Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Lion's Mane+ Ingredients & Drug Interactions

by Lifecykel

Lion's Mane+ label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane+ is a dietary supplement by Lifecykel with 3 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mycelium Extract, Kakadu Plum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane+ by Lifecykel

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane+ by Lifecykel — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane+ by Lifecykel

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,012 mg) without saying how much of each component you get.

Lion's Mane+ contains two active forms of lion's mane mushroom—the mycelium extract and the fruiting body extract—plus kakadu plum, a fruit rich in vitamin C. The product comes as a liquid and includes water and alcohol as inactive ingredients.

These 3 active ingredients are the working parts of the formula.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane mushroom on Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment is insufficient—the data we have doesn't support or rule out benefit for any of these uses. Kakadu plum is possibly effective for constipation, but the data for osteopenia, dyslipidemia (abnormal cholesterol or triglycerides), and hepatitis (liver inflammation) is also insufficient.

The evidence, ingredient by ingredient Lion's Mane Mushroom Plum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane mushroom is generally well tolerated as a food, but long-term supplement safety hasn't been well studied. The most common side effects are gastrointestinal discomfort, nausea, and skin rash.

Kakadu plum is generally well tolerated too, though it may cause flatulence and diarrhea; rarely, dried plums or plum pits have caused bowel obstruction. Since there isn't enough safety data in pregnancy or breastfeeding, both ingredients advise against use during those times—talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Lion's Mane Mushroom Plum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lion's Mane Mushroom, Plum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take blood thinners (anticoagulants or antiplatelet drugs) like warfarin or aspirin, diabetes medications, or immunosuppressants. These are the medication types with Moderate-severity interactions documented for this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Lion's Mane+ may be worth considering if you're interested in lion's mane or plum for general wellness, but talk with your pharmacist first if you take blood thinners, diabetes medications, or drugs that suppress your immune system. The evidence for its marketed purposes isn't solid yet.

Your healthcare provider can help you decide if it's appropriate for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane+, straight from the product label.

Brand Lifecykel
Barcode (UPC) 0793591581811
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320387
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane+ by Lifecykel, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
0793591581811
IngredientAmount% DV
Proprietary Blend1012 mg--
Lion's Mane Mycelium Extract0 NP--
Lion's Mane fruiting body extract0 NP--
Kakadu Plum0 NP--

Other ingredients: Water, Filtered, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Wild harvested kakadu plum natural flavor Full spectrum liquid extract

U.S. Grown Mushrooms

This product contains naturally occurring sulphur.

Formulation

Proudly Made in the USA

Vegan friendly

Non GMO Gluten free

General Statements

Find your flow

@LifeCykel Instagram Facebook Tiktok Youtube

FDA Statement of Identity

Dietary Supplement

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: Contains mushrooms. Do not use if sensitive to mushrooms.

Do not exceed recommended dose. If an excessive amount is accidentally swallowed or in the event of an adverse reaction, stop use and seek medical attention immediately.

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before use.

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before use.

Storage

Store in a cool, dark place or refrigerate.

Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement, take 2 ml per day. Avoid contact with eyes. Shake well before using.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane+ by Lifecykel label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane+ by Lifecykel

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1012 mg per serving

Other (inactive) ingredients: Water, Filtered, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane+ by Lifecykel Drug Interactions

Want to check YOUR meds against Lion's Mane+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mycelium Extract 327
Kakadu Plum 122

Individual Drug Interactions

The ingredients in Lion's Mane+ interact with 327 drugs. Click any drug to see the details.

2 of the 3 ingredients in Lion's Mane+ interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mycelium Extract Kakadu Plum

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mycelium Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mycelium Extract full monograph & interactions

Kakadu Plum1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, plum juice might have antiplatelet effects.
Consuming plum juice while taking anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. In healthy volunteers, drinking plum juice 200 mL daily for 28 days prolonged clotting time and inhibited platelet aggregation.

Likelihood Possible Evidence B
Kakadu Plum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane+, from the product label.

Lifecykel

See all Lifecykel products
Name
Lifecykel Labs, LLC.
Street Address
880 Frontage Rd.
City
Peshtigo
State
WI
ZipCode
54157
Web Address
lifecykel.com
Pharmacist Counseling Corner

Lion's Mane+ by Lifecykel: Common Questions

Does Lion's Mane+ by Lifecykel interact with any medications?
Yes. Based on its ingredients, Lion's Mane+ has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane+ contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Lion's Mane+ safe to take while I'm pregnant or breastfeeding?
The safety data for both lion's mane and kakadu plum in concentrated supplement form during pregnancy and breastfeeding isn't enough to know either way. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
What side effects might I have from this product?
Lion's mane may cause gastrointestinal discomfort, nausea, or skin rash. Kakadu plum may cause flatulence or diarrhea. Both ingredients are generally well tolerated, so side effects aren't common.
Does lion's mane actually help with memory or thinking?
The evidence for lion's mane on cognitive function, cognitive impairment, Alzheimer's disease, and anxiety is insufficient—we don't have reliable data to say whether it works for those purposes.
What is kakadu plum doing in this formula?
Kakadu plum is included as a source of vitamin C and is possibly effective for constipation. The evidence for its other uses like lowering cholesterol or helping the liver is insufficient.
Why does the label list alcohol as an ingredient?
Alcohol is used as a preservative and solvent in this liquid formulation. The amount is typical for liquid supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane+ is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane+ label
Go deeper

The Full Monographs Behind Lion's Mane+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Plum

Interacts with 122 drugs

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as f...

Read the full Plum monograph →
Sources

Sources & How We Checked

Lion's Mane+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Plum 10 references
  1. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
  2. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
  3. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
  4. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
  5. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed
  6. Jain M, Pielage P, De-Ryke R. Plum stones: an unusual cause of ileostomy obstruction demonstrated by sonography. J Clin Ultrasound. 1998;26(8):416-7. DOI
  7. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
  8. Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
  9. Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI
  10. Johnson MC, Fisher JK. Plum pit ileus: a case report. Mo Med. 1991;88(10):696-8.

See these in context on the Plum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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