Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Iso-100 Vanilla Cream Ingredients & Drug Interactions

by Dymatize Nutrition

Iso-100 Vanilla Cream label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Iso-100 Vanilla Cream against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Iso-100 Vanilla Cream is a dietary supplement by Dymatize Nutrition with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 296 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Iso-100 Vanilla Cream by Dymatize Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Iso-100 Vanilla Cream by Dymatize Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Iso-100 Vanilla Cream by Dymatize Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Iso-100 Vanilla Cream is a whey protein powder with 2 active ingredients: sodium and calcium. The product is 100% hydrolyzed whey protein isolate — that is, whey that's been broken down into smaller pieces so your body can absorb it quickly.

The inactive ingredients include natural and artificial flavors, soybean oil, potassium chloride, sodium chloride, silicon dioxide, and sucralose; these are fillers, flavorings, and binders that make the powder mix and taste right.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dyspepsia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hypocalcemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hyperkalemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Kidney failure — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Corticosteroid-induced osteoporosis — rated "Likely Effective" (Calcium) (Natural Medicines).

Calcium in this product is well-established for preventing and treating weak bones (osteoporosis) and is also used to treat low calcium levels, high potassium, and indigestion. Sodium's main proven role is in cystic fibrosis, and it may help reduce kidney damage from the antibiotic amphotericin B.

However, the evidence for sodium in bipolar disorder and heart failure isn't strong enough to rate. Because this is a protein powder, the sodium and calcium content is modest — far below amounts used therapeutically — so don't expect this product alone to treat any of those conditions.

The evidence, ingredient by ingredient Sodium Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated at normal dietary amounts, but the safety notes warn that too much is linked to high blood pressure and heart strain. Avoid sodium supplements or very high intakes without talking to your doctor first — regular dietary sodium is fine.

Calcium is generally well tolerated at recommended doses, though high amounts can cause belching, constipation, diarrhea, and stomach upset. Very high calcium intake over time has raised some concern about kidney stones and, in rare cases, a serious skin condition called calciphylaxis.

For pregnancy and breastfeeding, both ingredients carry mixed safety data: calcium is listed as likely safe but also possibly unsafe depending on the source, and sodium is listed as both likely safe and possibly unsafe. Talk with your doctor or pharmacist about whether this product fits your individual pregnancy or breastfeeding plan.

Side effects, ingredient by ingredient Sodium Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Calcium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 296 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Iso-100, check with your doctor or pharmacist if you take any HIV integrase inhibitor (dolutegravir, elvitegravir, or raltegravir), as calcium cuts their blood levels — some need to be timed hours apart from this product. Blood pressure medications (antihypertensives), lithium, corticosteroids, thyroid hormone (levothyroxine), the heart drug sotalol, and any other sodium-containing or calcium-containing medications should also be reviewed.

If you've had intravenous ceftriaxone recently, ask before taking this product. No interactions are documented in our data for the whey protein isolate ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Iso-100 is a protein powder that works well for building muscle and recovering after exercise, but its sodium and calcium content can interact with several common medications — especially HIV drugs, thyroid medication, blood pressure pills, and lithium. If you take any prescription medications, check them against our interaction tool before adding this to your routine.

A conversation with your own doctor or pharmacist is your best move, especially if you're on heart, thyroid, or psychiatric medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Iso-100 Vanilla Cream, straight from the product label.

Brand Dymatize Nutrition
Barcode (UPC) 705016100163
Net contents 5 lbs; 2275 g
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 14677
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Iso-100 Vanilla Cream by Dymatize Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
28 Gram(s)
Maximum serving Sizes:
28 Gram(s)
Servings per container
81
UPC/BARCODE
705016100163
IngredientAmount% DV
Calories106 {Calories}--
Total Carbohydrates0 g--
Sugar0 g--
Total Fat0 g--
Protein25 g50%
Sodium50 mg2%
Cholesterol0 mg--
Calcium60 mg6%

Other ingredients: 100% Hydrolyzed Whey Protein Isolate, Natural and Artificial flavors, Soybean Oil, Potassium Chloride, Sodium Chloride, Silicon Dioxide, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

DYMATIZE ISO•100 derives its name from its protein source, 100% Whey Protein Isolate. Unless you are in the medical profession, you have probably never seen protein like this before. Most companies “claim” they use Whey Protein Isolate, but after one serving of Dymatize ISO•100 you can instantly see, taste and even feel the difference! Our Whey Protein Isolate has been processed to the zenith of perfection, 100% hydrolyzed and instantized and taken through no less than 5 quality controlled steps. Both lactose and fat have been removed from ISO•100, leaving you with nothing but the most easily digested, assimilated and most bio-available source of protein on the market. We know that maximum protein utilization is essential to aiding muscle recovery and maintaining a positive nitrogen balance, which is critical during periods of intense training. There is no higher standard of protein than ISO•100, so feel confident that you will be feeding your muscles to their fullest potential! Check the stats: each serving has an astonishing 25 grams protein, with “1” Carb & “0” Fat.~ Look closer. You will see that all this is in a serving size of about 28 grams, making ISO•100 90% protein by weight! Nothing out there matches our formula, nothing even comes close. The meticulous processing of Dymatize Whey Protein Isolate gives you “instant mixability” in its true form. You won’t believe how quickly Dymatize ISO•100 goes into solution. And, because of its ultra-purity and zero lactose~, Dymatize ISO•100 could be the easiest protein to digest on the market today.^ Don’t forget, with “0” carbohydrates~, Dymatize ISO•100 is perfect for low carb diets.^

(chart) 15 20 25 24 ISO-100 19 OTHERS PROTEIN GRAMS PER 28 GRAM SERVING (chart) 0 1 2 3 1 ISO-100 3 OTHERS CARB GRAMS PER 28 GRAM SERVING (chart) 0 5 10 15 20 25 25 ISO-100 3 EGG WHITES 8 BEEF FILET 7 TUNA 9 CHICKEN PROTEIN GRAMS PER 1 OUNCE SERVING

MANUFACTURED IN THE USA • EEC APPROVED • DYMATIZE ENTERPRISES, INC. • PLANT# 3005816913

(972) 732-1990

TYPICAL AMINO ACID PROFILE PER SERVING ESSENTIAL AMINO ACIDS (Molecular Drawing) Isoleucine 1,975 mg BCAA (Molecular Drawing) Leucine 2,825 mg BCAA (Molecular Drawing) Lysine 2,000 mg (Molecular Drawing) Methionine 425 mg (Molecular Drawing) Phenylalanine 650 mg (Molecular Drawing) Threonine 1,700 mg (Molecular Drawing) Tryptophan# 450 mg (Molecular Drawing) Valine 1,850 mg BCAA NON-ESSENTIAL AMINO ACIDS (Molecular Drawing) Alanine 1,100 mg (Molecular Drawing) Arginine 575 mg (Molecular Drawing) Aspartic Acid 2,350 mg (Molecular Drawing) Cystine 450 mg (Molecular Drawing) Glutamine & Precursors 4,450 mg (Molecular Drawing) Glycine 450 mg (Molecular Drawing) Histidine 440 mg (Molecular Drawing) Proline 1,550 mg (Molecular Drawing) Serine 1,225 mg (Molecular Drawing) Tyrosine 550 mg # Naturally occurring. Not added or manufactured.

NATURALLY & ARTIFICIALLY FLAVORED

The Highest Protein Percentage in its Class 25g of protein per serving 28g serving size X 100 = 90% Protein Take the protein percentage challenge. You will be amazed how other protein powders numbers add up in this equation.

Hydrolyzed 100% Whey Protein Isolate

FDA Disclaimer Statement

^These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

MANUFACTURED FREE OF BANNED SUBSTANCES IN A NSF GMP FOR SPORT(TM) REGISTERED FACILITY

MANUFACTURED IN A NSF GMP CERTIFIED FACILITY

QUALITY PURITY GUARANTEED TMB

Made in USA

GLUTEN-FREE

General

5028

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

PROTEIN 25g PER 28g SERVING CARBS 0 GRAMs FAT 0 GRAMS LACTOSE 0 GRAMS RATIO 90% PROTEIN

Nutritional Value per (28g/100g) 28g 100g Calories 443kJ/106kcal 1582kJ/379kcal Protein 25 grams 89 grams Carbohydrates 0 gram 2 grams Fat 0 gram 1 gram

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, add one heaping scoop to 4-8 oz. or 350ml of water, juice or milk. Mix for 15 seconds or until completely dispersed. For maximum results, take 2-3 servings daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Iso-100 Vanilla Cream by Dymatize Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Iso-100 Vanilla Cream label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Iso-100 Vanilla Cream by Dymatize Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size28 Gram(s) Dosage formPowder Servings per container81 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 g per serving

Protein

25 g per serving

Sodium

Interacts with
205 drugs
50 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
60 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Other (inactive) ingredients: 100% Hydrolyzed Whey Protein Isolate, Natural and Artificial flavors, Soybean Oil, Potassium Chloride, Sodium Chloride, Silicon Dioxide, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Iso-100 Vanilla Cream by Dymatize Nutrition Drug Interactions

Want to check YOUR meds against Iso-100 Vanilla Cream?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
296Drugs
7 Major 287 Moderate 2 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in Iso-100 Vanilla Cream interact with 296 drugs. Click any drug to see the details.

2 of the 4 ingredients in Iso-100 Vanilla Cream interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Iso-100 Vanilla Cream with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Iso-100 Vanilla Cream, from the product label.

Dymatize Nutrition

See all Dymatize Nutrition products
Name
Dymatize Enterprises, LLC
Street Address
13737 N Stemmons FWY
City
Dallas
State
TX
ZipCode
75234
Phone Number
(888) 334-5326
Pharmacist Counseling Corner

Iso-100 Vanilla Cream by Dymatize Nutrition: Common Questions

Does Iso-100 Vanilla Cream by Dymatize Nutrition interact with any medications?
Yes. Based on its ingredients, Iso-100 Vanilla Cream has a known interaction with 296 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Iso-100 Vanilla Cream contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this a meal replacement?
No — Iso-100 is a protein powder designed to help with muscle recovery and building, not a complete meal. It contains protein, sodium, and calcium, but it's missing many other nutrients you'd get from a full meal.
Does calcium in this product affect how my thyroid medication works?
Yes, calcium can reduce how much levothyroxine your body absorbs, making it less effective. If you take thyroid medication, separate it from this product by at least 4 hours — take one in the morning and this product later, or vice versa.
Will this product help my bone health?
It contains some calcium, which is important for bones, but the amount in a protein powder is relatively modest — far below what's used to treat or prevent osteoporosis. You'd need to get most of your calcium from food sources or a dedicated calcium supplement for that purpose.
Is the sodium content a problem for blood pressure?
The amount of sodium in a serving is similar to what you'd get from food, so it's not a concern for most people eating a typical diet. However, if you take blood pressure medications or have been told to limit sodium, check the nutrition label and discuss it with your doctor before using this regularly.
Can I take this while pregnant?
The safety data we hold is mixed — both likely safe and possibly unsafe ratings appear in our records. You'll need to talk with your doctor or pharmacist about whether this specific product fits your pregnancy plan.
What are the side effects?
At normal amounts, the whey protein and ingredients are well tolerated. At very high calcium doses, some people report belching, constipation, diarrhea, or stomach upset, but a single serving of this powder isn't a high dose. Excess sodium over time may raise blood pressure and heart strain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Iso-100 Vanilla Cream label
Go deeper

The Full Monographs Behind Iso-100 Vanilla Cream’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Iso-100 Vanilla Cream's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 100 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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