Major interaction on record — check this product against your medications before combining. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

Matrix Amino Tangy Mango Ingredients & Drug Interactions

by Syntrax

Matrix Amino Tangy Mango label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Matrix Amino Tangy Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Matrix Amino Tangy Mango is a dietary supplement by Syntrax with 9 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 302 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, L-Citrulline, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Matrix Amino Tangy Mango by Syntrax

Ask about any prescription or over-the-counter medication and we check it for interactions with Matrix Amino Tangy Mango by Syntrax — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Matrix Amino Tangy Mango by Syntrax

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Matrix Amino by Syntrax contains nine active ingredients—three branched-chain amino acids (L-leucine, L-isoleucine, and L-valine), plus L-citrulline, beta-alanine, HICA, and both sodium and calcium as mineral components. These amino acids are building blocks your muscles use during and after exercise.

The powder also contains inactive ingredients including citric acid, natural flavors, silicon dioxide, sunflower lecithin, gardenia fruit juice powder, acesulfame-K, and sucralose for taste and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle support and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Exercise-induced muscle damage, Muscle strength, Physical performance, muscle recovery — and 2 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Evidence for this product's ingredients is mixed. Beta-alanine is possibly effective for athletic and physical performance.

L-citrulline is possibly effective for athletic performance but possibly ineffective for sarcopenia (age-related muscle loss). Calcium is effective for bone health (osteoporosis) and several other conditions.

For other claimed uses—heart health, cognitive function, and disease prevention—the evidence we hold is insufficient to rate or doesn't support the claim. Talk with your own doctor or pharmacist about whether this product matches your fitness or health goals.

The evidence, ingredient by ingredient Sodium Calcium L-citrulline Beta-alanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium and calcium are generally well tolerated at normal dietary amounts, but this product contains both as supplements. High sodium intake is linked to high blood pressure and heart strain; the safety notes advise against supplemental sodium without medical advice.

Calcium at recommended doses is generally safe, though high doses raise theoretical concerns about kidney stones and cardiovascular risk. Beta-alanine commonly causes a harmless tingling sensation (paresthesia) and flushing, especially on the scalp, within minutes of a dose.

L-citrulline may cause gastrointestinal discomfort or heartburn in some people.

Side effects, ingredient by ingredient Sodium Calcium L-citrulline Beta-alanine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Calcium, L-citrulline, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 302 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use HIV integrase inhibitors (dolutegravir, elvitegravir—Major risk), intravenous ceftriaxone (Major risk), blood pressure medications, lithium, corticosteroids, thyroid medication (levothyroxine), heart rhythm or heart failure drugs (sotalol, diltiazem), psoriasis treatments (calcipotriene), or erectile dysfunction drugs. The sodium and calcium in this powder can significantly change how these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This amino acid powder is designed for athletes wanting branched-chain amino acid and beta-alanine support. If you take blood pressure medications, HIV drugs, lithium, corticosteroids, or any other prescription, check your exact medications with the tool on this page before starting—the sodium and calcium content can interact with many common drugs.

Pregnant or breastfeeding individuals should talk with their doctor or pharmacist first, especially regarding sodium citrate. Run this by your own healthcare provider to make sure it fits your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Matrix Amino Tangy Mango, straight from the product label.

Brand Syntrax
Barcode (UPC) 893912125547
Net contents 13.1 Ounce(s); 370 Gram(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228572
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Matrix Amino Tangy Mango by Syntrax, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
30
UPC/BARCODE
893912125547
IngredientAmount% DV
Calories40 Calorie(s)--
Sodium230 mg10%
Calcium60 mg4%
L-Leucine5000 mg--
L-Isoleucine500 mg--
L-Citrulline2000 mg--
L-Valine500 mg--
Beta-Alanine1600 mg--
Sodium Citrate1000 mg--
HICA500 mg--

Other ingredients: Citric Acid, Natural flavors, Silicon Dioxide, Sunflower Lecithin, Gardenia fruit juice powder, Acesulfame-K, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Matrix Amino is the most comprehensive and effective amino acid supplement available to athletes.

Matrix Amino is the most comprehensive and effective amino acid supplement available to athletes. No other formula contains the high quantities and precise ratios of muscle-supporting amino acids, such as leucine, valine, isoleucine and HICA (the leucine metabolite that is 4 times as strong as leucine at only 1/4 the dosage). Matrix Amino also contains a powerful dose of citrulline and beta-alanine to maintain optimal blood flow, muscle pump and muscular endurance during intense exercise. Finally, a healthy dose of hydration-promoting electrolytes are included to help athletes power through every workout. Since all flavors contain only natural and healthy food colors, you never have to worry about the ill-effects of synthetic chemicals created in a lab. Each and every flavor of Matrix Amino is a culinary work of art that is designed to make you say, "WOW"!

BCAA amino blend Optimal amounts of BCAAs, L-Citrulline, B-Alanine and HICA

Formulation

Unlike other amino acid formulas that are bitter and extremely unappetizing, Matrix Amino tastes nearly identical to pure, refreshing fruit juice...but without the sugar.

Made in the USA

No artificial colors

No bitter taste Replenishes critical electrolytes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

facebook.com/OfficialSyntrax instagram.com/OfficialSyntrax

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendations: Based on taste preference, mix 8-12 oz of water per scoop of Matrix Amino. May be consumed one to three times per day depending on desired results. Remember, Matrix Amino may be consumed throughout the day but is especially effective before, during and after exercise.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Matrix Amino Tangy Mango by Syntrax label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Matrix Amino Tangy Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Matrix Amino Tangy Mango by Syntrax

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size12 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
230 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
60 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

L-Leucine

5000 mg per serving

L-Isoleucine

500 mg per serving

L-Citrulline

Interacts with
178 drugs
2000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

L-Valine

500 mg per serving

Beta-Alanine

No known
interactions
1600 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

Sodium Citrate

Interacts with
205 drugs
1000 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium Citrate monograph & interactions

HICA

500 mg per serving Form: Calcium Salt

Other (inactive) ingredients: Citric Acid, Natural flavors, Silicon Dioxide, Sunflower Lecithin, Gardenia fruit juice powder, Acesulfame-K, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Matrix Amino Tangy Mango by Syntrax Drug Interactions

Want to check YOUR meds against Matrix Amino Tangy Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
302Drugs
7 Major 293 Moderate 2 Minor

Ingredients driving the most interactions

Sodium 205
L-Citrulline 178
Calcium 168

Individual Drug Interactions

The ingredients in Matrix Amino Tangy Mango interact with 302 drugs. Click any drug to see the details.

3 of the 9 ingredients in Matrix Amino Tangy Mango interact with drugs. Each result below shows which ingredient is responsible. Sodium L-Citrulline Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Matrix Amino Tangy Mango with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Matrix Amino Tangy Mango, from the product label.

Syntrax

See all Syntrax products
Name
SI03, Inc.
Street Address
PO Box 1715
City
Cape Girardeau
State
MO
ZipCode
63702
Phone Number
(866) 333-7403
Web Address
www.syntrax.com
Pharmacist Counseling Corner

Matrix Amino Tangy Mango by Syntrax: Common Questions

Does Matrix Amino Tangy Mango by Syntrax interact with any medications?
Yes. Based on its ingredients, Matrix Amino Tangy Mango has a known interaction with 302 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Matrix Amino Tangy Mango contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my muscle growth or athletic performance?
Beta-alanine in the product is possibly effective for athletic and physical performance. L-citrulline is also possibly effective for athletic performance. The branched-chain amino acids (leucine, isoleucine, valine) are standard muscle-building ingredients, though our data doesn't rate their effectiveness here. Results vary by person and training routine—talk with your doctor or trainer about whether this fits your goals.
What's that tingling feeling I might get from this powder?
That's beta-alanine causing paresthesia—a harmless, temporary pins-and-needles sensation, usually on the scalp and spreading to the body, lasting roughly an hour. It's dose-dependent and mild at lower amounts. It's not dangerous, just uncomfortable for some people.
Can I take this while pregnant or breastfeeding?
The safety data for L-citrulline, beta-alanine, and L-valine in pregnancy and breastfeeding is insufficient—there isn't enough information to know either way. Sodium citrate is rated possibly unsafe in lactation. Talk with your doctor or pharmacist for personalized advice before using this product during pregnancy or while breastfeeding.
Does this have any fillers or other junk?
It contains several inactive ingredients: citric acid, natural flavors, silicon dioxide, sunflower lecithin, gardenia fruit juice powder, acesulfame-K, and sucralose. These are standard excipients for taste, texture, and stability in powders.
How much sodium is in a serving, and is that a problem?
The product facts don't specify the sodium amount per serving. Because sodium can interact with blood pressure drugs, lithium, and corticosteroids, you'll want to check the label and talk with your pharmacist about whether the total fits your diet and medications.
What if I'm on thyroid medication—is this safe?
This product contains calcium, which can reduce how well thyroid medication (levothyroxine) is absorbed. If you take it, separate your doses by at least 4 hours. Check with your doctor or pharmacist to plan the best timing for both.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Matrix Amino Tangy Mango label
Go deeper

The Full Monographs Behind Matrix Amino Tangy Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph →
Sources

Sources & How We Checked

Matrix Amino Tangy Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
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See these in context on the Sodium monograph →

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L-citrulline 8 references
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See these in context on the L-citrulline monograph →

Beta-alanine 13 references
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See these in context on the Beta-alanine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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