Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Mr Hyde Intense Energy Pre Workout Watermelon Ingredients & Drug Interactions

by PS ProSupps

Mr Hyde Intense Energy Pre Workout Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mr Hyde Intense Energy Pre Workout Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mr Hyde Intense Energy Pre Workout Watermelon is a dietary supplement by PS ProSupps with 7 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 1,276 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Matrix, Agmatine Sulfate, L-Citrulline Aspartate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps

Ask about any prescription or over-the-counter medication and we check it for interactions with Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 14 of its 14 active ingredients.
  • “Caffeine Matrix” is a proprietary blend — the label gives one combined amount (419 mg) without saying how much of each component you get.
  • “Strength Matrix” is a proprietary blend — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.

Mr Hyde Intense Energy contains 14 active ingredients centered on stimulation and athletic performance. Three separate caffeine sources—Caffeine Anhydrous, Caffeine Citrate, and Infinergy—provide the backbone of the energy effect.

CarnoSyn (beta-alanine) supports muscle performance, while Creatine Nitrate aids strength and muscle function. For circulation and pump effects, you get L-Citrulline Aspartate and Agmatine Sulfate.

The formula also includes Yohimbe bark extract, Hordenine, N-Methyl L-Tyramine HCl, and Pikatropin (picamilon) as additional stimulant and performance-enhancing compounds. The inactive ingredients include soluble corn fiber, natural and artificial flavors, sucralose, silicon dioxide, and food coloring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: intense energy pre-workout athletic performance.
  • We looked for evidence on: Athletic performance, Mental alertness, Fatigue, Exercise-induced muscle soreness, Exercise-induced muscle breakdown, Muscle strength — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.

Caffeine is well established for mental alertness and athletic performance (both rated Likely Effective), and the product delivers it from three sources. Beta-alanine (CarnoSyn) shows Possibly Effective evidence for athletic and physical performance.

Creatine Nitrate is rated Possibly Effective for muscle strength and athletic performance. L-Citrulline is Possibly Effective for athletic performance.

For Yohimbe, Hordenine, N-methyltyramine, Agmatine, and Pikatropin, the evidence we hold shows ratings of Insufficient Reliable Evidence or no established effectiveness data. The stimulant ingredients in this product lack human research backing their advertised benefits.

The evidence, ingredient by ingredient Caffeine Yohimbe Hordenine N-methyltyramine Picamilon Beta-alanine Creatine L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate doses is typically well tolerated in healthy adults, though high doses carry rare serious risks including stroke. Common side effects include anxiety, insomnia, restlessness, tremors, nausea, and diarrhea.

Beta-alanine commonly causes harmless tingling and skin flushing, usually starting on the scalp within 20 minutes and lasting about an hour. Yohimbe can cause significant adverse effects—anxiety, agitation, headache, high blood pressure, rapid heart rate, tremors, and diarrhea—and can be unsafe in large doses.

Hordenine, N-methyltyramine, and Pikatropin have very limited human safety data; hordenine and N-methyltyramine theoretically carry stimulant risks including rapid heart rate and high blood pressure. Creatine may cause dehydration, muscle cramps, water retention, and gastrointestinal upset.

Agmatine's long-term safety is not well studied; short-term use appears well tolerated but can cause diarrhea, nausea, and indigestion. L-citrulline is generally well tolerated but may cause gastrointestinal discomfort or heartburn.

Side effects, ingredient by ingredient Caffeine Yohimbe Hordenine N-methyltyramine Picamilon Beta-alanine Creatine L-citrulline

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Yohimbe, Caffeine, L-citrulline, Hordenine, Agmatine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,277 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you use ephedrine or any stimulant drug (Major risk), monoamine oxidase inhibitors or MAOIs for depression, blood pressure medications, tricyclic antidepressants, antipsychotics like clozapine, seizure medications (phenobarbital or carbamazepine), sleep aids (pentobarbital), heart stress-test medications (dipyridamole), stomach acid medications (cimetidine), antibiotics (especially quinolones), or diabetes drugs. If you take any of these, do not use this product without talking to your pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant pre-workout designed for athletes and experienced supplement users—not a casual energy drink. If you take any blood pressure medication, antidepressant, diabetes drug, seizure medication, antibiotic, or sleep aid, check your specific medications with the tool below before using this product.

The caffeine alone can interact with many drugs, and yohimbe adds serious risks. Talk to your pharmacist before starting, especially if you have heart disease, high blood pressure, or anxiety.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mr Hyde Intense Energy Pre Workout Watermelon, straight from the product label.

Brand PS ProSupps
Barcode (UPC) 682055405568
Net contents 14.8 oz.; 420 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42660
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
60
UPC/BARCODE
682055405568
IngredientAmount% DV
L-Leucine500 mg--
Caffeine Anhydrous300 mg--
CarnoSyn2.5 Gram(s)--
Yohimbe bark extract2 mg--
Hordenine50 mg--
Caffeine Citrate50 mg--
Creatine Nitrate1 Gram(s)--
N-Methyl L-Tyramine HCl50 mg--
Rauwolfia vomitoria root extract2 mg--
Caffeine Matrix419 mg--
Strength Matrix5 Gram(s)--
L-Citrulline Aspartate500 mg--
Agmatine Sulfate500 mg--
Pikatropin50 mg--
Infinergy69 mg--
Intensity Matrix154 mg--

Other ingredients: soluble Corn Fiber, Natural & Artificial flavor, Sucralose, Calcium Silicate, Silicon Dioxide, FD&C Red #40, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

DO NOT USE IF PREGNANT OR NURSING.

CONSULT A PHYSICIAN OR LICENSED QUALIFIED HEALTH CARE PROFESSIONAL BEFORE USING THIS PRODUCT IF YOU HAVE, OR HAVE A FAMILY HISTORY OF HEART DISEASE, THYROID DISEASE, DIABETES, HIGH BLOOD PRESSURE, DEPRESSION OR OTHER PSYCHIATRIC CONDITION, GLAUCOMA, DIFFICULTY IN URINATING, PROSTATE ENLARGEMENT, OR SEIZURE DISORDER. DO NOT EXCEED RECOMMENDED SERVING. EXCEEDING RECOMMENDED SERVING MAY CAUSE ADVERSE HEALTH EFFECTS. DISCONTINUE USE AND CALL A PHYSICIAN OR LICENSED QUALIFIED HEALTH CARE PROFESSIONAL IMMEDIATELY IF YOU EXPERIENCE RAPID HEARTBEAT, DIZZINESS, SEVERE HEADACHE, SHORTNESS OF BREATH OR OTHER SIMILAR SYMPTOMS. INDIVIDUALS WHO ARE SENSITIVE TO THE EFFECTS OF CAFFEINE OR HAVE A MEDICAL CONDITION SHOULD CONSULT A LICENSED HEALTH CARE PROFESSIONAL BEFORE CONSUMING THIS PRODUCT. DO NOT USE THIS PRODUCT IF YOU ARE MORE THAN 15 POUNDS OVERWEIGHT. THE CONSUMER ASSUMES TOTAL LIABILITY IF THIS PRODUCT IS USED IN A MANNER INCONSISTENT WITH LABEL GUIDELINES. DO NOT USE FOR WEIGHT REDUCTION. THIS PRODUCT IS INTENDED FOR USE BY HEALTHY INDIVIDUALS ONLY.

KEEP OUT OF REACH OF CHILDREN.

TOO MUCH CAFFEINE MAY CAUSE NERVOUSNESS, IRRITABILITY, SLEEPLESSNESS AND OCCASIONALLY RAPID HEARTBEAT.

MANUFACTURED IN A FACILITY THAT PROCESSES MILK, EGG, SOY, WHEAT, AND SHELLFISH.

PLEASE REFER TO ADDITIONAL *WARNING.

Contains Soy Lecithin.

DO NOT CONSUME MRHYDE(TM) WITHIN 4 HOURS PRIOR TO BEDTIME. DO NOT TAKE ANY OTHER PRODUCTS THAT CONTAIN CAFFEINE OR ANY OTHER STIMULANTS WHILE TAKING MRHYDE(TM).

*WARNING: MRHYDE(TM) IS FOR ADVANCED EXERCISE AND SUPPLEMENT USERS ONLY. DO NOT EXCEED ONE SCOOP PRIOR TO EXERCISE UNDER ANY CIRCUMSTANCES.

FDA Disclaimer Statement

+ THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

Brand IP Statement(s)

prosupps(R) RESULTS...PERIOD!+

“THE DESCRIPTION OF MRHYDE(TM) AS AN ALMOST PREHUMAN CREATURE AND HIS ACTIONS THAT OCCUR WITHOUT THOUGHT, SUGGESTS THAT MRHYDE(TM) IS MORE ANIMAL THAN MAN” - SIR ROBERT STEVENSON, AUTHOR “DR JEKYLL AND MR HYDE”

FROM THE TRAINING JOURNAL OF THE LATE IFBB PRO ART ATWOOD COMES THE MOST EXTREME AND EFFECTIVE PRE-WORKOUT ON THE MARKET: ProSupps MRHYDE(TM). MRHYDE(TM) GIVES YOU A SERIOUS KICK IN THE A**!

CarnoSyn(R) trademark and patents owned by Natural Alternatives International, Inc., www.carnosyn.com.

NO3-T(R) is a Trademark of ThermoLife International & protected by US Patent Numbers 7,777,074 - 8,466,187 8,455,531 - 8,178,572 8,183,288

Seals/Symbols

PS(R)

AGMAPURE(R) Natural Agmatine Sulfate

CarnoSyn(R) Carnosine Synthesizer

GLUTEN FREE

CERTIFIED cGMP

NO3T(R) NITRATE TECHNOLOGY NO3-T.COM/PATENTS

MADE IN USA

General Statements

INTENSE ENERGY PRE WORKOUT+

> POTENT COMBINATION OF HIGH-POWERED THERMOGENIC COMPOUNDS+

> THREE STAGE ENERGY BLEND +

60 SERVINGS

NATURAL AND ARTIFICIAL FLAVOR

MANUFACTURED IN A cGMP FACILITY

{facebook} {twitter} {Instagram} FOLLOW US ON INSTAGRAM, FACEBOOK & TWITTER .

Formula

> L-CITRULLINE AND LEUCINE TO PREVENT MUSCLE CATABOLISM+

Contains Soy Lecithin.

LOADED WITH L-LEUCINE, EXPLOSIVE STIMULANT BLENDS AND THE NOVEL PUMP AGENT AGMATINE SULFATE, MRHYDE(TM) WILL SHATTER WEIGHT-TRAINING PLATEAUS. +

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE: AS A DIETARY SUPPLEMENT, MIX 1 SCOOP OF MRHYDE(TM) WITH 8 OZ OF COLD WATER. CONSUME 15 TO 30 MINUTES BEFORE EXERCISE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mr Hyde Intense Energy Pre Workout Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Caffeine Matrix

Interacts with
655 drugs
419 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Matrix monograph & interactions

Strength Matrix

5 Gram(s) per serving

Intensity Matrix

154 mg per serving

Other (inactive) ingredients: Soluble Corn Fiber, Natural & Artificial flavor, Sucralose, Calcium Silicate, Silicon Dioxide, FD&C Red #40, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps Drug Interactions

Want to check YOUR meds against Mr Hyde Intense Energy Pre Workout Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,276Drugs
17 Major 949 Moderate 310 Minor

Ingredients driving the most interactions

Caffeine Matrix 655
Agmatine Sulfate 258
L-Citrulline Aspartate 178

Individual Drug Interactions

The ingredients in Mr Hyde Intense Energy Pre Workout Watermelon interact with 1,276 drugs. Click any drug to see the details.

3 of the 7 ingredients in Mr Hyde Intense Energy Pre Workout Watermelon interact with drugs. Each result below shows which ingredient is responsible. Caffeine Matrix Agmatine Sulfate L-Citrulline Aspartate

Each ingredient & the kinds of drugs it affects

For each ingredient in Mr Hyde Intense Energy Pre Workout Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Matrix41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Matrix full monograph & all 41 interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

L-Citrulline Aspartate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Aspartate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mr Hyde Intense Energy Pre Workout Watermelon, from the product label.

PS ProSupps

See all PS ProSupps products
Name
PROSUPPS USA, LLC.
Street Address
601 Century Pkwy. Ste. 300
City
Allen
State
TX
ZipCode
75013
Web Address
www.prosupps.com
Pharmacist Counseling Corner

Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps: Common Questions

Does Mr Hyde Intense Energy Pre Workout Watermelon by PS ProSupps interact with any medications?
Yes. Based on its ingredients, Mr Hyde Intense Energy Pre Workout Watermelon has a known interaction with 1,276 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mr Hyde Intense Energy Pre Workout Watermelon contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the tingling feeling from this product?
That's beta-alanine (CarnoSyn), which commonly causes a harmless pins-and-needles sensation and skin flushing, usually on the scalp. It starts within 20 minutes, spreads across your body, and typically fades after about an hour. It's not dangerous, just a normal response to that ingredient.
Does this product actually work for athletic performance?
Caffeine is proven to boost mental alertness and athletic performance. Creatine and beta-alanine have evidence for athletic performance too (both rated Possibly Effective). The other stimulant ingredients—yohimbe, hordenine, N-methyltyramine, and picamilon—lack solid human research supporting their advertised effects.
Can I take this if I'm pregnant or breastfeeding?
No. Beta-alanine, creatine, yohimbe, and agmatine all advise against use during pregnancy, and yohimbe is considered unsafe. Caffeine should be limited in pregnancy and only in amounts your doctor approves. For breastfeeding, caffeine passes into milk in small amounts (usually acceptable with moderation), but other ingredients lack safety data. Talk to your doctor before using any of this product.
Why does this have three types of caffeine?
Caffeine Anhydrous is pure caffeine for quick energy. Caffeine Citrate is a bound form for different absorption. Infinergy is a patented slow-release caffeine. Using three sources together is meant to deliver both immediate and sustained energy, but it raises your total caffeine intake—and increases the risk of jitteriness, anxiety, and interactions with your medications.
Is there anything in this I can't check?
Yes. We could not check L-leucine, Rauwolfia vomitoria root extract, or the ingredient labeled 'Intensity Matrix' against our interaction data. If you take medications, mention those names to your pharmacist as well.
What are the most common side effects?
From caffeine: anxiety, insomnia, restlessness, tremors, nausea, and diarrhea. From beta-alanine: tingling and flushing. From yohimbe: anxiety, agitation, rapid heart rate, high blood pressure, and tremors. From creatine: water retention, muscle cramps, and gastrointestinal upset. From agmatine: diarrhea, nausea, and indigestion.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Mr Hyde Intense Energy Pre Workout Watermelon label
Go deeper

The Full Monographs Behind Mr Hyde Intense Energy Pre Workout Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Yohimbe

Interacts with 1,125 drugs

Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...

Read the full Yohimbe monograph → Herb & supplement monograph

Hordenine

Interacts with 329 drugs

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human evidence for these benefits is lacking. Its sa...

Read the full Hordenine monograph → Herb & supplement monograph

N-methyltyramine

Interacts with 344 drugs

N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added to weight-loss and pre-workout supplements. Solid h...

Read the full N-methyltyramine monograph → Herb & supplement monograph

Picamilon

Interacts with 3 drugs

Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supp...

Read the full Picamilon monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Mr Hyde Intense Energy Pre Workout Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 420 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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