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Dietary supplement

Periwinkle Alcohol Free Ingredients & Drug Interactions

by Herbal Terra

Periwinkle Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Periwinkle Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Periwinkle Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, circulation problems, dizziness and ringing in the ears.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Periwinkle Leaf Extract, Dry, Raw. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Periwinkle Alcohol Free by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Periwinkle Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Periwinkle Alcohol Free by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: periwinkle leaf extract (dry, raw form). Periwinkle is a plant traditionally used in herbal medicine, and its active compounds include alkaloids with effects on blood vessels and circulation.

The rest of the liquid is made up of glycerin and water, which are inactive ingredients that serve as the liquid base.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Memory and cognitive support, circulation.
  • We looked for evidence on: cognitive decline, memory, circulation, dizziness.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness ratings on file for periwinkle leaf extract. That means the evidence for what this product is intended to do isn't established in the data we hold.

If you're considering it for a specific condition, that's a good question to bring to your pharmacist or doctor.

The evidence, ingredient by ingredient Periwinkle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Periwinkle is regarded as unsafe for oral use because its alkaloids—the compounds that give it its effects—can damage your liver, kidneys, and nervous system, especially at higher doses. It can also cause skin flushing, stomach upset, and low blood pressure.

The safety notes make clear this should only be used with professional guidance. The ingredient is unsafe during pregnancy and while breastfeeding due to those potent alkaloids and lack of safety data.

If you're pregnant, planning pregnancy, or nursing, this product isn't recommended.

Side effects, ingredient by ingredient Periwinkle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Periwinkle.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medications (antihypertensive drugs), you need to check with us or your pharmacist before using this product. Periwinkle may strengthen their effect and drop your pressure too low.

Run your exact medications through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product carries real safety and interaction concerns. Because it can lower blood pressure and contains strong compounds that may harm your liver and kidneys, it should only be used under professional supervision.

Talk to your pharmacist or doctor before you start—especially if you take any blood pressure medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Periwinkle Alcohol Free, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7238360480382
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 324446
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Periwinkle Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
7238360480382
IngredientAmount% DV
Periwinkle Leaf Extract, Dry, Raw1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.

Natural Gluten free

Formula

Vinca minor

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Periwinkle Alcohol Free by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Periwinkle Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Periwinkle Alcohol Free by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Periwinkle Leaf Extract, Dry, Raw

Interacts with
172 drugs
1156 mg per serving Form: Vinca minor Leaf Extract, Dry, Raw

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evi...

Periwinkle Leaf Extract, Dry, Raw monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Periwinkle Alcohol Free by Herbal Terra Drug Interactions

Want to check YOUR meds against Periwinkle Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Periwinkle Leaf Extract, Dry, Raw 172

Individual Drug Interactions

The ingredients in Periwinkle Alcohol Free interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Periwinkle Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Periwinkle Leaf Extract, Dry, Raw

Each ingredient & the kinds of drugs it affects

For each ingredient in Periwinkle Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Periwinkle Leaf Extract, Dry, Raw1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle.

Likelihood Probable Evidence D
Periwinkle Leaf Extract, Dry, Raw full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Periwinkle Alcohol Free, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Periwinkle Alcohol Free by Herbal Terra: Common Questions

Does Periwinkle Alcohol Free by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Periwinkle Alcohol Free has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Periwinkle Alcohol Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Periwinkle is unsafe during pregnancy and while breastfeeding because of its potent alkaloids and lack of safety data. Do not use this product in either case.
What does periwinkle actually do?
We don't have effectiveness ratings for periwinkle in our data, so I can't tell you what the evidence supports it for. Your pharmacist or doctor can help you figure out whether this is the right choice for what you're trying to address.
Is periwinkle safe to use regularly?
Periwinkle is regarded as unsafe for regular oral use. Its alkaloids can damage your liver, kidneys, and nervous system, especially over time or at higher doses. It should only be used with professional guidance.
What side effects should I watch for?
Periwinkle can cause skin flushing, stomach upset, and low blood pressure. Because of its toxicity, it can also cause damage to your liver, kidneys, and nervous system. These are serious reasons to use it only under professional supervision.
Does this product have any fillers or other inactive ingredients?
Yes. Glycerin and water make up the liquid base of this product—they're inactive ingredients. The only active ingredient is periwinkle leaf extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Periwinkle Alcohol Free is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Periwinkle Alcohol Free label
Go deeper

The Full Monographs Behind Periwinkle Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Periwinkle

Interacts with 172 drugs

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evidence in humans is limited and mixed, an...

Read the full Periwinkle monograph →
Sources

Sources & How We Checked

Periwinkle Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Periwinkle 5 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Periwinkle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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