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Dietary supplement

OmniZen Ingredients & Drug Interactions

by PEScience

OmniZen label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OmniZen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OmniZen is a dietary supplement by PEScience with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 581 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine, Cyracos. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OmniZen by PEScience

Ask about any prescription or over-the-counter medication and we check it for interactions with OmniZen by PEScience — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of OmniZen by PEScience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

OmniZen contains 2 active ingredients: L-theanine, an amino acid that may support brain function and relaxation, and Cyracos (a lemon balm extract), used traditionally for stress and mood support. The capsules also include inactive ingredients — hydroxypropyl methylcellulose, silicon dioxide, and magnesium stearate — which are fillers and processing aids.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: calm, relaxation and stress relief.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, nervousness, restlessness.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

For L-theanine, the evidence shows it is possibly effective for cognitive function; however, the data is insufficient to rate its effectiveness for age-related cognitive decline, Alzheimer's disease, generalized anxiety, obsessive-compulsive disorder, or cancer. Lemon balm (Cyracos) is possibly effective for cold sores, stress, and depression based on the studies we hold.

Neither ingredient has strong evidence for all the uses people might expect from this product.

The evidence, ingredient by ingredient Theanine Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated in healthy adults for short-term use, though long-term safety hasn't been well studied. Reported side effects include headaches, drowsiness, increased sleep duration, and increased dream activity.

For lemon balm, it's generally well tolerated short-term, but high doses and long-term safety are not well established. Dizziness and sedation have been reported orally, though they don't appear more frequent than placebo; topical use has caused mild irritation in rare cases.

Regarding pregnancy: there isn't enough safety data for L-theanine, so it's best to avoid it during pregnancy and breastfeeding unless your doctor advises otherwise. For lemon balm, safety data in pregnancy is also limited — avoid it unless your doctor says it's okay — and use caution while breastfeeding.

Talk with your doctor or pharmacist about whether either ingredient is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Theanine Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lemon Balm, Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 581 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking OmniZen, double-check it with your doctor or pharmacist if you're on thyroid hormone replacement therapy (lemon balm may interfere) or blood pressure medications (L-theanine may lower blood pressure further). Also flag it if you take sedatives, sleep aids, opioids, or serotonergic antidepressants, since both ingredients could potentially add to their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

OmniZen may appeal to those looking to support stress and cognitive function, but it's not for everyone. If you take blood pressure medications, thyroid replacements, sedatives, or antidepressants, you need to clear this product with your doctor or pharmacist first.

It's not recommended during pregnancy or breastfeeding without medical guidance. Have a conversation with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OmniZen, straight from the product label.

Brand PEScience
Barcode (UPC) 040232288777
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 297406
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OmniZen by PEScience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
040232288777
IngredientAmount% DV
L-Theanine100 mg--
Cyracos300 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule in the morning and 1 capsule at night with or without food.

Use with REM-3 for sleep support

Precautions

Warnings: This product is intended to be consumed by healthy adults.

Consult with a physician before using this product, especially if you are taking any prescription or over the counter medication, or have any pre-existing medical condition. Pregnant or nursing women should not use this product without first consulting with a physician.

Do not take this product if you take selective serotonin reuptake inhibitors (SSRIs). Discontinue use 2 weeks prior to surgery. Discontinue use and immediately consult your healthcare professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

300 mg lemon balm 100 mg theanine

Clinically studied Cyracos Lemon Balm L-theanine 100 mg

OmniZen is a non-stimulating, calming formula that supports mood & stress with a clinically studied extract of lemon balm leaf combined with theanine.

General Statements

30 day supply

Formulation

Calming formula Stress & mood support

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Cyracos is a registered trademark of Naturex

Seals/Symbols

Lab Tested Third Party Tested For Quality And Purity pescience.com/difference

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OmniZen by PEScience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OmniZen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OmniZen by PEScience

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
100 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Cyracos

Interacts with
264 drugs
300 mg per serving Form: Lemon Balm leaf extract

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Cyracos monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

OmniZen by PEScience Drug Interactions

Want to check YOUR meds against OmniZen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
581Drugs
435 Moderate 146 Minor

Ingredients driving the most interactions

L-Theanine 565
Cyracos 264

Individual Drug Interactions

The ingredients in OmniZen interact with 581 drugs. Click any drug to see the details.

2 of the 2 ingredients in OmniZen interact with drugs. Each result below shows which ingredient is responsible. L-Theanine Cyracos

Each ingredient & the kinds of drugs it affects

For each ingredient in OmniZen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Cyracos2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Cyracos full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OmniZen, from the product label.

PEScience

See all PEScience products
Name
PEScience LLC
Street Address
3665 East Bay Dr #204-155
City
Largo
State
FL
Phone Number
888-885-0195
Web Address
pescience.com
Pharmacist Counseling Corner

OmniZen by PEScience: Common Questions

Does OmniZen by PEScience interact with any medications?
Yes. Based on its ingredients, OmniZen has a known interaction with 581 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OmniZen contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-theanine, and what does it do?
L-theanine is an amino acid that may support cognitive function. It's possibly effective for that purpose based on available research, though evidence for other uses like anxiety or age-related cognitive decline is too limited to rate.
What's lemon balm (Cyracos) in here for?
Lemon balm is included for stress, mood, and cold sore support. The evidence shows it's possibly effective for those three uses based on the studies we have.
Is OmniZen safe if I'm pregnant or breastfeeding?
There isn't enough safety data for either L-theanine or lemon balm during pregnancy, so it's best to avoid this product unless your doctor says otherwise. Breastfeeding also carries caution — talk with your doctor or pharmacist before using it.
What side effects might I experience?
L-theanine may cause headaches, drowsiness, increased sleep time, or vivid dreams. Lemon balm might cause dizziness or sedation, though these don't appear to happen more often than with placebo. Both are generally well tolerated short-term.
How long is it safe to take OmniZen?
Both ingredients are generally well tolerated for short-term use in healthy adults, but long-term safety hasn't been well studied. Talk with your doctor about how long you should take it.
Can I take this with my blood pressure medication?
L-theanine may lower blood pressure further, intensifying your medication's effect — a Moderate concern. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OmniZen label
Go deeper

The Full Monographs Behind OmniZen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

OmniZen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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