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Dietary supplement

Mucuna 4:1 Extract Powder Ingredients & Drug Interactions

by TerraVita Premium Collection

Mucuna 4:1 Extract Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mucuna 4:1 Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mucuna 4:1 Extract Powder is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Mucuna Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mucuna 4:1 Extract Powder by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Mucuna 4:1 Extract Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mucuna 4:1 Extract Powder by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: Mucuna Extract, a concentrated form of cowhage (also called cowitch). Cowhage naturally contains levodopa, a compound your body converts to dopamine.

The extract is in powder form with no inactive fillers listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cowhage product and its label doesn't state a use — see Cowhage's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for what this product does isn't established in our data. The supplement has been studied for anxiety, erythema (skin redness), high prolactin levels, muscle pain, Parkinson's disease, and rheumatoid arthritis, but the current evidence for each of these is insufficient to rate whether it works.

The evidence, ingredient by ingredient Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adverse effects are uncommon, though some people report diarrhea, flatulence, mucosal irritation, dry mouth, headaches, or nausea—and in clinical trials, insomnia appeared in about 3% of patients taking higher doses. Because this powder contains levodopa, a drug-like compound, it needs to be used carefully under professional guidance.

The safety data advises against use during pregnancy and while breastfeeding: levodopa can lower prolactin and reduce milk supply, and there's not enough safety information for pregnancy.

Side effects, ingredient by ingredient Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take MAOIs (especially non-selective ones), methyldopa, levodopa, antidiabetes drugs, antipsychotics, tricyclic antidepressants, certain anesthetics, or guanethidine. The most serious risks are hypertensive crisis and dangerously low blood pressure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a potent supplement—not a food or a mild herb. If you're on blood pressure medication, antidepressants, diabetes drugs, antipsychotics, or MAOIs, you need to check with your pharmacist before trying it.

Pregnant or breastfeeding? Talk to your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mucuna 4:1 Extract Powder, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435208431
Net contents 1 Ounce(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 290801
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mucuna 4:1 Extract Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
28
UPC/BARCODE
064435208431
IngredientAmount% DV
Mucuna Extract, Powder1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mucuna 4:1 Extract Powder by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mucuna 4:1 Extract Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mucuna 4:1 Extract Powder by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Mucuna Extract, Powder

Interacts with
193 drugs
1000 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna Extract, Powder monograph & interactions
Interaction report

Mucuna 4:1 Extract Powder by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Mucuna 4:1 Extract Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

Mucuna Extract, Powder 193

Individual Drug Interactions

The ingredients in Mucuna 4:1 Extract Powder interact with 193 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mucuna 4:1 Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Mucuna Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Mucuna 4:1 Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mucuna Extract, Powder8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mucuna 4:1 Extract Powder, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Mucuna 4:1 Extract Powder by TerraVita Premium Collection: Common Questions

Does Mucuna 4:1 Extract Powder by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Mucuna 4:1 Extract Powder has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mucuna 4:1 Extract Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against both. During pregnancy, there isn't enough information about its dopamine effects. While breastfeeding, the levodopa in it can lower prolactin and reduce milk supply. Talk to your doctor before considering it.
What are the most common side effects?
Diarrhea, flatulence, and mucosal irritation happen orally. Some people also report dry mouth, headaches, or nausea. In clinical trials, insomnia showed up in about 3% of patients taking larger doses.
Why does this product interact with so many medications?
Because it contains levodopa, an active drug-like compound. Levodopa affects dopamine and blood pressure, so it clashes with blood pressure drugs, antipsychotics, antidepressants, and others that work on similar pathways.
Is this safe to use on my skin?
The safety data we have is for oral use only. Topically, cowhage bean pod or seed may be unsafe and can cause redness, itching, or rash—so don't use it that way.
How much levodopa is in each dose?
We don't have the specific amount for this product. Cowhage extracts vary widely—they can contain 75–400 mg of levodopa per dose. Ask the manufacturer or your pharmacist for the exact amount in your batch.
Can this help with Parkinson's disease?
Cowhage has been studied for Parkinson's disease, but the current evidence is not strong enough to rate whether it works. If you have Parkinson's, talk to your neurologist before adding this—especially because it interacts with levodopa medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mucuna 4:1 Extract Powder label
Go deeper

The Full Monographs Behind Mucuna 4:1 Extract Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Mucuna 4:1 Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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