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Dietary supplement

OncoPLEX Ingredients & Drug Interactions

by XYMOGEN

OncoPLEX label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OncoPLEX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OncoPLEX is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are TrueBroc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OncoPLEX by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with OncoPLEX by XYMOGEN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OncoPLEX by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

OncoPLEX contains one active ingredient: broccoli (branded as TrueBroc). This is a concentrated extract of broccoli, the cruciferous vegetable.

The supplement also includes several inactive ingredients—microcrystalline cellulose, hypromellose, water, stearic acid, magnesium stearate, and silica—which are fillers, binders, and capsule materials that help deliver the broccoli powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence for broccoli in cancer prevention and treatment is mixed. For colorectal cancer, broccoli is rated possibly effective—meaning there's some evidence it may help, but more research is needed.

For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the evidence is insufficient to rate. In plain terms: broccoli shows promise for colorectal cancer, but we don't have strong enough data yet to say it works for the other conditions listed.

Talk with your doctor about how this fits into your overall health plan.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is safe for most people. However, concentrated broccoli supplements are less studied than the whole vegetable, and the safety data for extracts isn't as established.

The main caution is to avoid concentrated supplements unless your doctor approves them. Some people have reported loose stools, diarrhea, belly pain, and cramping after taking broccoli seed and sprout extracts, especially at higher doses.

Topical exposure can occasionally trigger allergic reactions like contact dermatitis. If you're pregnant or nursing, broccoli is rated likely safe, but confirm with your doctor or pharmacist before starting any new supplement.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medications broken down by your liver's CYP1A2 or CYP2A6 enzymes—including certain blood pressure drugs, heart medications, and others—you'll want to flag this with your doctor or pharmacist. Both interactions are moderate in severity.

They'll help you figure out if you need to adjust timing or dosing, or whether this supplement is right for you at all.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

OncoPLEX may interest you if you're exploring dietary approaches to colorectal cancer support, but the evidence for other cancer types is still limited. The main thing to watch is whether you take medications processed by your liver—broccoli can reduce their effectiveness.

Check your medications with the tool on this page and talk it over with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OncoPLEX, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149001384
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 303793
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OncoPLEX by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
871149001384
IngredientAmount% DV
TrueBroc30 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Water, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule daily, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Formula

TrueBroc broccoli seed extract is obtained using a patented process to extract glucoraphanin (also known as sulforaphane glucosinolate or "sgs") from its most concentrated cruciferous source - broccoli seeds. Glucoraphanin is enzymatically converted to the extensively researched isothiocyanate known as sulforaphane (SFN). Research suggests that SFN supports long-lasting antioxidant activity, and the production of detoxification enzymes. It also extends support to the immune, nervous, and cardiovascular systems, addressing the maintenance of good health throughout adult life. OncoPLEX provides 30 mg of glucoraphanin per capsule.

Glucoraphanin Clinically tested

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

Formulated to Exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Vegetarian Caps

Brand IP Statement(s)

S1. TrueBroc is protected by trademarks and patents of Brassica Protection Products LLC: www.brassica.com/ip

Xymogen Exclusive Professional Formulas

Copyright 2022 Xymogen

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

ePV (ePedigree Verification) Vegetarian Caps Third-Party Verified GMP Compliant

General Statements

Scan to Learn More! This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OncoPLEX by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OncoPLEX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OncoPLEX by XYMOGEN

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

TrueBroc

Interacts with
187 drugs
30 mg per serving Form: Glucoraphanin

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Water, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

OncoPLEX by XYMOGEN Drug Interactions

Want to check YOUR meds against OncoPLEX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

TrueBroc 187

Individual Drug Interactions

The ingredients in OncoPLEX interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in OncoPLEX interact with drugs. Each result below shows which ingredient is responsible. TrueBroc

Each ingredient & the kinds of drugs it affects

For each ingredient in OncoPLEX with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OncoPLEX, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

OncoPLEX by XYMOGEN: Common Questions

Does OncoPLEX by XYMOGEN interact with any medications?
Yes. Based on its ingredients, OncoPLEX has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OncoPLEX contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is TrueBroc?
TrueBroc is a concentrated broccoli extract. It's the active ingredient in OncoPLEX and contains the natural compounds found in broccoli, including glucosinolates—substances responsible for many of broccoli's effects in your body.
Does this supplement really help with cancer?
For colorectal cancer, broccoli is rated possibly effective, meaning some evidence supports it but more research is needed. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer listed here, the evidence isn't strong enough yet to make a clear call. Talk with your oncologist or doctor about how this fits with your treatment plan.
Can I take this if I'm pregnant or nursing?
Broccoli is rated likely safe during pregnancy and lactation. Still, run it past your doctor or midwife before you start—they'll want to know about any supplements you're considering, especially if you're taking other medications.
What side effects should I watch for?
Most people tolerate it well. The main reported side effects are loose stools, diarrhea, belly pain, and cramping, particularly at higher doses of broccoli seed or sprout extracts. Topical exposure can rarely trigger allergic reactions. If you notice any of these, dial back the dose or stop and talk with your pharmacist.
Is this just dried broccoli, or is it different from eating broccoli?
OncoPLEX is a concentrated extract, so it's more potent than eating fresh broccoli. While broccoli as a food is safe in normal amounts, concentrated supplements aren't as well studied, so check with your doctor before starting unless they've already approved it.
Will this interfere with my medications?
Broccoli can speed up how your liver breaks down certain drugs, potentially making them less effective. The biggest concern is with medications processed by CYP1A2 and CYP2A6 enzymes. Use the medication checker on this page with your exact drugs, and talk with your pharmacist or doctor before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OncoPLEX label
Go deeper

The Full Monographs Behind OncoPLEX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

OncoPLEX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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