Phena-Lean T2 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Phena-Lean T2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Phena-Lean T2 is a dietary supplement by Anabolic Warfare with 10 active ingredients. Its ingredients are commonly taken for exercise performance and recovery, heart health, weight management.Based on those ingredients, 1,242 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Evodiamine, Garcinia cambogia Fruit Rind Extract, Capsimax. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Phena-Lean T2 by Anabolic Warfare
Ask about any prescription or over-the-counter medication and we check it for interactions with Phena-Lean T2 by Anabolic Warfare — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Phena-Lean T2 by Anabolic Warfare
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Phena-Lean T2 contains 10 active ingredients. L-carnitine is an amino acid that supports energy production and may help with carnitine deficiency.
Garcinia cambogia Fruit Rind Extract is included for its hydroxycitric acid content. Capsimax is a capsicum (red pepper) extract.
The product also contains MitoBurn, T2 3,5-Diiodo-L-Thyronine (a thyroid-active compound), Paradoxine (grains of paradise), Emodin, Brown Seaweed Extract, Lean GBB, and Evodiamine (from evodia fruit). The capsules also contain inactive ingredients: gelatin, titanium dioxide, FD&C Blue #1, silicon dioxide, and magnesium stearate.
Does it work?
Moderate evidence
L-carnitine is effective for treating carnitine deficiency and possibly effective for high cholesterol and congestive heart failure. Garcinia, capsicum, T2 diiodothyronine, and evodia have insufficient reliable evidence to rate their effectiveness for the conditions listed.
We hold no effectiveness data for MitoBurn, Paradoxine, Emodin, Brown Seaweed Extract, or Lean GBB in our system.
How safe is it?
Well-documented data
L-carnitine is generally well tolerated at typical doses but can cause abdominal discomfort, diarrhea, nausea, heartburn, and a fishy body odor at higher doses. Garcinia is generally tolerated short-term but rare reports of liver injury warrant caution — it's not safe in pregnancy or while breastfeeding.
Capsicum is generally well tolerated in food amounts or at low supplement doses and is likely safe in pregnancy and while breastfeeding, though concentrated supplements are less well studied. T2 diiodothyronine is a thyroid-active compound with limited human safety data and should be avoided in pregnancy and while breastfeeding.
Paradoxine is likely safe in food amounts but lacks supplement safety data and should be avoided in pregnancy and breastfeeding. Evodiamine has limited human safety data, should be avoided in pregnancy, and lacks enough information for breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Phena-Lean T2, check with your pharmacist if you're on blood thinners (warfarin, acenocoumarol, or other anticoagulants and antiplatelet drugs) — moderate risk of increased bleeding. Also double-check thyroid hormone replacement, serotonergic antidepressants, antidiabetes medications, theophylline, QT-prolonging heart drugs, and any medications metabolized by liver enzymes — all carry documented moderate interactions with ingredients here.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient supplement with significant interaction potential, especially if you take blood thinners, thyroid hormone, antidepressants, diabetes or heart medications, or theophylline. Several ingredients have limited human safety data.
Talk with your pharmacist or doctor before starting, and run your full medication list through the interaction checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Phena-Lean T2, straight from the product label.
| Brand | Anabolic Warfare |
|---|---|
| Barcode (UPC) | 812575035949 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 316126 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Phena-Lean T2 by Anabolic Warfare, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Carnitine | 300 mg | -- |
| MitoBurn | 300 mg | -- |
| Garcinia cambogia Fruit Rind Extract | 150 mg | -- |
| Capsimax | 100 mg | -- |
| T2 3,5-Diiodo-L-Thyronine | 300 mcg | -- |
| Paradoxine | 10 mg | -- |
| Emodin | 200 mg | -- |
| Brown Seaweed Extract, Powder | 35 mg | -- |
| Lean GBB | 7.5 mg | -- |
| Evodiamine | 5 mg | -- |
Other ingredients: Gelatin, Titanium Dioxide, FD&C Blue #1, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use Take 2 capsules daily with 8-12 fl. oz. of water.
Formula
Benefits PhenaLean T2 is a non-stim thermogenic designed to support your body composition goals and promote feeling fuller for longer. MitoBurn, CapsiMax and T2 help to promote a natural energy boost without any caffeine to drive your workouts. Paradoxine, Brown Seaweed and Garcinia Cambogia combine to promote weight loss and support thyroid health to help you meet your goals.
Precautions
Warning: Do not exceed recommended dosage.
Not intended for anyone under the age of 18.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.
Keep out of reach of children.
Manufactured in a facility which processes milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soybeans, and sesame.
Storage
Store in a cool, dry & dark place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Dietary Supplement
General Statements
Facebook.com/anabolicwarfare Instagram @anabolicwarfare
Formulation
Non-Stim Thermogenic Formula Non-Stim Energy Boost Promotes Weight Loss Supports Thyroid Health
Seals/Symbols
cGMP Inspected Facility Good Manufacturing Practice
Brand IP Statement(s)
Capsimax is a registered trademark of OmniActive Health Technologies, Ltd. Paradoxine is a registered trademark of Win Health International Co., Ltd. Lean GBB is a registered trademark of NutraCap Labs, LLC. Mitoburn is a trademark of NNB Nutrition.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Phena-Lean T2 by Anabolic Warfare label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Phena-Lean T2 by Anabolic Warfare
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Carnitine
Interacts with19 drugs
L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...
L-Carnitine monograph & interactionsMitoBurn
Garcinia cambogia Fruit Rind Extract
Interacts with704 drugs
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...
Garcinia cambogia Fruit Rind Extract monograph & interactionsCapsimax
Interacts with239 drugs
Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...
Capsimax monograph & interactionsT2 3,5-Diiodo-L-Thyronine
No knowninteractions
Diiodothyronine (T2) is a thyroid hormone metabolite sold as a fat-loss and metabolism supplement, mostly in the bodybuilding world. Human evidence fo...
T2 3,5-Diiodo-L-Thyronine monograph & interactionsParadoxine
No knowninteractions
Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at m...
Paradoxine monograph & interactionsEmodin
Brown Seaweed Extract, Powder
Interacts with22 drugs
Ascophyllum nodosum (often sold as bladderwrack or brown seaweed) is a nutrient-rich algae that people use for weight, blood sugar, and thyroid suppor...
Brown Seaweed Extract, Powder monograph & interactionsLean GBB
Evodiamine
Interacts with950 drugs
Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain. Human evidence for these u...
Evodiamine monograph & interactionsOther (inactive) ingredients: Gelatin, Titanium Dioxide, FD&C Blue #1, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Phena-Lean T2 by Anabolic Warfare Drug Interactions
HelloPharmacist Interaction Report
Phena-Lean T2 by Anabolic Warfare contains multiple ingredients with documented interactions with medications.
The most serious concern is L-carnitine's moderate interaction with blood thinners (anticoagulants) like warfarin and acenocoumarol — it may increase their anticoagulant effects, raising your bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
The product also interacts with thyroid hormone replacement (L-carnitine may reduce its effectiveness), serotonergic drugs like certain antidepressants (garcinia, moderate risk of serotonin syndrome), anticoagulant and antiplatelet drugs (garcinia and capsicum, moderate bleeding risk), antidiabetes medications (garcinia and capsicum, moderate risk of low blood sugar), and theophylline (capsicum and evodia, moderate risk of elevated drug levels and side effects). Evodia raises additional moderate concerns with QT-prolonging heart drugs, CYP450-metabolized medications, and several enzyme-related interactions — this ingredient induces and inhibits liver pathways that affect how your body processes many common drugs.
We could not check MitoBurn, Emodin, Brown Seaweed Extract, or Lean GBB — we hold no interaction data for these. Altogether, these interactions span 1,220 individual medications.
Use the medication checker below with your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Phena-Lean T2?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Phena-Lean T2 interact with 1,242 drugs. Click any drug to see the details.
5 of the 10 ingredients in Phena-Lean T2 interact with drugs. Each result below shows which ingredient is responsible. Evodiamine Garcinia cambogia Fruit Rind Extract Capsimax Brown Seaweed Extract, Powder L-Carnitine
Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Caffeine, Codeine Phosphate interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Caffeine, Codeine Phosphate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionEvodiamineCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Read the full Evodiamine + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +2 Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Aspirin, Caffeine, Dover's Pwd interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Caffeine, Dover's Pwd interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Caffeine, Hydrocodone interactionEvodiamineCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Aspirin, Caffeine, Hydrocodone interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, evodia might decrease the levels and clinical effects of caffeine.
Read the full Evodiamine + Aspirin, Caffeine, Orphenadrine interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Caffeine, Orphenadrine interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEvodiamineAnticoagulant/antiplatelet Drugs, Caffeine +2 Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionGarcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Carisoprodol interactionCapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Carisoprodol interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Carisoprodol, Codeine Phosphate interactionCapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Carisoprodol, Codeine Phosphate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionGarcinia Cambogia Fruit Rind ExtractSerotonergic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionEvodiamineAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Citric Acid, Sodium Bicarbonate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Codeine Phosphate interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Codeine Phosphate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Codeine Phosphate, Methocarbamol interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Codeine Phosphate, Methocarbamol interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Codeine Phosphate, Phenobarbital interactionEvodiamineCytochrome P450 3a4 (cyp3a4) Inducers, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.
Read the full Evodiamine + Aspirin, Codeine Phosphate, Phenobarbital interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Diphenhydramine, Phenylpropanolamine interactionCapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Diphenhydramine, Phenylpropanolamine interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Dipyridamole interactionCapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Dipyridamole interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Ethoheptazine, Meprobamate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Ethoheptazine, Meprobamate interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Hydrocodone interactionCapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Hydrocodone interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Meprobamate interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Meprobamate interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Methocarbamol interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Methocarbamol interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
EvodiamineAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Inhibitors +1 Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Omeprazole interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Omeprazole interactionCapsimaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
CapsimaxAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsimax + Aspirin, Oxycodone interactionEvodiamineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Evodiamine + Aspirin, Oxycodone interactionGarcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Phena-Lean T2 — through 3 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aspirin, Pentazocine interactionCapsimaxAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsimax + Aspirin, Pentazocine interactionEvodiamineCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Read the full Evodiamine + Aspirin, Pentazocine interactionAstemizoleHismanal
How Astemizole interacts with Phena-Lean T2 — through 1 ingredient. Tap an ingredient for the detail:
EvodiamineQt Interval-prolonging Drugs Moderate
Interaction Summary
Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
Read the full Evodiamine + Astemizole interactionAtazanavirReyataz
How Atazanavir interacts with Phena-Lean T2 — through 1 ingredient. Tap an ingredient for the detail:
EvodiamineCytochrome P450 1a2 (cyp1a2) Inhibitors, Cytochrome P450 3a4 (cyp3a4) Inhibitors +1 Moderate
Interaction Summary
Theoretically, drugs that inhibit CYP1A2 might increase the levels and clinical effects of evodia.
Read the full Evodiamine + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Phena-Lean T2 — through 1 ingredient. Tap an ingredient for the detail:
EvodiamineCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 3a4 (cyp3a4) Inhibitors +1 Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Phena-Lean T2 — through 1 ingredient. Tap an ingredient for the detail:
EvodiamineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Phena-Lean T2 — through 2 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Atorvastatin interactionEvodiamineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Phena-Lean T2 — through 2 ingredients. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Atorvastatin Calcium interactionEvodiamineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodiamine + Atorvastatin Calcium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Phena-Lean T2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Evodiamine
Anticoagulant/Antiplatelet Drugs
Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro and animal studies show that rutaecarpine, a constituent of evodia, inhibits platelet aggregation.
Caffeine
Theoretically, evodia might decrease the levels and clinical effects of caffeine.
In animal models, evodia extract decreases caffeine levels by up to 71%. Evodia extract induces hepatic cytochrome P450 1A2 (CYP1A2) enzyme, of which caffeine is a substrate.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, evodia might decrease the levels and clinical effects of chlorzoxazone.
Animal research shows that administration of rutaecarpine, a constituent of evodia, with chlorzoxazone reduces the area under the curve (AUC) of chlorzoxazone by 84% and increases its clearance by 646%. This interaction is likely due to induction of cytochrome P450 2E1 (CYP2E1) by rutaecarpine .
Cytochrome P450 1A2 (Cyp1A2) Inhibitors
Theoretically, drugs that inhibit CYP1A2 might increase the levels and clinical effects of evodia.
The evodia constituent rutaecarpine is metabolized by CYP1A2.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Evodia extract and the evodia constituent rutaecarpine induce hepatic CYP1A2 enzyme activity. Evodia decreases levels of theophylline and caffeine, CYP1A2 substrates, by about 70% in animal models.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, evodia might reduce the levels and clinical effects of CYP2E1 substrates through induction of CYP2E1.
Animal research suggests that rutaecarpine, a constituent of evodia, induces CYP2E1 activity. In rats, rutaecarpine increases markers of CYP2E1 activity, and administration of rutaecarpine with chlorzoxazone, a known CYP2E1 substrate, reduces the area under the curve (AUC) of chlorzoxazone by 84% and increases its clearance by 646%.
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.
Animal research shows that concomitant administration of dexamethasone, a known CYP3A4 inducer, with the alkaloid constituents of evodia significantly reduces the area under the curve (AUC), maximum concentration (Cmax), and half-life of these constituents.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of evodia.
Animal research shows that concomitant administration of ketoconazole, a known CYP3A4 inhibitor, with the alkaloid constituents of evodia significantly increases the area under the curve (AUC), maximum concentration (Cmax), and half-life of these constituents.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that evodia extract inhibits hepatic CYP3A4. This effect has not been reported in humans.
Qt Interval-Prolonging Drugs
Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
Evodia has demonstrated dose-dependent activity as a proarrhythmic agent in animal and in vitro studies. Evodia infusion in animals extends the action duration potential and induces prolongation of the QT interval and Torsade de pointes.
Theophylline
Theoretically, evodia might decrease the levels and clinical effects of theophylline.
The evodia constituent rutaecarpine decreases theophylline levels and half-life by about 70% in animal models. This constituent appears to induce hepatic cytochrome P450 1A2 (CYP1A2) enzyme activity, of which theophylline is a substrate. Rutaecarpine is the primary active constituent of evodia; however, it is not known if the whole crude extract of evodia also causes this interaction.
Garcinia cambogia Fruit Rind Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.
Antidiabetes Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.
Hepatotoxic Drugs
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.
Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Capsimax
Anticoagulant/Antiplatelet Drugs
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.
Antidiabetes Drugs
Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.
Aspirin
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.
Theophylline
Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.
Ace Inhibitors (Aceis)
Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.
Ciprofloxacin (Cipro)
Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.
Brown Seaweed Extract, Powder
Amiodarone (Cordarone)
Theoretically, combining Ascophyllum nodosum with amiodarone might cause excessively high iodine levels.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Ascophyllum nodosum while using antithyroid drugs could alter the effects of the antithyroid drugs.
Thyroid Hormone
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Ascophyllum nodosum while using thyroid hormone could alter the effects of thyroid hormone.
L-Carnitine
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Brand information
Manufacturer and brand details for Phena-Lean T2, from the product label.
Anabolic Warfare
See all Anabolic Warfare products- Name
- Anabolic Warfare
- City
- Austin
- State
- TX
- Phone Number
- 888-301-4002
- Web Address
- anabolicwarfare.com
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Phena-Lean T2’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographGarcinia
Interacts with 704 drugsGarcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...
Read the full Garcinia monograph → Herb & supplement monographCapsicum
Interacts with 239 drugsCapsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...
Read the full Capsicum monograph → Herb & supplement monographDiiodothyronine
Diiodothyronine (T2) is a thyroid hormone metabolite sold as a fat-loss and metabolism supplement, mostly in the bodybuilding world. Human evidence for its safety and effectiveness is very l...
Read the full Diiodothyronine monograph → Herb & supplement monographGrains Of Paradise
Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at metabolism. Early human research suggests...
Read the full Grains Of Paradise monograph → Herb & supplement monographAscophyllum Nodosum
Interacts with 22 drugsAscophyllum nodosum (often sold as bladderwrack or brown seaweed) is a nutrient-rich algae that people use for weight, blood sugar, and thyroid support, but solid human evidence is limited f...
Read the full Ascophyllum Nodosum monograph → Herb & supplement monographEvodia
Interacts with 950 drugsEvodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain. Human evidence for these uses is very limited, and it is mostly st...
Read the full Evodia monograph →Sources & How We Checked
Phena-Lean T2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 197 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-carnitine 41 references
- Ellaway CM, Williams K, Leonard H, et al. Rett syndrome: randomized controlled trial of L-carnitine. J Child Neurol 1999;14:162-7. PubMed
- Anon. Carnitor (levocarnitine) package insert. Sigma-Tau Pharmaceuticals Inc, Gaithersburg, MD. December 1999.
- Cherchi A, Lai C, Angelino F, et al. Effects of L-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo-controlled, crossover study. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72.
- Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology 1997;35:16-23. PubMed
- Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
- Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
- Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
- Evans AM, Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharmacokinet 2003;42:941-67. PubMed
- 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
- Ciacci C, Peluso G, Iannoni E, et al. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Dig Liver Dis 2007;39:922-8. PubMed
- Cruciani RA, Dvorkin E, Homel P, et al. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. J Pain Symptom Manage 2006;32:551-9. PubMed
- Lebrun C, Alchaar H, Candito M, et al. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Mult Scler 2006;12:321-4. PubMed
- Malaguarnera M, Cammalleri L, Gargante MP, et al. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr 2007;86:1738-44. PubMed
- Mantovani G, Maccio A, Madeddu C, et al. Randomized phase III clinical trial of five different arms of treatment in 322 patients with cancer cachexia. Oncologist 2010;15:200-11.
- Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. J Eur Acad Dermatol Venereol. 2013 Jul PubMed
- Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. J Gastroenterol. Hepatol. 2014 May;29(5):997-1004. PubMed
- Boehm G, Stahl B. Oligosaccharides from milk. J Nutr 2007;137(3 Suppl 2):847S-849S.
- Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38. PubMed
- Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25(5):1429-1439. PubMed
- Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. J Dermatol.Sci 2007;48(2):141-144. PubMed
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