L-Citrulline DL-Malate 2:1 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Citrulline DL-Malate 2:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Citrulline DL-Malate 2:1 is a dietary supplement by HR Supplements with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Citrulline DL-Malate 2:1 by HR Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline DL-Malate 2:1 by HR Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Citrulline DL-Malate 2:1 by HR Supplements
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — L-citrulline.
- The most serious interaction on file is rated Moderate.
- For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Citrulline DL-Malate 2:1, straight from the product label.
| Brand | HR Supplements |
|---|---|
| Barcode (UPC) | 818132902815 |
| Net contents | 500 Gram(s); 1.1 lbs |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 287084 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Citrulline DL-Malate 2:1 by HR Supplements, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
High Quality & Pure Ingredients
Pure Powder
This is a non-gmo ingredient
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 3 rounded scoops (~3 grams) with 8-12 ounces of water or suitable beverage. Taken 30 minutes prior to workout and again immediately after for maximum results.
Carefully measure out suggested serving size using a microscale or the provided scoop Add to preferred beverage. Mix Well. Drink within 10-15 minutes. How to Use
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Precautions
WARNING: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
Allergens: This product contains NO soy, Dairy, Dairy byproducts, Eggs, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.
Re-seal zipper immediately after use to preserve freshness. Do not use or consume if seal is broken.
Storage
Storage: Store in a cool, dry place.
Seals/Symbols
Lab Tested For Purity and Quality
Lab Tested Packaged in USA
FDA Statement of Identity
Dietary Supplement
General Statements
For additional information & support please contact us at: 866-961-8378 or [email protected]
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Citrulline DL-Malate 2:1 by HR Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Citrulline DL-Malate 2:1 by HR Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Gram(s) Dosage formPowder Servings per container166 Amounts shown are per serving.
L-Citrulline DL-Malate
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline DL-Malate monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Citrulline DL-Malate 2:1 by HR Supplements Drug Interactions
L-Citrulline DL-Malate 2:1 contains a single active ingredient, and it has known interactions with 178 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against L-Citrulline DL-Malate 2:1?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Citrulline DL-Malate 2:1 interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Citrulline DL-Malate 2:1 interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate
Hydrochlorothiazide, ReserpineHydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2
How Hydrochlorothiazide, Reserpine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydrochlorothiazide, Reserpine interactionHydrochlorothiazide, SpironolactoneAldactazide, Aldactide 25, Aldactide 50, Spirozine
How Hydrochlorothiazide, Spironolactone interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydrochlorothiazide, Spironolactone interactionHydrochlorothiazide, TimololTimolide
How Hydrochlorothiazide, Timolol interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydrochlorothiazide, Timolol interactionHydrochlorothiazide, TriamtereneDyazide, Maxzide, Maxzide-25, Triamzide, Triazide
How Hydrochlorothiazide, Triamterene interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydrochlorothiazide, Triamterene interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydrochlorothiazide, Valsartan interactionHydroflumethiazideSaluron
How Hydroflumethiazide interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydroflumethiazide interactionHydroflumethiazide, ReserpineSalutensin, Salutensin-Demi
How Hydroflumethiazide, Reserpine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Hydroflumethiazide, Reserpine interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Iloprost interactionIndapamideLozide, Lozol
How Indapamide interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Indapamide interactionIrbesartanAprovel, Avapro
How Irbesartan interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Irbesartan interactionIrbesartan, HydrochlorothiazideCoAprovel
How Irbesartan, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Irbesartan, Hydrochlorothiazide interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Isosorbide Dinitrate, Hydralazine interactionIsradipineDynacirc CR
How Isradipine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Isradipine interactionLabetalolNormodyne, Trandate
How Labetalol interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Labetalol interactionLercanidipine HydrochlorideZanidip
How Lercanidipine Hydrochloride interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Lercanidipine Hydrochloride interactionLevamlodipineConjupri
How Levamlodipine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Levamlodipine interactionLisinoprilPrinivil, Qbrelis, Zestril
How Lisinopril interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Lisinopril interactionLosartan PotassiumCozaar
How Losartan Potassium interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Losartan Potassium interactionMacitentanOpsumit
How Macitentan interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Macitentan interactionMacitentan, TadalafilOpsynvi
How Macitentan, Tadalafil interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs, Phosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Macitentan, Tadalafil interactionMannitolBronchitol, Osmitrol
How Mannitol interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Mannitol interactionMecamylamineInversine
How Mecamylamine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Mecamylamine interactionMethazolamideNeptazane
How Methazolamide interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Methazolamide interactionMethyclothiazideAquatensen, Enduron
How Methyclothiazide interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Methyclothiazide interactionMethyclothiazide, PargylineEutron
How Methyclothiazide, Pargyline interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Methyclothiazide, Pargyline interactionMethyclothiazide, ReserpineDiutensen-R
How Methyclothiazide, Reserpine interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Methyclothiazide, Reserpine interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Methyldopa interactionMetolazoneDiulo, Mykrox, Zaroxolyn
How Metolazone interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Metolazone interactionMetoprololLopressor, Toprol XL
How Metoprolol interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Metoprolol interactionMinoxidilLoniten, Minoxidil, Rogaine
How Minoxidil interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Minoxidil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Citrulline DL-Malate 2:1 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline DL-Malate
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for L-Citrulline DL-Malate 2:1, from the product label.
HR Supplements
See all HR Supplements products- Name
- Guardian Wholesale
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Phone Number
- (866) 961-8378
L-Citrulline DL-Malate 2:1 by HR Supplements: Common Questions
Does L-Citrulline DL-Malate 2:1 by HR Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Citrulline DL-Malate 2:1 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Citrulline DL-Malate 2:1’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Citrulline DL-Malate 2:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC