Liver Kidney Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Liver Kidney against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liver Kidney is a dietary supplement by Organic India with 3 active ingredients. Its ingredients are commonly taken for kidney stones, gallstones, liver support.Based on those ingredients, 1,113 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phyllanthus niruri, Picrorhiza kurroa. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liver Kidney by Organic India
Ask about any prescription or over-the-counter medication and we check it for interactions with Liver Kidney by Organic India — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liver Kidney by Organic India
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains three active herbal ingredients: Phyllanthus niruri (chanca piedra), Picrorhiza kurroa, and Boerhavia diffusa. The capsule itself is made from pullulan, an inactive ingredient used as a capsule material.
The three herbs are the working parts of this formula.
Does it work?
Moderate evidence
Phyllanthus niruri is rated possibly effective for kidney stones (nephrolithiasis) but likely ineffective for hepatitis B. It's also listed for anemia of chronic disease and benign prostatic hyperplasia (enlarged prostate), though evidence isn't established for those uses.
Picrorhiza is rated possibly effective for vitiligo, but possibly ineffective for asthma, with insufficient evidence for chronic obstructive pulmonary disease (COPD) and hepatitis. The evidence we hold doesn't support claims for the other conditions this product may be marketed toward.
How safe is it?
Well-documented data
Phyllanthus niruri is often well tolerated short-term, but high-quality long-term safety data are limited. It may cause abdominal pain, nausea, vomiting, or fatigue in some people.
The safety data advises against use during pregnancy and breastfeeding. Picrorhiza is used in traditional medicine but has limited human safety data — use with care.
It may cause vomiting, rash, loss of appetite, diarrhea, itching, or dizziness. The safety data also advises against use during pregnancy and breastfeeding.
We have no pregnancy or breastfeeding safety information on file for Boerhavia diffusa.
Meds to double-check
Moderate interaction found
Before taking Organic India Liver Kidney, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate concern), diabetes medications (Moderate), diuretics like furosemide or hydrochlorothiazide (Moderate), lithium (Moderate), immunosuppressants (Moderate), norepinephrine (Moderate), or blood pressure medications (Minor). The product may also affect how your liver processes certain medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is intended to support liver and kidney function, but evidence for most of those uses isn't established in our data. If you take blood thinners, diabetes medications, diuretics, immunosuppressants, or any blood pressure medication, or if you take lithium, talk it over with your doctor or pharmacist before starting — the herb chanca piedra may affect how these drugs work.
Pregnant or breastfeeding people should avoid this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liver Kidney, straight from the product label.
| Brand | Organic India |
|---|---|
| Barcode (UPC) | 850021635084 |
| Net contents | 180 Veg Cap(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 300188 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liver Kidney by Organic India, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Phyllanthus niruri | 250 mg | -- |
| Picrorhiza kurroa | 200 mg | -- |
| Boerhavia diffusa | 200 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
At the heart of Organic India is our commitment to be a living embodiment of love & consciousness in action. Whole herb solutions grown sustainably by small family farmers using regenerative organic agriculture. Healthy conscious living
Mfg. Lic. No. A-2755 Pictured: All three ingredients
Formulation
Liver Kidney supports both the liver and the kidneys as they work synergistically together as a powerful cleansing and detoxification team. Liver Kidney promotes healthy liver and kidney function, two essential organs that contribute significantly to overall good health and well being.
Vegan Vegetarian
Gluten free
Detoxify & rejuvenate
USDA Organic Certified Organic by Control Union-CU 801983 Product produced and processed according to NPOP standard of India & USDA-NOP NPOP/NAB/0010 www.controlunion.com
Non GMO Project Verified nongmoproject.org
Product of India For export to USA only
Suggested/Recommended/Usage/Directions
Suggested use: 2 capsules with food and water twice daily.
Precautions
Do not use if pregnant or nursing without consulting a physician.
Warning: Reproductive harm - www.P65Warnings.ca.gov
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Herbal Supplement
Formula
Halal Mumbai India
Seals/Symbols
USDA Organic Non GMO Project Verified nongmoproject.org Certified Organic by Control Union Certified B Corporation Halal Mumbai India OU (Kosher)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liver Kidney by Organic India label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liver Kidney by Organic India
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Phyllanthus niruri
Interacts with1,020 drugs
Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence f...
Phyllanthus niruri monograph & interactionsPicrorhiza kurroa
Interacts with207 drugs
Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small h...
Picrorhiza kurroa monograph & interactionsBoerhavia diffusa
Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Liver Kidney by Organic India Drug Interactions
HelloPharmacist Interaction Report
Organic India's Liver Kidney has interactions documented for two of its three active ingredients.
Through its Phyllanthus niruri (chanca piedra) and Picrorhiza kurroa content, this product may interact with a range of medications. The most serious documented concern is Moderate: chanca piedra may theoretically increase bleeding risk when combined with blood thinners and antiplatelet drugs (anticoagulants/antiplatelets).
Read the full breakdown — every affected drug type, severity by severity
Chanca piedra carries Moderate interactions with several other drug types: diuretics (water pills), lithium, norepinephrine (a blood pressure medication), drugs processed through liver pathways CYP1A2 and CYP3A4, and diabetes medications. It also carries a Minor interaction with blood pressure drugs.
Picrorhiza adds Moderate interactions with immunosuppressants and diabetes medications.
We could not check Boerhavia diffusa — no interaction data is on file for it. Altogether, these interactions span 1,114 individual medications.
Before starting this product, check your exact medications using the tool below.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liver Kidney?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liver Kidney interact with 1,113 drugs. Click any drug to see the details.
2 of the 3 ingredients in Liver Kidney interact with drugs. Each result below shows which ingredient is responsible. Phyllanthus niruri Picrorhiza kurroa
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Picrorhiza KurroaImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Picrorhiza Kurroa + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus Niruri + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
Phyllanthus NiruriAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus Niruri + Abrocitinib interactionPicrorhiza KurroaImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Picrorhiza Kurroa + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
Picrorhiza KurroaAntidiabetes Drugs Moderate
Interaction Summary
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels.
Read the full Picrorhiza Kurroa + Acarbose interactionPhyllanthus NiruriAntidiabetes Drugs Minor
Interaction Summary
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Read the full Phyllanthus Niruri + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus Niruri + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus Niruri + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Phyllanthus NiruriCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus Niruri + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liver Kidney with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Phyllanthus niruri
Anticoagulant/Antiplatelet Drugs
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.
Diuretic Drugs
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.
Lithium
Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.
Norepinephrine (Levophed)
Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.
Antidiabetes Drugs
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.
Antihypertensive Drugs
Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.
Picrorhiza kurroa
Antidiabetes Drugs
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels. Theoretically, picrorhiza might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Immunosuppressants
Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Brand information
Manufacturer and brand details for Liver Kidney, from the product label.
Organic India
See all Organic India products- Name
- Organic India USA
- City
- Boulder
- State
- CO
- ZipCode
- 80302
- Phone Number
- 1-888-550-8332
- Web Address
- organicindiaUSA.com
Liver Kidney by Organic India: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liver Kidney’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Chanca Piedra
Interacts with 1,020 drugsChanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...
Read the full Chanca Piedra monograph → Herb & supplement monographPicrorhiza
Interacts with 207 drugsPicrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-prot...
Read the full Picrorhiza monograph →Sources & How We Checked
Liver Kidney's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chanca Piedra 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
- Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
- Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
- Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
- Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
- Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
- Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
- Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
- Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
- Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
- Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
- Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
- Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
- Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
- Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
- Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
- Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed
Picrorhiza 7 references
- Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
- Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
- Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
- Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
- Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
- Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
- Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC