Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Hericium Erinaceus SAP Ingredients & Drug Interactions

by NFH

Hericium Erinaceus SAP label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hericium Erinaceus SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hericium Erinaceus SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hericium Erinaceus SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with Hericium Erinaceus SAP by NFH — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Hericium Erinaceus SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane mushroom (Hericium erinaceus), a fungal extract sometimes called SAP. The capsule itself also holds inactive ingredients — magnesium stearate, hypromellose, and purified water — which are binders and fillers that hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support immune system and provide antioxidant support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for lion's mane mushroom on the claims it's often marketed for — Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment — is insufficient to rate in our data. That means the studies so far aren't robust enough to say whether it works.

If you're considering it for one of these reasons, talk it over with your doctor about what the current science actually shows and whether it makes sense for your situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane is generally well tolerated as a food. In supplement form, long-term safety hasn't been well studied, so caution is warranted if you plan to take it regularly.

The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash. During pregnancy and breastfeeding, there isn't enough safety data, so it's best to avoid it — talk with your doctor or pharmacist if you're in either situation and wondering whether to use it.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (including over-the-counter aspirin), diabetes medications, or immunosuppressants. Lion's mane carries moderate-level interaction risks with all three types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane mushroom is a single-ingredient supplement that's often tried for cognitive and immune support, though the evidence for those uses isn't established in our data. The main caution is its moderate interaction risk with blood thinners, diabetes drugs, and immunosuppressants.

If you take any of those, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hericium Erinaceus SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711001955
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273307
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hericium Erinaceus SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
856711001955
IngredientAmount% DV
Lion's Mane500 mg--

Other ingredients: Magnesium Stearate, Hypromellose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Hericium Erinaceus SAP is used in herbal medicine to support the immune system. Hericium Erinaceus SAP provides antioxidant support.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Note: Polysaccharide and beta-glucan content may vary from lot to lot. Label shows tested value.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO and vegan friendly.

This product is non-GMO and vegan friendly.

Color, size and smell may vary from one lot to another.

Made in Canada

Suggested/Recommended/Usage/Directions

Directions for use: Adults: Take 1 capsule daily with food or as directed by your healthcare practitioner. To avoid digestive upset, take with food / a meal. Immune support: Use for a minimum of 4 weeks to see beneficial effects.

Precautions

Cautions and warnings: Consult a healthcare practitioner prior to use if you are pregnant or breast-feeding.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Note: Product is sensitive to humidity and heat; keep in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Hot-water extract Lion's mane

FDA Statement of Identity

Dietary Supplement

General Statements

NPN 80049550

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hericium Erinaceus SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hericium Erinaceus SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hericium Erinaceus SAP by NFH

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lion's Mane

Interacts with
327 drugs
500 mg per serving Form: Beta-Glucans, Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hericium Erinaceus SAP by NFH Drug Interactions

Want to check YOUR meds against Hericium Erinaceus SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane 327

Individual Drug Interactions

The ingredients in Hericium Erinaceus SAP interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hericium Erinaceus SAP interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in Hericium Erinaceus SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hericium Erinaceus SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Rue Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1 866 510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

Hericium Erinaceus SAP by NFH: Common Questions

Does Hericium Erinaceus SAP by NFH interact with any medications?
Yes. Based on its ingredients, Hericium Erinaceus SAP has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hericium Erinaceus SAP contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lion's mane safe to take if I'm pregnant or breastfeeding?
No — there isn't enough safety data for either pregnancy or breastfeeding. It's best to avoid it in both situations. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding and want to explore your options.
What side effects might I experience?
The most common ones reported are gastrointestinal discomfort, nausea, and skin rash. Lion's mane is generally well tolerated as a food, but long-term safety in supplement form hasn't been well studied.
Will lion's mane help with memory or cognitive function?
The evidence isn't established in our data — we can't rate whether it works for those purposes based on the studies we hold. If cognitive health is your goal, ask your doctor what the current science supports and whether this is right for you.
Can I take this with my blood thinner?
Not without checking first. Lion's mane may increase bleeding risk when combined with blood thinners and antiplatelet drugs. Talk with your doctor or pharmacist before starting — they can assess your individual risk.
What exactly is in this capsule?
The active ingredient is lion's mane mushroom extract. The capsule also contains magnesium stearate, hypromellose, and purified water as inactive ingredients to hold it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hericium Erinaceus SAP is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hericium Erinaceus SAP label
Go deeper

The Full Monographs Behind Hericium Erinaceus SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Hericium Erinaceus SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team