Liquid Ashwagandha Ingredients & Drug Interactions
by plnt
What is this page for?
First and foremost: checking Liquid Ashwagandha against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liquid Ashwagandha is a dietary supplement by plnt with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ashwagandha. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liquid Ashwagandha by plnt
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liquid Ashwagandha by plnt
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: organic ashwagandha. The inactive ingredients are deionized water and organic grain alcohol, which serve as the liquid base and preservative.
Ashwagandha is an herb traditionally used to help with stress, anxiety, and sleep. In this liquid form, you're getting the plant extract in a convenient drop or drink format.
Does it work?
Moderate evidence
Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD), based on the evidence we hold. For bipolar disorder, the evidence isn't established enough to rate.
Keep in mind that "possibly effective" means there is some clinical support, but the research is still preliminary—it's not a guarantee it'll work the same way for you as it did in studies.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated in the short term in healthy adults, but long-term safety data are limited and quality varies across products. The most common side effects are mild—diarrhea, stomach upset, nausea, and vomiting—though these don't happen at typical doses.
Rare but serious concerns include liver damage (hepatitis and liver failure) and, in one case report, reversible cerebral vasoconstriction (a narrowing of blood vessels in the brain). Drowsiness has also been reported.
The safety data advises against ashwagandha in pregnancy because it's traditionally thought to increase the risk of miscarriage. There isn't enough information to know whether it's safe while breastfeeding, so avoidance is recommended until more is known.
Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this ashwagandha product, check with your doctor or pharmacist if you take any hepatotoxic drugs (liver-damaging medications), CNS depressants or benzodiazepines (sedatives, sleep aids, anti-anxiety drugs), antihypertensive drugs (blood pressure medications), antidiabetes drugs (blood sugar medications), thyroid hormone, immunosuppressants, or any CYP1A2 substrates. The largest concern is liver damage when combined with other hepatotoxic drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha may help with anxiety, stress, and sleep, and it's usually well tolerated at standard doses. However, it interacts with a very large number of medications—especially blood pressure drugs, diabetes medications, sedatives, thyroid hormone, and liver-damaging drugs—and it carries rare but serious risks including liver damage.
If you take any prescription medication, check it against this product with your doctor or pharmacist before starting. Avoid it if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liquid Ashwagandha, straight from the product label.
| Brand | plnt |
|---|---|
| Barcode (UPC) | 766536032570 |
| Net contents | 2 fl. Oz.; 59 mL |
| Market status | On market |
| Date entered into DSLD | May 28, 2019 |
| DSLD ID | 202159 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Organic, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liquid Ashwagandha by plnt, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Ashwagandha | 500 mg | -- |
Other ingredients: deionized Water, organic Grain Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Pure living, naturally true
Formula
Withania somnifera
K Parve K-1604
General Statements
Supports energy Supports vitality Stress management
This is a natural product. Color may vary.
Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.
FDA Statement of Identity
Liquid Dietary Supplement
Formulation
Gluten free Dairy free Soy free Nut free
Does not contain: Gluten, sugar, salt, artificial flavors or colors.
Certified Organic by the New Mexico Department of Agriculture
Seals/Symbols
USDA Organic
K Parve K-1604
Storage
Store in a cool, dry place.
Precautions
Keep out of reach of children.
Tamper evident Do not use if outer seal is broken or missing.
Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.
Suggested/Recommended/Usage/Directions
Directions: Take one (1) mL up to three (3) times daily, preferably with meals.
General
Item No. VS-3257 2169761 JS 28
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liquid Ashwagandha by plnt label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liquid Ashwagandha by plnt
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container59 Amounts shown are per serving.
Organic Ashwagandha
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Organic Ashwagandha monograph & interactionsOther (inactive) ingredients: Deionized Water, Organic Grain Alcohol. These complete the product’s ingredient list but are not active constituents.
Liquid Ashwagandha by plnt Drug Interactions
HelloPharmacist Interaction Report
Liquid Ashwagandha by plnt contains ashwagandha, which interacts with a large number of medications.
The most serious documented concern is with hepatotoxic drugs (medications that can damage the liver)—ashwagandha itself has been linked to cases of acute hepatitis, liver failure, and in rare cases, death from liver failure, and combining it with other liver-damaging drugs could increase that risk further.
Read the full breakdown — every affected drug type, severity by severity
Ashwagandha also has moderate interactions with CNS depressants (sedatives, barbiturates, and sleep aids), benzodiazepines (like Valium and Klonopin), antihypertensive drugs (blood pressure medications), antidiabetes drugs (blood sugar medications), thyroid hormone, and immunosuppressants. It may amplify sedation, lower blood pressure, increase low blood sugar risk, boost thyroid hormone effects, and potentially weaken immune-suppressing medications.
There is also a minor interaction with CYP1A2 substrates, a group of drugs your liver metabolizes.
Altogether, these interactions span 1,373 individual medications. Before you start this product, use the medication checker below to run through anything you're taking—especially blood pressure meds, diabetes medications, sedatives, benzodiazepines, thyroid hormone, immunosuppressants, and any drug known to stress your liver.
Your own doctor or pharmacist can tell you whether it's safe to combine.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liquid Ashwagandha?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liquid Ashwagandha interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Liquid Ashwagandha interact with drugs. Each result below shows which ingredient is responsible. organic Ashwagandha
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Abemaciclib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Acalabrutinib interactionAgomelatineValdoxan
How Agomelatine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha + Agomelatine interactionAlfuzosinUroxatral
How Alfuzosin interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Alfuzosin interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Alosetron interactionAlpelisibPiqray
How Alpelisib interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Alpelisib interactionAmoxapineAsendin
How Amoxapine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmprenavirAgenerase
How Amprenavir interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Amprenavir interactionAnagrelideAgrylin
How Anagrelide interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha + Anagrelide interactionApalutamideErleada
How Apalutamide interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Apixaban interactionApremilastOtezla
How Apremilast interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aprepitant interactionArmodafinilNuvigil
How Armodafinil interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Armodafinil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha + Asenapine interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha + Aspirin, Caffeine interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha + Aspirin, Caffeine, Orphenadrine interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha + Atogepant interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Liquid Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Organic AshwagandhaSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Organic Ashwagandha + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liquid Ashwagandha with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Ashwagandha
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Liquid Ashwagandha, from the product label.
plnt
See all plnt products- Name
- Vitamin Shoppe, Inc.
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-800-223-1216
- Web Address
- www.vitaminshoppe.com
Liquid Ashwagandha by plnt: Common Questions
Does Liquid Ashwagandha by plnt interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take ashwagandha if I'm on blood pressure medication?
Will this make me drowsy?
Is ashwagandha safe for my liver?
Can I take this if I have diabetes?
Is it safe to take ashwagandha long-term?
Can I take ashwagandha if I'm on thyroid medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Liquid Ashwagandha is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liquid Ashwagandha’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Liquid Ashwagandha's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
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