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Dietary supplement

Periwinkle 650 mg Ingredients & Drug Interactions

by Nature's Answer

Periwinkle 650 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Periwinkle 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Periwinkle 650 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, circulation problems, dizziness and ringing in the ears.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Periwinkle (Vinca minor) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Periwinkle 650 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Periwinkle 650 mg by Nature's Answer — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Periwinkle 650 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: periwinkle (Vinca minor) aerial parts extract, supplying 650 mg per dose. Periwinkle is a traditional plant used to support circulation and cognitive function, though the evidence for those uses isn't established in our data.

The liquid form also contains purified water, vegetable glycerin, and 12–15% certified organic alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Periwinkle product and its label doesn't state a use — see Periwinkle's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no established effectiveness ratings for periwinkle in our data, so we cannot tell you whether it reliably delivers the benefits it's marketed for.

The evidence, ingredient by ingredient Periwinkle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Periwinkle is generally regarded as unsafe for oral use. Because it contains potent vinca alkaloids — compounds that can be toxic — it carries real risks of liver damage, kidney damage, nervous system damage, gastrointestinal upset, skin flushing, and dangerously low blood pressure, especially as doses increase.

The safety data advises against use during pregnancy and while breastfeeding due to its strong alkaloids and insufficient safety information. Given these risks, periwinkle should only be used under professional medical guidance.

If you're considering this product, talk with your doctor or pharmacist first.

Side effects, ingredient by ingredient Periwinkle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Periwinkle.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medication (antihypertensive drugs), check with your doctor or pharmacist before using this product. Periwinkle may increase the blood-pressure-lowering effect and cause your blood pressure to drop too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Periwinkle is generally regarded as unsafe for oral use and carries real risks of organ damage and dangerous drops in blood pressure. It also interacts with a large number of blood pressure medications.

If you're taking any blood pressure medication, or if you have liver or kidney concerns, this product requires a conversation with your doctor or pharmacist before you start — not after.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Periwinkle 650 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004605
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 59256
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Periwinkle 650 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
083000004605
IngredientAmount% DV
Periwinkle (Vinca minor) aerial parts extract650 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Gluten Free

K Parve

Bio-Chelated Cold Extraction Process

Formula

K Parve

Vinca minor

Low Alcohol

General

9276 Rev. 914

Brand IP Statement(s)

Advanced Botanical Fingerprint

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

2014 Nature's Answer

General Statements

Super Concentrated 650 mg

Our facility is cGMP certified, organic and kosher certified.

Since 1972

Formulation

Gluten-Free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1/2-1 mL (14-28 drops) 2-3 times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Periwinkle 650 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Periwinkle 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Periwinkle 650 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Periwinkle (Vinca minor) aerial parts extract

Interacts with
172 drugs
650 mg per serving

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evi...

Periwinkle (Vinca minor) aerial parts extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Periwinkle 650 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Periwinkle 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Periwinkle (Vinca minor) aerial parts extract 172

Individual Drug Interactions

The ingredients in Periwinkle 650 mg interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Periwinkle 650 mg interact with drugs. Each result below shows which ingredient is responsible. Periwinkle (Vinca minor) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Periwinkle 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Periwinkle (Vinca minor) aerial parts extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle.

Likelihood Probable Evidence D
Periwinkle (Vinca minor) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Periwinkle 650 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Periwinkle 650 mg by Nature's Answer: Common Questions

Does Periwinkle 650 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Periwinkle 650 mg has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Periwinkle 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against periwinkle during pregnancy and while breastfeeding due to its potent alkaloids and insufficient safety information. Talk with your doctor or pharmacist about alternatives.
What side effects has periwinkle been reported to cause?
Periwinkle can cause liver, kidney, and nervous system damage; gastrointestinal upset; skin flushing; and dangerously low blood pressure. Because it contains toxic vinca alkaloids, it's generally regarded as unsafe for oral use.
Why does the product say to use it only with professional advice?
Periwinkle's vinca alkaloids are potent and can be toxic at higher doses. Professional guidance helps ensure you're using it safely and that it won't harm your liver, kidneys, or nervous system.
What is vincamine, and why does it matter for blood pressure?
Vincamine is an alkaloid in periwinkle that naturally lowers blood pressure. If you're already on blood pressure medication, adding periwinkle may cause your blood pressure to drop too far.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Periwinkle 650 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Periwinkle 650 mg label
Go deeper

The Full Monographs Behind Periwinkle 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Periwinkle

Interacts with 172 drugs

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evidence in humans is limited and mixed, an...

Read the full Periwinkle monograph →
Sources

Sources & How We Checked

Periwinkle 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Periwinkle 5 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Periwinkle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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