Lycium Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Lycium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lycium is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for general antioxidant support, eye health, immune support.Based on those ingredients, 1,000 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are dried Lycium fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lycium by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Lycium by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lycium by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dried Lycium fruit extract, commonly known as goji. The liquid also includes distilled water and ethyl alcohol as inactive ingredients.
Does it work?
Not established
The evidence supporting goji for sunburn, cardiovascular disease, high blood pressure, obesity, and quality of life is currently insufficient to rate. We don't have reliable data on file to confirm whether this product works for these uses.
How safe is it?
Well-documented data
Goji berries are generally well tolerated as a food, but concentrated supplements have less safety data behind them. A small number of case reports link goji to liver inflammation (hepatitis) and allergic reactions ranging from itching and facial swelling to severe swelling of the throat (angioedema) and anaphylaxis; it's unclear in some cases whether goji alone or other ingredients caused the harm.
The safety data advises against medicinal amounts during pregnancy due to limited information and traditional reports of effects on the uterus. There isn't enough reliable data to know whether this supplement is safe while breastfeeding; talk with your doctor or pharmacist for personalized guidance.
Meds to double-check
Major interaction found
Before taking this product, double-check with your doctor or pharmacist if you take warfarin or other blood thinners — goji raises bleeding risk. Also flag any medications that depend on liver enzymes (CYP2D6, CYP2C19, CYP2C9, or CYP3A4) to break down, blood pressure drugs, heart rhythm medications like flecainide, or diabetes medications, as goji may theoretically raise their levels or effects.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
If you take warfarin or any other prescription medication, you'll need to check this product with your doctor or pharmacist before starting — the interaction data is substantial and the warfarin risk is serious. Even if you're not on blood thinners, goji's effects on how your liver handles drugs warrant a conversation.
Pregnant people should avoid medicinal amounts. Use the interaction checker on this page with your complete medication list.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lycium, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056107550 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 174389 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lycium by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| dried Lycium fruit extract | 5 mL | -- |
Other ingredients: distilled Water, Ethyl Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Lycium barbarum
OK
General Statements
Supports healthy vision
Botanical preparation ratio 1:4
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: 60-100 drops (3-5 mL) in juice or water. Take 3 times per day. Shake well before using.
Precautions
Contraindications: Do not use if you have nightshade sensitivity or are allergic to peaches.
Contraindications: Do not use if you have nightshade sensitivity or are allergic to peaches.
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
General
NO. LMF-2 1736WE
Seals/Symbols
OK
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lycium by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lycium by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 mL Dosage formLiquid Servings per container12 Amounts shown are per serving.
Dried Lycium fruit extract
Interacts with1,000 drugs
Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they...
Dried Lycium fruit extract monograph & interactionsOther (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.
Lycium by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
Lycium by Herbalist & Alchemist, which contains dried goji fruit extract, does interact with medications.
The most serious concern is warfarin (Coumadin), a blood thinner — goji can increase warfarin's effects and raise bleeding risk. There are at least 5 case reports of patients on stable warfarin doses who experienced increased INR (a measure of blood thickness) after starting goji juice, tea, or wine.
Goji appears to slow how your body breaks down warfarin.
Read the full breakdown — every affected drug type, severity by severity
Beyond warfarin, goji may theoretically affect how your liver metabolizes several other drug types. In lab studies, goji inhibits multiple liver enzymes (CYP2D6, CYP2C19, CYP2C9, and CYP3A4), which could raise levels of medications that depend on these pathways — including some heart rhythm drugs, blood pressure medications, and diabetes drugs.
One case report links concentrated goji to flecainide (Tambocor) toxicity. However, most of these enzyme interactions haven't been confirmed in actual patients yet.
Blood pressure drugs theoretically could see additive effects, though goji fruit juice itself hasn't lowered blood pressure in human trials. Similarly, diabetes medications could theoretically have additive effects with goji's compounds, but this too hasn't been documented in people.
Altogether, these interactions span 1,001 individual medications. Use the interaction checker below with your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lycium?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lycium interact with 1,000 drugs. Click any drug to see the details.
1 of the 1 ingredient in Lycium interact with drugs. Each result below shows which ingredient is responsible. dried Lycium fruit extract
AlpelisibPiqray
How Alpelisib interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Dried Lycium Fruit Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
Read the full Dried Lycium Fruit Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
Read the full Dried Lycium Fruit Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Antihypertensive Drugs +1 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
Read the full Dried Lycium Fruit Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Ammonium Chloride interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
Read the full Dried Lycium Fruit Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Dried Lycium Fruit Extract + Amphetamine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Dried Lycium Fruit Extract + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmphetamine SulfateBenzedrine, Evekeo ODT
How Amphetamine Sulfate interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Dried Lycium Fruit Extract + Amphetamine Sulfate interactionAmprenavirAgenerase
How Amprenavir interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Amprenavir interactionApalutamideErleada
How Apalutamide interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Apixaban interactionApremilastOtezla
How Apremilast interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Aprepitant interactionAprocitentanTryvio
How Aprocitentan interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Dried Lycium Fruit Extract + Aprocitentan interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Dried Lycium Fruit Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Lycium — through 1 ingredient. Tap an ingredient for the detail:
Dried Lycium Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Dried Lycium Fruit Extract + Armodafinil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lycium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
dried Lycium fruit extract
Warfarin (Coumadin)
Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).
Antihypertensive Drugs
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.
Flecainide (Tambocor)
Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.
Antidiabetes Drugs
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.
Brand information
Manufacturer and brand details for Lycium, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Lycium by Herbalist & Alchemist: Common Questions
Does Lycium by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant?
Is goji safe to take while breastfeeding?
What are the side effects?
Does goji actually work for high blood pressure or heart health?
Why does this liquid contain alcohol?
Can I take this with my blood pressure medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lycium is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lycium’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lycium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Goji 14 references
- Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
- Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
- Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
- Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
- Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
- Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
- Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
- Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
- Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
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