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Dietary supplement

Longjack Extract Ingredients & Drug Interactions

by BulkSupplements.com

Longjack Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Longjack Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Longjack Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Longjack Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Longjack Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Longjack Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Longjack Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Longjack Root Extract, a concentrated form of Eurycoma longifolia, a plant from Southeast Asia. There are no inactive ingredients listed in this formulation — it's just the extract itself in powder form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Eurycoma Longifolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Eurycoma Longifolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Natural Medicines).

The evidence for Longjack is mixed. It's rated possibly effective for sexual desire based on available studies.

For athletic performance, the data suggests it's possibly ineffective. The safety and effectiveness data for back pain, osteoporosis, and diabetes are too limited to rate — we simply don't have enough reliable evidence to say whether it works for those uses.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Longjack is generally well tolerated in short-term studies, but we don't have solid information on long-term safety or product quality consistency. There's a caution about testosterone: some research suggests it may increase testosterone levels, and if levels go beyond the normal range, there's potential for side effects like acne, insulin resistance, and liver concerns.

You should avoid this product during pregnancy due to insufficient safety data and possible hormonal effects. While breastfeeding, there's not enough reliable safety information, so it's best to skip it.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take propranolol (Inderal) or any blood pressure medication — Longjack can reduce its effectiveness. Also flag any medications that rely on your liver's CYP1A2, CYP2C19, or CYP2A6 enzyme systems, or if you're on testosterone therapy.

Your pharmacist can confirm whether any of your current drugs fall into these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Longjack may be worth considering if you're exploring options for sexual desire, but it's not a proven option for athletic performance or several other uses. The main concern is its interaction with propranolol and the theoretical effects on medications your liver processes.

If you take heart or blood pressure medications, hormonal drugs, or other prescriptions, check with your doctor or pharmacist before starting — the interaction profile here is worth a conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Longjack Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000IWOXOZ
Net contents 1 Kilogram(s); 35.3 Ounce(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 312196
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Longjack Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
80 mg
Maximum serving Sizes:
80 mg
Servings per container
12500
UPC/BARCODE
X000IWOXOZ
IngredientAmount% DV
Longjack Root Extract80 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formula

(Tongkat Ali)

Tongkat Ali for Men Eurycoma Longifolia for Men

Tongkat Ali for Men Eurycoma Longifolia for Men

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Color may vary

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 80 mg once daily or as directed by a physician.

Storage

Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

General Statements

Use an accurate milligram scale. Contents are sold by weight, not volume. Settling may occur. New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Longjack Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Longjack Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Longjack Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size80 mg Dosage formPowder Servings per container12500 Amounts shown are per serving.

Longjack Root Extract

Interacts with
248 drugs
80 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Longjack Root Extract monograph & interactions
Interaction report

Longjack Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Longjack Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Longjack Root Extract 248

Individual Drug Interactions

The ingredients in Longjack Extract interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Longjack Extract interact with drugs. Each result below shows which ingredient is responsible. Longjack Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Longjack Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Longjack Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Longjack Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Longjack Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Longjack Extract by BulkSupplements.com: Common Questions

Does Longjack Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Longjack Extract has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Longjack Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Longjack actually work for improving sexual desire?
The evidence says it's possibly effective — meaning there's some research support, but it's not definitive. Results vary, and more studies would help us understand it better. It's worth trying if you're curious, but talk with your doctor first if you have any underlying health concerns.
Can I take Longjack while I'm on propranolol for my heart?
No — at least not without talking to your doctor first. Studies show Longjack reduces propranolol levels by about 29%, which could make your heart medication less effective. Your doctor needs to know you're considering this before you start it.
What are the side effects if testosterone levels get too high?
If Longjack pushes your testosterone above the normal range, you could develop acne, insulin resistance, liver problems, and other testosterone-related effects. This is why it matters to know your baseline testosterone before taking it, especially if you're already on testosterone therapy.
Is Longjack safe during pregnancy or breastfeeding?
No to both. There's not enough safety data during pregnancy, and the possible hormonal effects make it risky, so avoid it. While breastfeeding, there's also not enough reliable information — it's best to wait until you're done.
How long can I safely take Longjack?
The safety data we have comes from short-term studies, so we don't know much about long-term safety or whether product quality stays consistent over time. Talk with your doctor about how long you plan to use it.
Does this powder have any fillers or added ingredients?
No — this product is just the Longjack Root Extract powder with no inactive ingredients listed. It's a straightforward single-ingredient formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Longjack Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Longjack Extract label
Go deeper

The Full Monographs Behind Longjack Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Longjack Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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