PhosphaLine Ingredients & Drug Interactions
by XYMOGEN
What is this page for?
First and foremost: checking PhosphaLine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PhosphaLine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PhosphaLine by XYMOGEN
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PhosphaLine has one active ingredient: polyenylphosphatidylcholine, a fat-soluble compound that's a building block of cell membranes. The softgel also contains glycerides, fatty acids, and ethanol as inactive ingredients to deliver it.
Does it work?
Moderate evidence
The evidence is mixed. Polyenylphosphatidylcholine is possibly effective for ulcerative colitis (inflammatory bowel disease).
For nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety, the evidence we hold is insufficient — we don't know yet whether it works for those uses.
How safe is it?
Well-documented data
Polyenylphosphatidylcholine is generally well tolerated when taken by mouth. At high doses (30 grams per day or more), it can cause digestive upset and diarrhea; even smaller doses have triggered bloating, diarrhea, altered taste, nausea, and vomiting in some people.
You may also notice increased sweating or itching. Choline (which your body gets from this ingredient) is needed in pregnancy, but supplement safety beyond food sources isn't well studied — talk with your doctor before taking it if you're pregnant.
There isn't enough data on supplement use while breastfeeding; check with your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient in this product. That said, run your exact medications through the search tool on this page before you start, and let your doctor or pharmacist know you're taking it.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
PhosphaLine may be worth considering if you have ulcerative colitis and want to explore a possibly effective option. If you're pregnant, breastfeeding, or taking any medications, talk it over with your doctor or pharmacist first — they know your full picture and can tell you whether this is right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PhosphaLine, straight from the product label.
| Brand | XYMOGEN |
|---|---|
| Barcode (UPC) | 871149001049 |
| Net contents | 300 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2017 |
| DSLD ID | 81428 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PhosphaLine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 Calorie(s) | -- |
| Total Fat | 3 Gram(s) | 4% |
| Polyenylphosphatidylcholine | 2.7 Gram(s) | -- |
Other ingredients: Glycerides and Fatty Acids, Softgel, Ethanol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Professional use only
Unlike most other phosphatidylcholine products on the markets, PhosphaLine contains no other phospholipids, aside from PPC and DLPC, that may compete for absorption. Studies suggest that PPC ingestion increases choline levels in the blood and brain and supports acetylcholine synthesis for healthy brain and liver function, healthy cholesterol levels already within the normal range, and gastric mucosal protection. PPC is widely used to support healthy aging.
ePV Exclusive professional formulas
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Brand IP Statement(s)
Not for resale on third-party websites, including, but not limited to, Amazon and eBay.
2016 XYMOGEN
Suggested/Recommended/Usage/Directions
Directions: Take two to three softgels daily, or as directed by your healthcare practitioner.
Precautions
Consult your healthcare practitioner prior to use.
Individuals taking medication should discuss potential interactions with their healthcare practitioner.
Do not use if tamper seal is damaged.
Storage: Keep tightly closed in a dry place at controlled room temperature 15(0)-30(0)C (59(0)-86(0)F), out of reach of children.
Contains: Soy.
Formula
PhosphaLine provides 2.7 g of pure polyenylphosphatidylcholine (PPC) per serving plus the highest concentrated source of 1,2 DLPC ( dilinoleoylphosphatidylcholine).
100% pure polyenylphosphatidylcholine concentrate
Contains: Soy.
Formulation
Unlike most other phosphatidylcholine products on the markets, PhosphaLine contains no other phospholipids, aside from PPC and DLPC, that may compete for absorption.
Does Not Contain: Wheat, gluten, yeast, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Storage: Keep tightly closed in a dry place at controlled room temperature 15(0)-30(0)C (59(0)-86(0)F), out of reach of children.
FDA Statement of Identity
Dietary Supplement
General
ZLB-PHOS300-01 REV. 080516
Seals/Symbols
Third-Party GMP Compliant Verified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PhosphaLine by XYMOGEN label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PhosphaLine by XYMOGEN
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container100 Amounts shown are per serving.
Polyenylphosphatidylcholine
No knowninteractions
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...
Polyenylphosphatidylcholine monograph & interactionsOther (inactive) ingredients: Glycerides and Fatty Acids, Softgel, Ethanol. These complete the product’s ingredient list but are not active constituents.
PhosphaLine by XYMOGEN Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PhosphaLine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PhosphaLine, from the product label.
XYMOGEN
See all XYMOGEN products- Name
- XYMOGEN Exclusive Professional Formulas
- Street Address
- 6900 Kingspointe Pkwy.
- City
- Orlando
- State
- FL
- ZipCode
- 32819
- Phone Number
- 800-647-6100
- Web Address
- www.xymogen.com
PhosphaLine by XYMOGEN: Common Questions
Does PhosphaLine by XYMOGEN interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is polyenylphosphatidylcholine and what does it do?
Will this help my liver?
What side effects should I watch for?
Is it safe to take if I'm pregnant?
Can I take this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PhosphaLine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PhosphaLine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PhosphaLine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phosphatidylcholine 15 references
- Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
- Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
- Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
- Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
- Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
- Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
- Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
- Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
- Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
- Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
- Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
- Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
- Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC