Gastrointestinal upset — diarrhea, nausea, constipation, or stomach discomfort. These were uncommon in the trials we have data for, and some people found symptoms improved by taking it with food.
Can I take this if I'm pregnant?
The safety data for chaga, maitake, cordyceps, and lion's mane during pregnancy aren't sufficient — there isn't enough information to know either way. Talk with your doctor or pharmacist for personalized advice. We have no safety data on file for reishi.
Does this actually work for what it claims?
The evidence we hold doesn't support most of the marketed uses yet. For all four checked mushrooms, the scientific evidence is still limited and rated insufficient to make a reliable claim.
Is there anything in here besides the mushroom powders?
The capsules contain pullulan and rice husk concentrate, which are inactive ingredients — fillers and binders. They don't play a therapeutic role.
What about the reishi mushroom in this product?
We hold no interaction data for reishi, so we can't tell you whether it interacts with your medications. Your pharmacist can help you research it separately or advise based on what you take.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Healthy Mushroom Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Healthy Mushroom Capsules label
Go deeper

The Full Monographs Behind Healthy Mushroom Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Healthy Mushroom Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
  8. Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
  9. Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed

See these in context on the Chaga monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Cordyceps 14 references
  1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
  3. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
  4. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  5. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
  6. Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
  7. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
  8. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
  9. Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
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See these in context on the Cordyceps monograph →

Lion's Mane Mushroom 6 references
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  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Reishi Mushroom 17 references
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  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
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  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
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See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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