Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

ImmunoStim Ingredients & Drug Interactions

by HoltraCeuticals

ImmunoStim label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ImmunoStim against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ImmunoStim is a dietary supplement by HoltraCeuticals with 6 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 674 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe vera, Reishi Mushroom powder, BGF-Immune. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ImmunoStim by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with ImmunoStim by HoltraCeuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ImmunoStim by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ImmunoStim contains six active ingredients: reishi mushroom powder, maitake mushroom extract, beta-glucans (labeled as BGF-Immune), olive leaf extract, arabinogalactan powder, and aloe vera. These are paired with two inactive ingredients—microcrystalline cellulose and a vegetable capsule—that serve as filler and capsule material.

The first five ingredients are traditionally used to support immune function, while aloe vera is included for its various wellness applications. The product delivers these in capsule form for convenience.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Acne — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Burns — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Constipation — rated "Possibly Effective" (Aloe) (Natural Medicines).

The evidence for most of these ingredients is thin or not yet established. Beta-glucans stand out with "Likely Effective" ratings for dyslipidemia (unhealthy cholesterol) and coronary heart disease.

Aloe vera shows "Possibly Effective" evidence for acne, obesity, diabetes, psoriasis, burns, and constipation. For the others—reishi mushroom, maitake mushroom, olive leaf extract, and arabinogalactan—the evidence we hold rates them as having insufficient reliable evidence to determine if they work for their labeled purposes (altitude sickness, allergic rhinitis, hay fever, common cold, and others).

Reishi mushroom rates as "Possibly Ineffective" for high cholesterol.

The evidence, ingredient by ingredient Reishi Mushroom Maitake Mushroom Beta-glucans Olive Larch Arabinogalactan Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom, maitake mushroom, beta-glucans, and larch arabinogalactan are generally well tolerated as foods or supplements short-term, though long-term safety data are sparse. Common side effects with reishi include dizziness, dry mouth, nausea, rash, and stomach upset; maitake may cause diarrhea and stomach pain; beta-glucans and arabinogalactan can cause bloating and flatulence.

Olive leaf extract is generally tolerated and may cause headache or stomach discomfort. Aloe vera is well tolerated topically but carries real risk with oral use, especially high doses or long-term—it can cause abdominal pain, cramps, severe diarrhea, and dangerous potassium loss.

During pregnancy, reishi mushroom and maitake mushroom supplements should be avoided due to insufficient safety data. Aloe latex is possibly unsafe in pregnancy because it may stimulate the uterus and acts as a strong laxative.

For beta-glucans, olive leaf extract, and arabinogalactan, not enough safety data exists; talk with your doctor or pharmacist before use in pregnancy. Breastfeeding carries similar caution for all five of these ingredients—data are too limited to know they're safe.

Side effects, ingredient by ingredient Reishi Mushroom Maitake Mushroom Beta-glucans Olive Larch Arabinogalactan Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Maitake Mushroom, Aloe, Reishi Mushroom, Larch Arabinogalactan, Beta-glucans.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 674 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking ImmunoStim if you take digoxin (Lanoxin) or any heart medication—aloe vera poses a Major risk. Also double-check if you take blood pressure medications (antihypertensives), diabetes drugs (antidiabetes medications), blood thinners (anticoagulant or antiplatelet drugs including warfarin), diuretics, immunosuppressants, stimulant laxatives, or drugs metabolized by the liver enzyme CYP1A2 (Moderate or Minor severity depending on the type).

No interactions are documented in our data for olive leaf extract, the one ingredient we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

ImmunoStim is built around mushroom extracts and plant compounds traditionally linked to immunity, though the evidence that they work for specific conditions is limited or absent in our data. Beta-glucans do have solid evidence for cholesterol and heart health.

If you take any heart, blood pressure, diabetes, blood-thinning, immunosuppressant, or diuretic medication, or if you're pregnant or breastfeeding, talk with your own doctor or pharmacist before starting this product—aloe vera and several other ingredients carry real interactions or safety concerns in these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ImmunoStim, straight from the product label.

Brand HoltraCeuticals
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 273666
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ImmunoStim by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
IngredientAmount% DV
Reishi Mushroom powder200 mg--
Maitake Mushroom extract30 mg--
BGF-Immune500 mg--
Olive leaf extract400 mg--
Arabinogalactan, Powder400 mg--
Aloe vera100 mg--

Other ingredients: Micro Crystalline Cellulose, Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 6 capsules daily with meals. Can betaken throughout the day or as directed by a health professional.

Storage

Store in a cool, dry place with the lid tightly closed.

Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

For re-order visit Holtraceuticals.com

Formulation

Made in a GMP compliant facility in USA

Promotes immune function

No artificial colors, artificial flavors, milk or milk derivatives, or sodium added.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Holtorf Medical Group, Inc. Center for hormone imbalance, hypothyroidism and fatigue

Formula

BGF-Immune

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ImmunoStim by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ImmunoStim label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ImmunoStim by HoltraCeuticals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Reishi Mushroom powder

Interacts with
375 drugs
200 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom powder monograph & interactions

Maitake Mushroom extract

Interacts with
260 drugs
30 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom extract monograph & interactions

BGF-Immune

Interacts with
293 drugs
500 mg per serving Form: Beta 1,3 Glucan

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

BGF-Immune monograph & interactions

Olive leaf extract

No known
interactions
400 mg per serving Form: Oleuropein

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Arabinogalactan, Powder

Interacts with
121 drugs
400 mg per serving Form: Larch

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

Arabinogalactan, Powder monograph & interactions

Aloe vera

Interacts with
461 drugs
100 mg per serving Form: Polysaccharides

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Aloe vera monograph & interactions

Other (inactive) ingredients: Micro Crystalline Cellulose, Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

ImmunoStim by HoltraCeuticals Drug Interactions

Want to check YOUR meds against ImmunoStim?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
674Drugs
1 Major 522 Moderate 151 Minor

Ingredients driving the most interactions

Aloe vera 461
Reishi Mushroom powder 375
BGF-Immune 293
Maitake Mushroom extract 260
Arabinogalactan, Powder 121

Individual Drug Interactions

The ingredients in ImmunoStim interact with 674 drugs. Click any drug to see the details.

5 of the 6 ingredients in ImmunoStim interact with drugs. Each result below shows which ingredient is responsible. Aloe vera Reishi Mushroom powder BGF-Immune Maitake Mushroom extract Arabinogalactan, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in ImmunoStim with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Reishi Mushroom powder3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom powder full monograph & interactions

BGF-Immune2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
BGF-Immune full monograph & interactions

Maitake Mushroom extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom extract full monograph & interactions

Arabinogalactan, Powder1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Arabinogalactan, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ImmunoStim, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Name
Kent Holtorf, M.D. and the Holtorf Medical Group
City
El Segundo
State
CA
Phone Number
310-375-2705
Web Address
HoltraCeuticals.com
Pharmacist Counseling Corner

ImmunoStim by HoltraCeuticals: Common Questions

Does ImmunoStim by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, ImmunoStim has a known interaction with 674 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ImmunoStim contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ImmunoStim if I'm pregnant?
Not without talking to your doctor first. Reishi and maitake mushroom supplements should be avoided in pregnancy due to limited safety data. Aloe vera is possibly unsafe because it may stimulate the uterus and cause strong laxative effects. The other ingredients also lack enough pregnancy safety data. Ask your own healthcare provider whether this product is right for you during pregnancy.
What's the most common side effect I might notice?
It depends on which ingredient affects you most. Reishi can cause dizziness, dry mouth, nausea, or stomach upset. Maitake and arabinogalactan may cause digestive upset—diarrhea, cramping, or bloating. Most people tolerate these ingredients well, but if you notice any of these, stop and check with your pharmacist.
Does this actually boost immunity?
The evidence isn't there yet in our data. Reishi, maitake, and the others are traditionally used for immunity, but we don't hold reliable evidence that they work for that purpose. Beta-glucans do have solid evidence for lowering cholesterol and supporting heart health, so if that's your goal, there's something here—but for general immunity support, the science hasn't caught up.
Is aloe vera in this product safe to take by mouth?
Topical aloe gel is generally safe, but oral aloe—especially the latex—carries real risks with repeated use: abdominal pain, diarrhea, and potassium loss are common concerns, and serious complications like dangerous low potassium are possible with high doses or long-term use. This product contains aloe, so take it as directed and don't exceed the dose.
Can I take this with my blood pressure or diabetes medication?
Not without checking first. Reishi mushroom, maitake mushroom, beta-glucans, and aloe vera all can lower blood pressure or blood sugar further, which may be risky. Talk with your own doctor or pharmacist before combining ImmunoStim with those medications—they need to know what you're taking and adjust monitoring or dosing if needed.
What's in here besides the active ingredients?
Two inactive ingredients: microcrystalline cellulose (a common filler) and a vegetable capsule shell. No other additives are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ImmunoStim is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ImmunoStim label
Go deeper

The Full Monographs Behind ImmunoStim’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

ImmunoStim's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 87 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Maitake Mushroom 8 references
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See these in context on the Maitake Mushroom monograph →

Beta-glucans 11 references
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  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
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  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
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Olive 2 references
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See these in context on the Olive monograph →

Larch Arabinogalactan 8 references
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  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
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See these in context on the Larch Arabinogalactan monograph →

Aloe 41 references
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  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
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  6. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
  7. Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
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  12. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
  13. Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
  14. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
  15. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
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  20. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
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  22. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
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  26. Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
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  31. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
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  33. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
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  37. Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
  38. Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
  39. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  40. Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
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See these in context on the Aloe monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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