Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Neuro Fuel Ingredients & Drug Interactions

by NS Natural Stacks

Neuro Fuel label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Neuro Fuel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Neuro Fuel is a dietary supplement by NS Natural Stacks with 5 active ingredients. Its ingredients are commonly taken for depression and mood, skin condition vitiligo, pain conditions.Based on those ingredients, 1,121 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Coleus forskohlii Root Extract, Artichoke Leaf Extract, Vitamin B-6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Neuro Fuel by NS Natural Stacks

Ask about any prescription or over-the-counter medication and we check it for interactions with Neuro Fuel by NS Natural Stacks — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Neuro Fuel by NS Natural Stacks

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Neuro Fuel contains five active ingredients. L-Phenylalanine is an amino acid your body uses to make neurotransmitters and proteins.

Acetyl-L-Carnitine supports energy production in cells and brain function. Vitamin B6 is essential for brain chemistry and nerve health.

Coleus forskohlii root extract contains forskolin, a compound that affects cell signaling. Artichoke leaf extract provides compounds that support digestion and liver function.

The product also contains inactive ingredients—hypromellose (capsule material), ascorbyl palmitate (a preservative form of vitamin C), and silica (an anti-caking agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Brain function, Mental clarity, Focus.
  • The strongest evidence on file: Acetyl-l-carnitine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Acetyl-l-carnitine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Vitamin B6 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.

The evidence for Neuro Fuel's ingredients is mixed. Vitamin B6 is well-established as effective for B6 deficiency, sideroblastic anemia, and pyridoxine-dependent epilepsy, and possibly effective for reducing high homocysteine levels and pregnancy-related nausea.

Acetyl-L-Carnitine is possibly effective for age-related cognitive decline, Alzheimer disease, diabetic nerve pain, and depression. Artichoke leaf extract is possibly effective for high cholesterol and indigestion.

L-Phenylalanine shows possibly effective evidence only for vitiligo and possibly ineffective evidence for ADHD. Coleus and several other uses lack sufficient reliable evidence to rate.

The evidence base is strongest for vitamin B6 and weakest for coleus.

The evidence, ingredient by ingredient Phenylalanine Acetyl-l-carnitine Vitamin B6 Coleus Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at typical doses but can damage nerves (sensory neuropathy) at high doses over time, especially above 1,000 mg daily. L-Phenylalanine is generally well tolerated in food amounts but may cause anxiety, insomnia, headache, nausea, constipation, or sedation at supplement doses.

It must be avoided entirely by people with phenylketonuria (PKU). Acetyl-L-Carnitine is generally well tolerated short-term, though long-term safety isn't fully established; side effects may include agitation, headache, insomnia, reduced appetite, nausea, or a fishy-smelling odor.

Coleus is generally well tolerated but may cause diarrhea, nausea, constipation, or vomiting, and lowers blood pressure. Artichoke is generally well tolerated; side effects may include abdominal pain, diarrhea, gas, or nausea.

Rarely, allergic reactions including anaphylaxis can occur in people sensitive to plants in the daisy family. Supplement doses of L-Phenylalanine, Acetyl-L-Carnitine, Coleus, and Artichoke are not recommended during pregnancy or breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Phenylalanine Acetyl-l-carnitine Vitamin B6 Coleus Artichoke

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Phenylalanine, Acetyl-l-carnitine, Artichoke, Vitamin B6, Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Neuro Fuel, check with your pharmacist if you take any of these: levodopa (Parkinson disease), nitrates or calcium channel blockers (heart and blood pressure), blood thinners or antiplatelet drugs like warfarin or aspirin, seizure medications such as phenobarbital or phenytoin, antidepressants including older MAOIs or serotonergic drugs, muscle relaxants like baclofen, thyroid hormone replacement, blood pressure medications, diabetes medications, or the heart rhythm drug amiodarone. The ingredient interactions are documented across these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Neuro Fuel may appeal to someone seeking cognitive or energy support from natural ingredients with some research backing. However, it's not right for you if you take levodopa, nitrates, calcium channel blockers, blood thinners, seizure medications, or older antidepressants (MAOIs).

Anyone on any prescription medication should check their exact drugs with our interaction tool before starting. Talk with your pharmacist—the interaction profile is broad enough that individual review is essential.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neuro Fuel, straight from the product label.

Brand NS Natural Stacks
Barcode (UPC) 673869563964
Net contents 45 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274242
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neuro Fuel by NS Natural Stacks, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
15
UPC/BARCODE
673869563964
IngredientAmount% DV
L-Phenylalanine500 mg--
Acetyl-L-Carnitine750 mg--
Vitamin B-65 mg294%
Coleus forskohlii Root Extract20 mg--
Artichoke Leaf Extract900 mg--

Other ingredients: Hypromellose, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 2-3 capsules in the morning immediately upon waking on an empty stomach, or as directed by a healthcare practitioner. Do not take more than 3 capsules per day.

General Statements

Certified Open Source: Scan for ingredient supplier information and 3rd party lab test results.

Precautions

Warning: Discontinue use two weeks prior to surgery. Do not use if you have phenylketonuria (PKU).

Do not consume prescription stimulants with Neuro Fuel. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.

Do not use if safety seal is broken or missing.

Keep out of reach of children.

Do not use if pregnant, nursing, or under the age of 18.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Certified Open Source Full Label Disclosure U.S.A. manufactured in a cGMP certified facility.

Formulation

Focus & memory support for a better brain

The original CILTEP formula.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Neuro Fuel is a patented formula featuring the highest quality natural ingredients. Neuro Fuel is protected under U.S. Patent 9149457B2 and 10058529B2.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Neuro Fuel by NS Natural Stacks label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Neuro Fuel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Neuro Fuel by NS Natural Stacks

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Phenylalanine

Interacts with
16 drugs
500 mg per serving

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...

L-Phenylalanine monograph & interactions

Acetyl-L-Carnitine

Interacts with
203 drugs
750 mg per serving Form: Acetyl-L-Carnitine HCl

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl-L-Carnitine monograph & interactions

Vitamin B-6

Interacts with
210 drugs
5 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B-6 monograph & interactions

Coleus forskohlii Root Extract

Interacts with
915 drugs
20 mg per serving Form: Forskolin

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Coleus forskohlii Root Extract monograph & interactions

Artichoke Leaf Extract

Interacts with
363 drugs
900 mg per serving Form: Cynarin

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke Leaf Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Neuro Fuel by NS Natural Stacks Drug Interactions

Want to check YOUR meds against Neuro Fuel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,121Drugs
34 Major 1,087 Moderate

Ingredients driving the most interactions

Coleus forskohlii Root Extract 915
Artichoke Leaf Extract 363
Vitamin B-6 210
Acetyl-L-Carnitine 203
L-Phenylalanine 16

Individual Drug Interactions

The ingredients in Neuro Fuel interact with 1,121 drugs. Click any drug to see the details.

5 of the 5 ingredients in Neuro Fuel interact with drugs. Each result below shows which ingredient is responsible. Coleus forskohlii Root Extract Artichoke Leaf Extract Vitamin B-6 Acetyl-L-Carnitine L-Phenylalanine

Each ingredient & the kinds of drugs it affects

For each ingredient in Neuro Fuel with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coleus forskohlii Root Extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii Root Extract full monograph & interactions

Artichoke Leaf Extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke Leaf Extract full monograph & interactions

Vitamin B-65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B-6 full monograph & interactions

Acetyl-L-Carnitine4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl-L-Carnitine full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Neuro Fuel, from the product label.

NS Natural Stacks

See all NS Natural Stacks products
Name
NS 360, Inc.
Street Address
4241 24th Ave W
City
Seattle
State
WA
ZipCode
98199
Phone Number
1-855-678-2257
Web Address
www.naturalstacks.com
Pharmacist Counseling Corner

Neuro Fuel by NS Natural Stacks: Common Questions

Does Neuro Fuel by NS Natural Stacks interact with any medications?
Yes. Based on its ingredients, Neuro Fuel has a known interaction with 1,121 medications, including 34 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neuro Fuel contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Neuro Fuel actually improve memory or thinking?
The evidence varies by ingredient. Acetyl-L-Carnitine is possibly effective for age-related cognitive decline and Alzheimer disease. Vitamin B6 supports brain chemistry but is rated effective mainly for deficiency states. L-Phenylalanine shows no solid evidence for ADHD. Coleus and artichoke don't have enough research to rate. It's not a proven memory booster across the board.
Can I take Neuro Fuel if I'm pregnant or breastfeeding?
No. Supplement doses of L-Phenylalanine, Acetyl-L-Carnitine, Coleus, and Artichoke are not recommended during pregnancy or breastfeeding because safety data is insufficient. Talk with your doctor before taking any supplement while pregnant or nursing.
What's the most common side effect I should watch for?
Diarrhea is common with Coleus and Artichoke. L-Phenylalanine and Acetyl-L-Carnitine may cause nausea, headache, or insomnia. Vitamin B6 at normal doses is well tolerated but can cause nerve damage at high doses over time. Start with a low dose and watch how you feel.
Is this product safe for someone with PKU?
No. L-Phenylalanine must be avoided entirely by anyone with phenylketonuria (PKU). If you have PKU or a family history of it, do not take Neuro Fuel.
Does Neuro Fuel contain any fillers or artificial ingredients?
The product contains three inactive ingredients: hypromellose (the capsule), ascorbyl palmitate (a form of vitamin C used as a preservative), and silica (to prevent caking). These are typical capsule materials and not considered fillers in the sense of inert bulk.
What does Coleus actually do in this formula?
Coleus forskohlii contains forskolín, which affects cell signaling and theoretically may lower blood pressure and support circulation. However, there isn't enough reliable evidence to rate whether it works for any specific condition. It's included for potential cognitive or circulatory support, but solid proof is lacking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neuro Fuel label
Go deeper

The Full Monographs Behind Neuro Fuel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Neuro Fuel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
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Acetyl-l-carnitine 22 references
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Vitamin B6 32 references
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Coleus 16 references
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Artichoke 16 references
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