Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Premier ACV Ingredients & Drug Interactions

by Premier Research Labs

Premier ACV label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premier ACV against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premier ACV is a dietary supplement by Premier Research Labs with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Apple Cider Vinegar. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Premier ACV by Premier Research Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Premier ACV by Premier Research Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Premier ACV by Premier Research Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “ACV Complex” is a proprietary blend — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

Premier ACV contains 2 active ingredients: organic apple cider vinegar and organic rice extract, plus a blend called ACV Complex. The apple cider vinegar is the main player here—it's vinegar made from apples and is used in this form as a dietary supplement.

The rice extract and ACV Complex round out the formula, though we hold no interaction data for the rice extract to tell you how it works.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pH balance support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence on apple cider vinegar for the claims made on this product—acne, athletic performance, cognitive function, dental plaque, depression, and atopic dermatitis (eczema)—is insufficient to rate. That means the research so far hasn't been solid enough to confirm whether it works for any of these.

If you're taking this for one of those reasons, know that we don't have reliable data backing the benefit yet.

The evidence, ingredient by ingredient Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In food amounts—the kind you'd use in salad dressing—apple cider vinegar is generally well tolerated. Short-term use in medicinal doses also seems okay for most people.

The real concern comes with large doses or long-term use: rare cases have reported low potassium, high renin levels, and bone loss (osteoporosis) after years of heavy use. Topically (on the skin), apple cider vinegar can cause chemical burns and irritation, so avoid applying it directly to your skin.

There isn't enough safety data on large supplement amounts to know what's truly safe long-term. Do not use undiluted vinegar or large doses unless your doctor approves.

For pregnancy and breastfeeding, we hold no safety data for this product—talk with your doctor or pharmacist before taking it during these times.

Side effects, ingredient by ingredient Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Premier ACV, double-check with your doctor or pharmacist if you take digoxin (a heart drug)—there's a Moderate risk that apple cider vinegar will lower your potassium and increase heart toxicity. Also flag diuretics (water pills) and insulin if you use them; both carry Moderate-severity interactions tied to low potassium.

If you take diabetes drugs, note the Minor-severity risk of blood sugar dropping too low (hypoglycemia).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take heart medications (especially digoxin), diuretics (water pills), insulin, or diabetes drugs, you need to check this product with your doctor or pharmacist first—the apple cider vinegar content can affect how these work and raise the risk of low potassium. For others, apple cider vinegar in supplement form is generally tolerated short-term, but we don't have solid evidence it works for the claims made (acne, brain function, dental plaque, depression, or eczema).

Talk it over with your doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premier ACV, straight from the product label.

Brand Premier Research Labs
Barcode (UPC) 807735029401
Net contents 120 Plant-Source Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269201
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premier ACV by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
807735029401
IngredientAmount% DV
organic Rice extract0 NP--
organic Apple Cider Vinegar0 NP--
ACV Complex1500 mg--

Other ingredients: Plant-Source Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 4 capsules daily or as directed by a health professional.

Precautions

California Residents Only Prop 65 warning reproductive harm www.Prop65Warnings.ca.gov

Tamper seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant or nursing, taking medications or have a medical condition, before taking this or any other product.

Keep out of reach of children.

Formula

This vinegar is derived from the natural fermentation of premier quality, organic apples. Vinegar had been used worldwide for centuries for its culinary benefits. Today, vinegar has been recognized for its fermented enzymes and acidic properties. Vinegar possesses naturally occurring, microbial-created organic acids (malic acid, acetic acid, succinic acid, lactic acid) which have important biological functions.

Apple cider vinegar caps

Naturally contains organic acids; supports pH balance

OU (Kosher) We are proud to offer many OU Kosher Certified products.

Formulation

The natural acidic properties of apple cider vinegar help balance pH.

Live-source fermentation

PRL's quality guarantee Plant-based nutrients Potency verified Purity verified No radiation sterilization Pathogen tested by microbiology Heavy Metal tested FDA-monitored cGMP facility

Non-GMO No added magnesium stearate

PRL's quality program. Manufactured to avoid: added magnesium stearate (an undesirable excipient), artificial colors, artificial flavors or artificial preservatives.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Seals/Symbols

OU (Kosher) We are proud to offer many OU Kosher Certified products.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premier ACV by Premier Research Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premier ACV label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premier ACV by Premier Research Labs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ACV Complex

1500 mg per serving

Other (inactive) ingredients: Plant-Source Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premier ACV by Premier Research Labs Drug Interactions

Want to check YOUR meds against Premier ACV?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
89 Moderate 73 Minor

Ingredients driving the most interactions

organic Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in Premier ACV interact with 162 drugs. Click any drug to see the details.

1 of the 2 ingredients in Premier ACV interact with drugs. Each result below shows which ingredient is responsible. organic Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Premier ACV with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
organic Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premier ACV, from the product label.

Premier Research Labs

See all Premier Research Labs products
Name
Premier Research Labs
Pharmacist Counseling Corner

Premier ACV by Premier Research Labs: Common Questions

Does Premier ACV by Premier Research Labs interact with any medications?
Yes. Based on its ingredients, Premier ACV has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premier ACV contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does apple cider vinegar actually work for acne, brain fog, or skin conditions?
According to the data we hold, we don't have enough reliable evidence to rate apple cider vinegar for acne, cognitive function, dental plaque, eczema, depression, or athletic performance. The research hasn't been solid enough yet to say whether it works for these.
Is it safe to take apple cider vinegar supplements long-term?
In food amounts (like in dressing), it's fine. Short-term medicinal use is generally tolerated too. But long-term or large doses—especially supplement amounts—haven't been well studied. Rare cases have reported serious effects like low potassium and bone loss after years of heavy use, so avoid large doses and talk with your doctor before using this long-term.
Can I use apple cider vinegar on my skin?
Topical apple cider vinegar can cause chemical burns and skin irritation, especially if left on for days. Don't apply it directly to your skin—stick to taking it by mouth if you use it at all.
What if I take a water pill or heart medication—is this product okay for me?
Not without checking first. Apple cider vinegar may lower potassium levels, which is especially risky if you take digoxin (a heart drug), diuretics (water pills), or insulin. Talk with your doctor or pharmacist before starting this product to make sure it's safe with your medications.
Is it safe to take while pregnant or breastfeeding?
We don't have enough safety data to advise either way. Talk with your doctor or pharmacist before taking this during pregnancy or breastfeeding—they can give you personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premier ACV is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premier ACV label
Go deeper

The Full Monographs Behind Premier ACV’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Premier ACV's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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