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Dietary supplement

Nanoflora Ingredients & Drug Interactions

by BioPharma Scientific

Nanoflora label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nanoflora against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nanoflora is a dietary supplement by BioPharma Scientific with 1 active ingredient. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis DE111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nanoflora by BioPharma Scientific

Ask about any prescription or over-the-counter medication and we check it for interactions with Nanoflora by BioPharma Scientific — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nanoflora by BioPharma Scientific

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Nanoflora contains one active ingredient: Bacillus subtilis DE111, a probiotic bacterium meant to support gut health. The capsule itself is made from vegetable material, and rice maltodextrin is included as an inactive ingredient to help preserve and stabilize the live organisms inside.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bacillus Subtilis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Urinary tract health.
  • We looked for evidence on: Urinary tract infection (UTI), Bladder health, Uropathogens.
  • The closest evidence on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Clostridioides difficile infection (Natural Medicines).

The evidence on Bacillus subtilis is mixed. It's rated possibly effective for antibiotic-associated diarrhea—that's the one use where there's enough data to suggest a real benefit.

For athletic performance, constipation, eczema, cirrhosis, and diabetes, the evidence isn't established yet in the data we hold. If you're considering this for any of those other conditions, talk it over with your doctor.

The evidence, ingredient by ingredient Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus subtilis DE111 is generally well tolerated in healthy adults, though product quality and safety can vary between brands and strains. In clinical trials, only a handful of side effects were reported: one case of headache and rare cases of diarrhea.

There's a cautionary note in the medical literature about Bacillus subtilis var. natto (a different strain) and serious infections like bloodstream or brain infection in people who are immunocompromised—this was linked to very frequent consumption of natto (fermented soybeans). Safety data for this specific product is limited, so check with your doctor before you start, especially if you have a weakened immune system.

Side effects, ingredient by ingredient Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The big one is antibiotic drugs. Because this product contains live bacteria, taking antibiotics at the same time can kill the probiotic and make it less effective—so separate them by several hours or as your doctor advises.

If you take antibiotics regularly or are about to start a course, confirm the timing with your pharmacist before you begin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nanoflora may help if you're dealing with antibiotic-associated diarrhea, though evidence for other uses isn't established yet. The main caution is timing it away from antibiotics—they'll interfere with each other.

If you take any antibiotics or have a weakened immune system, talk with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nanoflora, straight from the product label.

Brand BioPharma Scientific
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270758
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nanoflora by BioPharma Scientific, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Bacillus subtilis DE1110 NP--

Other ingredients: Rice Maltodextrin, Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Probiotic UTI health Nanoflora supports: Urinary tract health

What makes nanoflora different: - Premium quality sourcing - Non-dairy source - Stable - Clinically studied

What makes nanoflora different: - Premium quality sourcing - Non-dairy source - Stable - Clinically studied

FDA Statement of Identity

Dietary Supplement

Formula

Nanoflora contains DE111. DE111 is Deerland Enzymes' single strain of the probiotic spore, Bacillus Subtilis. DE111 controls microbial populations in the gut by crowding out the bad bacteria such as E. Coli, making room for growth of good bacteria. DE111 can bind to the epithelial cells of the intestinal lining and increase numbers; this promotes a stronger intestinal lining to protect against immune response to food molecules that may be interpreted by the body as foreign objects.

DE111 Probiotic

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule per day after a meal or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to using this product if you are pregnant, nursing, taking prescription medications or prior to any surgical procedures.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nanoflora by BioPharma Scientific label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nanoflora label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nanoflora by BioPharma Scientific

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Bacillus subtilis DE111

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis DE111 monograph & interactions

Other (inactive) ingredients: Rice Maltodextrin, Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nanoflora by BioPharma Scientific Drug Interactions

Want to check YOUR meds against Nanoflora?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis DE111 182

Individual Drug Interactions

The ingredients in Nanoflora interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nanoflora interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis DE111

Each ingredient & the kinds of drugs it affects

For each ingredient in Nanoflora with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis DE111 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nanoflora, from the product label.

BioPharma Scientific

Name
Biopharma Scientific
Pharmacist Counseling Corner

Nanoflora by BioPharma Scientific: Common Questions

Does Nanoflora by BioPharma Scientific interact with any medications?
Yes. Based on its ingredients, Nanoflora has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nanoflora contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Nanoflora at the same time as my antibiotic?
No—you'll want to space them apart. Antibiotics can kill the live bacteria in this product, which defeats the purpose. Your pharmacist can help you figure out the best timing, usually giving the antibiotic first and starting Nanoflora after the course is done.
What is Bacillus subtilis DE111?
It's a probiotic strain—a type of beneficial bacterium meant to support your gut health. This particular strain, DE111, is the active ingredient in Nanoflora.
Does Nanoflora work for diarrhea?
The evidence suggests it may help if your diarrhea was caused by antibiotics. For other types of diarrhea or other conditions, the evidence isn't established yet.
What side effects have been reported?
Side effects are rare. One trial participant reported a headache, and diarrhea has been reported rarely. Most people tolerate it well, though quality and safety can vary between brands.
Is there enough safety data on Nanoflora for pregnancy or breastfeeding?
Safety data for pregnancy and lactation isn't on file for this product. If you're pregnant or breastfeeding, talk with your doctor before taking it to see if it's right for you.
Can I take this if my immune system is weak?
Check with your doctor first. While this strain is generally well tolerated, there are rare reports of serious infections in people who are immunocompromised, so personalized medical advice matters here.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nanoflora is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nanoflora label
Go deeper

The Full Monographs Behind Nanoflora’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Nanoflora's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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