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Dietary supplement

IndoleMax Ingredients & Drug Interactions

by VitaMonk

IndoleMax label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking IndoleMax against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

IndoleMax is a dietary supplement by VitaMonk with 1 active ingredient. Its ingredients are commonly taken for estrogen and hormone balance support, breast and cervical health, prostate health.Based on those ingredients, 294 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indole-3-Carbinol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against IndoleMax by VitaMonk

Ask about any prescription or over-the-counter medication and we check it for interactions with IndoleMax by VitaMonk — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of IndoleMax by VitaMonk

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

IndoleMax contains one active ingredient: indole-3-carbinol, a compound found naturally in cruciferous vegetables like broccoli and Brussels sprouts. The product also includes inactive ingredients—vegetable cellulose, white rice flour, and rice extract—which are used as the capsule material and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Indole-3-carbinol product and its label doesn't state a use — see Indole-3-carbinol's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for indole-3-carbinol is not yet established in the data we hold. We have insufficient reliable evidence to rate its effectiveness for breast cancer, ovarian cancer, cervical dysplasia, liver disease, colorectal cancer, or fibromyalgia.

That doesn't mean it doesn't work—it means the clinical trials to prove it aren't complete or strong enough yet.

The evidence, ingredient by ingredient Indole-3-carbinol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Indole-3-carbinol from food is likely fine, but supplement doses at higher concentrations are less well studied and should be used cautiously. The most common side effects from oral use are diarrhea, nausea, rash, tremor, and unsteadiness.

Higher doses have been linked to imbalance and tremor; one person taking 400 mg twice daily developed these symptoms after 10 days, which improved when the dose was cut in half. Because of possible hormone effects and limited safety data, concentrated supplements should be avoided during pregnancy.

Safety data isn't on file for this ingredient during breastfeeding, so supplement use is not recommended while nursing. Talk with your doctor or pharmacist about your individual situation if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Indole-3-carbinol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Indole-3-carbinol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 294 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking IndoleMax, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk)—indole-3-carbinol may increase bleeding. Also check if you're on estrogen therapy (Moderate risk) or any drugs that depend on the CYP1A2 enzyme to be cleared from your body (Moderate risk), as this supplement may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

IndoleMax may be worth considering if you're interested in the potential benefits of indole-3-carbinol, but the evidence for its effectiveness is still being researched. However, you should be cautious if you take blood thinners, antiplatelet drugs, estrogen therapy, or medications metabolized by the CYP1A2 pathway.

Before adding it to your routine, check with your doctor or pharmacist to make sure it won't interfere with your current medications or health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about IndoleMax, straight from the product label.

Brand VitaMonk
Barcode (UPC) B01N66Y20F
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242151
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for IndoleMax by VitaMonk, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
B01N66Y20F
IngredientAmount% DV
Indole-3-Carbinol250 mg--

Other ingredients: Vegetable Cellulose, White Rice Flour, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions & Recommended Use: As a dietary supplement, take 1 capsule 1-2 times daily or as directed by your healthcare practitioner.

Precautions

Warning: Keep out of reach of children. Do not use if pregnant, nursing, or under the age of 18.

Do not use if pregnant, nursing, or under the age of 18.

Consult with a health care professional if you have or suspect a medical condition, or before beginning any new dietary supplement. If you experience any adverse reactions please discontinue use and contact your health care professional. Indole-3-carbinol affects estrogen levels. Caution is advised, as estrogen has a significant impact on bodily functions. Hormone balance be tested (via simple blood test) before regular consumption. Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice 100% Premium Quality Satisfaction Guaranteed

Formula

Premium Indole-3-Carbinol

Formulation

Balances estrogen levels

FDA Statement of Identity

Dietary Supplement

General Statements

To get 15% off your next purchase, visit www.vitamonk.com/thanks

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

IndoleMax by VitaMonk label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

IndoleMax label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in IndoleMax by VitaMonk

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Indole-3-Carbinol

Interacts with
294 drugs
250 mg per serving

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...

Indole-3-Carbinol monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, White Rice Flour, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

IndoleMax by VitaMonk Drug Interactions

Want to check YOUR meds against IndoleMax?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
294Drugs
294 Moderate

Ingredients driving the most interactions

Indole-3-Carbinol 294

Individual Drug Interactions

The ingredients in IndoleMax interact with 294 drugs. Click any drug to see the details.

1 of the 1 ingredient in IndoleMax interact with drugs. Each result below shows which ingredient is responsible. Indole-3-Carbinol

Each ingredient & the kinds of drugs it affects

For each ingredient in IndoleMax with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for IndoleMax, from the product label.

VitaMonk

See all VitaMonk products
Name
VitaMonk
Web Address
www.vitamonk.com/Thanks
Pharmacist Counseling Corner

IndoleMax by VitaMonk: Common Questions

Does IndoleMax by VitaMonk interact with any medications?
Yes. Based on its ingredients, IndoleMax has a known interaction with 294 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
IndoleMax contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is indole-3-carbinol, and where does it come from?
Indole-3-carbinol is a compound found naturally in cruciferous vegetables like broccoli and Brussels sprouts. IndoleMax concentrates it into a supplement form in much higher amounts than you'd get from eating those vegetables.
Can I take IndoleMax if I'm on birth control?
Not without checking first. Indole-3-carbinol may interfere with how estrogen therapy—including birth control—works in your body. Talk with your doctor or pharmacist before starting this supplement if you're on any form of estrogen-based medication.
What are the most common side effects?
The most common are diarrhea, nausea, rash, tremor, and unsteadiness. At higher doses, imbalance and tremor are more likely. If you notice these symptoms, especially unsteadiness, lower your dose and talk with your pharmacist or doctor.
Is it safe to take while breastfeeding?
No safety data is on file for indole-3-carbinol during breastfeeding, so supplement use is not recommended. Talk with your doctor or pharmacist if you're nursing and interested in taking it.
Does IndoleMax actually work for cancer prevention or other conditions?
The evidence isn't established yet. We have insufficient reliable evidence to rate it for breast cancer, ovarian cancer, cervical dysplasia, liver disease, colorectal cancer, or fibromyalgia. That means the research is still ongoing.
Can I take IndoleMax with my blood thinner?
Not without checking with your doctor first. Indole-3-carbinol may increase your bleeding risk if you're on anticoagulants or antiplatelet drugs like warfarin or aspirin. Get cleared before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

IndoleMax label
Go deeper

The Full Monographs Behind IndoleMax’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph →
Sources

Sources & How We Checked

IndoleMax's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Indole-3-carbinol 9 references
  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
  3. He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
  4. Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
  5. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  6. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
  7. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
  8. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  9. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

See these in context on the Indole-3-carbinol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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