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Dietary supplement

OncoPLEX Ingredients & Drug Interactions

by XYMOGEN EP

OncoPLEX label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OncoPLEX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OncoPLEX is a dietary supplement by XYMOGEN EP with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OncoPLEX by XYMOGEN EP

Ask about any prescription or over-the-counter medication and we check it for interactions with OncoPLEX by XYMOGEN EP — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of OncoPLEX by XYMOGEN EP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

OncoPLEX contains one active ingredient: broccoli seed extract. The extract is standardized to deliver the glucosinolates that give broccoli its potential benefits.

The capsule also holds microcrystalline cellulose, HPMC, stearic acid, silicon dioxide, and magnesium stearate as inactive ingredients to hold it together and ensure it dissolves properly.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence for broccoli seed extract is mixed and depends on the cancer type. For colorectal cancer, the research suggests it may be effective, though more study is needed.

For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, we don't have enough reliable evidence yet to rate whether it works. If you're considering this for a specific health goal, talk with your doctor about what the current research supports and whether it fits your care plan.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is generally well tolerated in normal amounts. However, concentrated supplements like this extract are less studied than the whole food, and safety data for high-dose extracts isn't firmly established.

The most common side effects from broccoli seed and sprout extracts are loose stools, diarrhea, abdominal pain, and cramping—particularly at higher doses. Allergic contact reactions are possible if broccoli touches your skin.

The safety data shows broccoli seed extract is likely safe in pregnancy and lactation, but because concentrated extracts haven't been extensively studied, talk with your doctor or pharmacist before taking this if you're pregnant, nursing, or planning to be.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check any medications metabolized by the liver enzymes CYP2A6 or CYP1A2 (like certain pain relievers, antidepressants, and other drugs) with your pharmacist. Broccoli seed extract can reduce how well these medications work by speeding up how your body breaks them down.

Your own pharmacist or doctor can tell you if any of your specific prescriptions are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is worth considering if your doctor has discussed broccoli supplementation for colorectal cancer prevention or support, but it's not established for other cancers. The main risk is that it can speed up how your liver clears many medications—potentially making them less effective—so check your full medication list with the interaction tool here before you start.

Because concentrated extracts carry more uncertainty than eating broccoli as food, confirm with your own doctor or pharmacist that it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OncoPLEX, straight from the product label.

Brand XYMOGEN EP
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 6087
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OncoPLEX by XYMOGEN EP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Broccoli Seed Extract230 mg--

Other ingredients: Microcrystalline Cellulose, HPMC, Stearic Acid, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one capsule daily or as directed by your healthcare practitioner.

Precautions

CAUTION: Keep out of reach of children.

• Pharmaceutical Grade • Professional Use Only

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep tightly closed in a cool, dry place.

General Statements

Clinically Tested Worldwide

EXCLUSIVE • PATENTED

Produced under U.S. Patents 5,725,895; 5,968,505; 5,968,567; 6,277,122 and 6,242,018 licensed from Brassica Protection Products LLC; SGS is a trademark of Brassica Protection Products.

SULFORAPHANE GLUCOSINOLATE

This package is completely recyclable (recycle).

General

TC# D6750301 REV. 121010

Brand IP Statement(s)

XYMOGEN 2010

All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.

Each OncoPLEX(TM) capsule contains 30 mg sulforaphane glucosinolate (SGS(TM)). Scientists identified SGS(TM) as a natural long-lasting antioxidant and detoxifier found in broccoli and broccoli sprouts. SGS(TM) contributes to the integrity of all cells, promoting health and well-being. Since its discovery, more than 200 publications from universities worldwide have underscored the significance of sulforaphane glucosinolate. SGS(TM) activates the body’s natural detoxification and antioxidant enzymes, protecting cells from free radical damage.*

HIGHEST SGS(TM) CONCENTRATION

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, soy, animal or dairy products, artificial colors, sweeteners or preservatives.

Seals/Symbols

SGS THE LONG-LASTING ANTIOXIDANT

VEGETABLE CAPSULES

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OncoPLEX by XYMOGEN EP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OncoPLEX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OncoPLEX by XYMOGEN EP

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Broccoli Seed Extract

Interacts with
187 drugs
230 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli Seed Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, HPMC, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

OncoPLEX by XYMOGEN EP Drug Interactions

Want to check YOUR meds against OncoPLEX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Broccoli Seed Extract 187

Individual Drug Interactions

The ingredients in OncoPLEX interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in OncoPLEX interact with drugs. Each result below shows which ingredient is responsible. Broccoli Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in OncoPLEX with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli Seed Extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OncoPLEX, from the product label.

XYMOGEN EP

See all XYMOGEN EP products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
725 S. Kirkman Rd.
City
Orlando
State
FL
ZipCode
32811
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

OncoPLEX by XYMOGEN EP: Common Questions

Does OncoPLEX by XYMOGEN EP interact with any medications?
Yes. Based on its ingredients, OncoPLEX has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OncoPLEX contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The data we have suggests broccoli seed extract is likely safe in pregnancy and lactation. That said, concentrated supplements haven't been studied as thoroughly as whole broccoli, so there isn't enough information to be completely certain. Talk with your doctor or pharmacist about whether it's right for you during pregnancy or while nursing.
What are the most common side effects?
Loose stools, diarrhea, abdominal pain, and cramping have been reported, especially at higher doses. These digestive effects tend to be mild, but if they're bothersome, mention them to your pharmacist—they may suggest starting with a smaller dose.
Does broccoli seed extract actually work for cancer?
For colorectal cancer, the research suggests it may be effective, though more evidence is needed. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, we don't have enough reliable data to say whether it works. Talk with your doctor about what's supported for your specific situation.
Why do I need to check my medications with this supplement?
Broccoli seed extract speeds up how your liver metabolizes (breaks down) certain medications, which can lower their blood levels and make them less effective. With 187 medications potentially affected, it's important to run your prescriptions through the checker on this page.
How is this different from eating broccoli as food?
This is a concentrated extract, so it delivers a much higher dose of broccoli compounds than eating the vegetable normally would. Broccoli as food is safe in regular amounts, but concentrated supplements haven't been studied as well, so safety data is less complete.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OncoPLEX label
Go deeper

The Full Monographs Behind OncoPLEX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

OncoPLEX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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