Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Natural Mucuna Pruriens 1000 mg Ingredients & Drug Interactions

by NusaPure

Natural Mucuna Pruriens 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Mucuna Pruriens 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Natural Mucuna Pruriens 1000 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Mucuna pruriens Seed Extract, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Natural Mucuna Pruriens 1000 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Mucuna Pruriens 1000 mg by NusaPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Natural Mucuna Pruriens 1000 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mucuna pruriens seed extract, a natural botanical that supplies levodopa (also called L-dopa)—an amino acid your body uses to make dopamine, a key brain chemical. The dose is 1000 mg per capsule.

The inactive ingredients are cellulose, magnesium stearate, silica, and rice powder—standard capsule fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cowhage product and its label doesn't state a use — see Cowhage's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on mucuna pruriens for anxiety, skin inflammation (erythema), high prolactin levels, muscle pain, Parkinson's disease, and rheumatoid arthritis all rates as insufficient—meaning there isn't enough reliable research yet to say whether it works for any of these uses. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mucuna pruriens contains levodopa, which is a powerful compound and needs to be used carefully with professional guidance. Adverse effects from taking it by mouth appear to be uncommon overall, but some people report diarrhea, gas, dry mouth, nausea, stomach bloating, vomiting, or headaches.

In clinical trials, about 3% of people taking higher doses reported insomnia. The safety data advises against using this product during pregnancy due to insufficient safety information and the dopamine effects of levodopa.

You should also avoid it while breastfeeding—levodopa can lower prolactin and reduce milk supply, which could affect nursing.

Side effects, ingredient by ingredient Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on any of these: older antidepressants called MAOIs, methyldopa or guanethidine (blood pressure medications), levodopa (Parkinson's disease), blood sugar medications, antipsychotic drugs, or tricyclic antidepressants. Also let your surgeon know if you're taking it and are scheduled for surgery—some anesthetics don't mix well with the levodopa in this product.

Altogether, these interactions span 193 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a single-ingredient supplement containing levodopa from mucuna pruriens. It interacts with several important medications, especially older antidepressants and blood pressure drugs, so checking with your own doctor or pharmacist before starting is essential.

The evidence for its effectiveness in common uses is still insufficient. If you're already taking levodopa for Parkinson's disease or any of the medications listed in the Med Watch section, this product isn't for you without medical approval.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Mucuna Pruriens 1000 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X002BYWPUR
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307348
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Mucuna Pruriens 1000 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
100
UPC/BARCODE
X002BYWPUR
IngredientAmount% DV
Mucuna pruriens Seed Extract, Natural1000 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silica, Rice, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mucuna Pruriens 1000mg per serving

General Statements

New

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Assembled in USA Tested Supports nutritional supplementation Guaranteed quality, laboratory tested Made under strict GMP guidelines Max strength

Suitable for vegetarians/vegans

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium quality Assembled in USA GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Manufactured in a cGMP inspected facility

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Mucuna Pruriens 1000 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Mucuna Pruriens 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Mucuna Pruriens 1000 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Mucuna pruriens Seed Extract, Natural

Interacts with
193 drugs
1000 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna pruriens Seed Extract, Natural monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silica, Rice, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Mucuna Pruriens 1000 mg by NusaPure Drug Interactions

Want to check YOUR meds against Natural Mucuna Pruriens 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

Mucuna pruriens Seed Extract, Natural 193

Individual Drug Interactions

The ingredients in Natural Mucuna Pruriens 1000 mg interact with 193 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Mucuna Pruriens 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Mucuna pruriens Seed Extract, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Mucuna Pruriens 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mucuna pruriens Seed Extract, Natural8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens Seed Extract, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Mucuna Pruriens 1000 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Natural Mucuna Pruriens 1000 mg by NusaPure: Common Questions

Does Natural Mucuna Pruriens 1000 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Natural Mucuna Pruriens 1000 mg has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Mucuna Pruriens 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is mucuna pruriens and why is it in here?
Mucuna pruriens is a tropical plant seed that naturally contains levodopa, a compound your body converts to dopamine. It's included in supplements aimed at supporting mood and neurological health, though evidence for these specific uses is still developing.
Can I take this if I'm on Parkinson's medication?
No—if you're already taking levodopa for Parkinson's disease, adding this product could increase your risk of side effects from the levodopa itself. Check with your doctor before combining them.
Is it safe during pregnancy?
The safety data advises against it during pregnancy. There isn't enough safety information, and the dopamine effects of levodopa are a concern. Talk with your doctor about whether this is right for you.
What side effects might I notice?
Most people tolerate it well, but some report diarrhea, gas, dry mouth, nausea, stomach bloating, vomiting, or headaches. About 3% of people in clinical trials reported trouble sleeping.
Can I breastfeed while taking this?
No—levodopa can lower prolactin and reduce milk supply. If you're nursing, this product is best avoided. Talk with your doctor or pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Mucuna Pruriens 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Mucuna Pruriens 1000 mg label
Go deeper

The Full Monographs Behind Natural Mucuna Pruriens 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Natural Mucuna Pruriens 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team