Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Moodbiotic Ingredients & Drug Interactions

by NS Natural Stacks

Moodbiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Moodbiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Moodbiotic is a dietary supplement by NS Natural Stacks with 4 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum R0175, Lactobacillus Helveticus R0052. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Moodbiotic by NS Natural Stacks

Ask about any prescription or over-the-counter medication and we check it for interactions with Moodbiotic by NS Natural Stacks — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Moodbiotic by NS Natural Stacks

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Probiotic Cultures” is listed as a grouped ingredient — the label gives one combined amount (46 mg) without saying how much of each component you get.

Moodbiotic contains four probiotic ingredients — two named strains (Bifidobacterium longum R0175 and Lactobacillus helveticus R0052), a probiotic culture blend, and two additional Lactobacillus strains (plantarum and brevis). These are live beneficial bacteria meant to support your gut microbiome.

The capsule also includes inactive ingredients: microcrystalline cellulose, cellulose, ascorbyl palmitate (a form of vitamin C), and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Mood and stress support via gut-brain axis.
  • We looked for evidence on: Depression, Generalized anxiety disorder (GAD), Irritable bowel syndrome (IBS), Stress, Anxiety, Emotional wellness.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Depression, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Depression, Irritable bowel syndrome (IBS).

The evidence for what these probiotic strains can do is not established in our data. For Bifidobacterium longum, we have insufficient reliable evidence to rate it for age-related cognitive decline, hay fever, antibiotic-associated diarrhea, anxiety, asthma, or athletic performance.

Similarly, Lactobacillus helveticus has insufficient evidence for hay fever, antibiotic-associated diarrhea, cognitive function, depression, rotaviral diarrhea, and exercise-related respiratory infections. We could not assess the effectiveness of Lactobacillus plantarum SD-5870 or Lactobacillus brevis CGMCC 21249 from our available data.

The evidence, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The two strains we have data on — Bifidobacterium longum and Lactobacillus helveticus — are generally well tolerated in healthy people. However, caution is advised if you're seriously ill or have a weakened immune system, as rare cases of bacterial infection (bacteremia or sepsis) have been reported in critically ill infants and adults, particularly after antibiotic use or major surgery.

Oral side effects have been rare and mild: abdominal discomfort, bloating, flatulence, constipation, and in one case, a dry cough. For pregnancy and breastfeeding, Bifidobacterium longum is rated possibly safe; data for Lactobacillus helveticus during pregnancy or breastfeeding are not on file.

Talk with your doctor or pharmacist before using if you are pregnant or breastfeeding.

Side effects, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Longum, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic medications before starting Moodbiotic. Antibiotics can significantly reduce how well these probiotic strains work by killing the live organisms in the product.

Your doctor or pharmacist can help you time doses appropriately — usually by spacing them several hours apart.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Moodbiotic is a four-strain probiotic blend with limited established evidence for any specific benefit in our data. If you take antibiotics, you'll want to space them apart from this product and check with your doctor or pharmacist about the best timing.

If you're seriously ill, immunocompromised, or pregnant or breastfeeding, discuss this product with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Moodbiotic, straight from the product label.

Brand NS Natural Stacks
Barcode (UPC) 718879621614
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274267
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Moodbiotic by NS Natural Stacks, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
718879621614
IngredientAmount% DV
Bifidobacterium longum R01756 mg--
Lactobacillus Helveticus R005218 mg--
Total Probiotic Cultures46 mg--
Lactobacillus plantarum SD-587017 mg--
Lactobacillus brevis CGMCC 212495 mg--

Other ingredients: Microcrystalline Cellulose, Cellulose, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule per day, or as directed by a healthcare practitioner.

General Statements

Certified Open Source: Scan for ingredient supplier information and 3rd party lab test results.

Storage

Refrigeration not required. Store in a cool, dry place, away from light.

Precautions

Warning: Consult a healthcare practitioner before taking this or any nutritional supplement if you are pregnant/nursing, have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.

Do not use if safety seal is broken or missing.

Keep out of reach of children.

Contains milk and soy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Certified Open Source Full Label Disclosure USA manufactured in a cGMP certified facility.

Formulation

Better mood & less stress

3rd party lab tested

Formula

Brain probiotics CEREBIOME

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

CEREBIOME is a registered trademark of Lallemand.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Moodbiotic by NS Natural Stacks label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Moodbiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Moodbiotic by NS Natural Stacks

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Probiotic Cultures

46 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Moodbiotic by NS Natural Stacks Drug Interactions

Want to check YOUR meds against Moodbiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum R0175 182
Lactobacillus Helveticus R0052 182

Individual Drug Interactions

The ingredients in Moodbiotic interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in Moodbiotic interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum R0175 Lactobacillus Helveticus R0052

Each ingredient & the kinds of drugs it affects

For each ingredient in Moodbiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum R01751 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum R0175 full monograph & interactions

Lactobacillus Helveticus R00521 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus Helveticus R0052 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Moodbiotic, from the product label.

NS Natural Stacks

See all NS Natural Stacks products
Name
NS 360, Inc.
Street Address
4241 24th Ave W
City
Seattle
State
WA
ZipCode
98199
Phone Number
1-855-678-2257
Web Address
www.naturalstacks.com
Pharmacist Counseling Corner

Moodbiotic by NS Natural Stacks: Common Questions

Does Moodbiotic by NS Natural Stacks interact with any medications?
Yes. Based on its ingredients, Moodbiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Moodbiotic contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Moodbiotic while I'm on antibiotics?
You can, but you'll need to separate when you take them. Antibiotics can kill the live bacteria in Moodbiotic and make it less effective. Talk with your doctor or pharmacist about how many hours apart to space them — they can recommend a schedule that works for your specific antibiotic and dosing.
Is this safe if I have a weak immune system?
Caution is needed. While these probiotics are generally well tolerated in healthy people, serious illness or a weakened immune system increases the risk of rare bacterial infections. Talk with your doctor before using Moodbiotic if you're immunocompromised or critically ill.
Can I take this while breastfeeding?
We have limited safety data. Bifidobacterium longum is rated possibly safe during breastfeeding, but data for the other strains aren't on file. Check with your doctor or pharmacist before starting — they can weigh the potential benefits against what we don't yet know.
What does this probiotic actually do?
Our data show insufficient reliable evidence to confirm what these strains can do for conditions like anxiety, cognitive decline, hay fever, or diarrhea. That doesn't mean they don't work — just that the evidence we hold isn't established yet. Talk with your doctor about whether it might be right for you.
Are there any common side effects?
Side effects are rare when taken orally. A small number of people have reported mild abdominal discomfort, bloating, flatulence, or constipation. One person reported a dry cough. These usually pass quickly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Moodbiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Moodbiotic label
Go deeper

The Full Monographs Behind Moodbiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Moodbiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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