Manganese Picolinate Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Manganese Picolinate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Manganese Picolinate is a dietary supplement by Thorne Research with 1 active ingredient. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Manganese Picolinate by Thorne Research
Ask about any prescription or over-the-counter medication and we check it for interactions with Manganese Picolinate by Thorne Research — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Manganese Picolinate by Thorne Research
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Manganese.
- The most serious interaction on file is rated Moderate.
- For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Manganese Picolinate, straight from the product label.
| Brand | Thorne Research |
|---|---|
| Barcode (UPC) | 693749211020 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Nov 21, 2012 |
| DSLD ID | 15771 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Manganese Picolinate by Thorne Research, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Manganese | 15 mg | 750% |
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from Cellulose) Capsule, Leucine, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
DIETARY SUPPLEMENT
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Precautions
Tamper Evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Storage
Store tightly sealed in a cool, dry place.
Seals/Symbols
(pulled apart capsule)(R)
Formula
HYPOALLERGENIC
General
M211 LM21106
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Manganese Picolinate by Thorne Research label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Manganese Picolinate by Thorne Research
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Manganese
Interacts with83 drugs
Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...
Manganese monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Hypromellose (derived from Cellulose) Capsule, Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Manganese Picolinate by Thorne Research Drug Interactions
Manganese Picolinate contains a single active ingredient, and it has known interactions with 83 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Manganese Picolinate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Manganese Picolinate interact with 83 drugs. Click any drug to see the details.
1 of the 1 ingredient in Manganese Picolinate interact with drugs. Each result below shows which ingredient is responsible. Manganese
AcepromazineAtravet
How Acepromazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Acepromazine interactionAcetophenazineTindal
How Acetophenazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Acetophenazine interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Amitriptyline, Perphenazine interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Amphotericin, Tetracycline interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Aripiprazole Lauroxil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Asenapine interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Brexpiprazole interactionButaperazineRepoise
How Butaperazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Butaperazine interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Cariprazine Hydrochloride interactionCarphenazineProketazin
How Carphenazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Carphenazine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Chlorpromazine interactionChlorprothixeneTaractan
How Chlorprothixene interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Chlorprothixene interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseQuinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Read the full Manganese + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseQuinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Read the full Manganese + Ciprofloxacin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseQuinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Read the full Manganese + Clinafloxacin interactionClozapineClozaril, Versacloz
How Clozapine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Clozapine interactionCyamemazineTercian
How Cyamemazine interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Cyamemazine interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Demeclocycline interactionDoripenemDoribax
How Doripenem interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics, Quinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Doxycyline interactionEnoxacinPenetrex
How Enoxacin interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseQuinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Read the full Manganese + Enoxacin interactionEravacyclineXerava
How Eravacycline interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Read the full Manganese + Eravacycline interactionFinafloxacinXtoro
How Finafloxacin interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseQuinolone Antibiotics Moderate
Interaction Summary
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Read the full Manganese + Finafloxacin interactionFlupenthixolFluanxol
How Flupenthixol interacts with Manganese Picolinate — through 1 ingredient. Tap an ingredient for the detail:
ManganeseAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Read the full Manganese + Flupenthixol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Manganese Picolinate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Manganese
Antipsychotic Drugs
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.
Quinolone Antibiotics
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.
Tetracycline Antibiotics
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.
Brand information
Manufacturer and brand details for Manganese Picolinate, from the product label.
Thorne Research
See all Thorne Research products- Name
- Thorne Research, Inc.
- Street Address
- P.O. Box 25
- City
- Dover
- State
- Idaho
- ZipCode
- 83825
- Phone Number
- 1-800-228-1966
- Web Address
- www.thorne.com
Manganese Picolinate by Thorne Research: Common Questions
Does Manganese Picolinate by Thorne Research interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Manganese Picolinate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Manganese Picolinate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Manganese Picolinate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Manganese 21 references
- Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
- Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
- Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
- Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
- McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
- Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
- Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
- Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
- Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
- Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
- Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
- Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
- Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
- Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
- Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
- Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
- Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
- Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
- Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC