Interactions on record — worth a quick check against your medications. Based on 8 of 17 ingredients. Check your meds →
Dietary supplement

PRO-15 Advanced Unflavored Ingredients & Drug Interactions

by Hyperbiotics

PRO-15 Advanced Unflavored label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PRO-15 Advanced Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PRO-15 Advanced Unflavored is a dietary supplement by Hyperbiotics with 17 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 503 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Actazin Kiwifruit Powder, Sodium, L. acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PRO-15 Advanced Unflavored by Hyperbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with PRO-15 Advanced Unflavored by Hyperbiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PRO-15 Advanced Unflavored by Hyperbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 17 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

PRO-15 Advanced Unflavored contains 17 ingredients, including sodium, 11 live probiotic strains (Lactobacillus acidophilus, L. casei, L. paracasei, L. plantarum, L. gasseri, L. rhamnosus, L. salivarius, L. reuteri, L. fermentum, and Bifidobacterium breve, B. longum, B. bifidum, B. longum infantis, B. animalis lactis), Streptococcus thermophilus, and Actazin Kiwifruit Powder. The inactive ingredients are microcrystalline cellulose, hydroxypropyl methylcellulose, pectin, sodium carbonate, stearic acid, and guar gum.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gut health and digestive balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Constipation, Colic, Dyspepsia, Abdominal pain — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for most conditions isn't established in our data. Sodium is likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity, though the evidence for bipolar disorder and congestive heart failure is insufficient.

Among the probiotics, L. acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis; B. bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. For most other uses listed—including asthma, allergic rhinitis, anxiety, and cognitive decline—the evidence is insufficient.

Kiwifruit powder's effectiveness for asthma, constipation, high blood pressure, or irritable bowel syndrome is not established in our data.

The evidence, ingredient by ingredient Sodium Lactobacillus Acidophilus Bifidobacterium Breve Bifidobacterium Longum Bifidobacterium Bifidum Lactobacillus Gasseri Streptococcus Thermophilus Kiwi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated in normal dietary amounts, but too much is linked to high blood pressure and heart strain. Serious adverse effects from oral sodium are rare but include worsened cardiovascular disease, hypertension, and kidney disease; avoid sodium supplements or very high intake without medical advice.

The probiotic strains are generally well tolerated in healthy adults and children, though rare cases of bacterial infection (bacteremia or sepsis) have been reported in critically ill or severely immunocompromised patients. Gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and diarrhea are uncommon but possible.

Kiwifruit can cause hypersensitivity reactions in some people—including mouth and throat swelling, rash, nausea, diarrhea, and in rare cases anaphylaxis or asthma exacerbation. For pregnancy and lactation: sodium is listed as likely safe but also possibly unsafe (conflicting data exist), so talk with your doctor.

L. acidophilus is possibly safe in pregnancy; L. longum and B. bifidum are possibly safe in pregnancy. Data on most other strains during pregnancy or breastfeeding aren't on file.

Kiwifruit is likely safe in pregnancy and lactation.

Side effects, ingredient by ingredient Sodium Lactobacillus Acidophilus Bifidobacterium Breve Bifidobacterium Longum Bifidobacterium Bifidum Lactobacillus Gasseri Streptococcus Thermophilus Kiwi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Lactobacillus Acidophilus, Kiwi, Sodium, Bifidobacterium Breve, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 503 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take lithium (sodium can alter its levels significantly), any blood pressure medication, blood thinners like warfarin or aspirin, antibiotics (timing the probiotic separately is key), corticosteroids, didanosine, sodium phosphates, tolvaptan, or any other sodium-containing drug. These are the drug types affected by ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-strain probiotic supplement with added sodium and kiwifruit—potentially helpful for certain digestive or probiotic-related concerns if you tolerate probiotics well. If you take lithium, blood pressure medications, blood thinners, antibiotics, corticosteroids, or any sodium-containing drug, check your exact medications with your doctor or pharmacist before starting, since the interactions here are real and sometimes serious.

If you're allergic to kiwi or have a weakened immune system, talk it over first. For everyone else, a conversation with your healthcare provider is a good idea to confirm it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PRO-15 Advanced Unflavored, straight from the product label.

Brand Hyperbiotics
Barcode (UPC) 9506000058542
Net contents 30 Time-Release Tablet(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306764
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PRO-15 Advanced Unflavored by Hyperbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
9506000058542
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Sodium10 mg1%
Added Sugars0 Gram(s)1%
Total Sugars0 Gram(s)--
Proprietary Probiotic Blend300 mg--
L. acidophilus0 NP--
L. casei0 NP--
L. paracasei0 NP--
B. breve0 NP--
B. longum0 NP--
B. bifidum0 NP--
B. longum infantis0 NP--
L. plantarum0 NP--
B. animalis lactis0 NP--
L. gasseri0 NP--
L. rhamnosus0 NP--
S. thermophilus0 NP--
L. salivarius0 NP--
L. reuteri0 NP--
Actazin Kiwifruit Powder250 mg--
L. fermentum0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Sodium Carbonate, Stearic Acid, Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information on gut health and to reorder, visit hyperbiotics.com

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 tablet per day with or without food.

Storage

No refrigeration necessary. Store in a cool, dry place.

Precautions

Keep out of reach of children.

Use only if safety seal is intact.

Formulation

Free of dairy, gluten, soy, peanut, tree nut, egg, fish, shellfish, active yeast, preservatives, artificial flavors and colors, and added sugar, and is non-GMO. Dairy free Gluten free

Additional support for gut comfort and health 15x more survivability BIO-tract vs. instant release formulations under in vitro test conditions.

Vegan

Brand IP Statement(s)

BIO-tract is a registered trademark of Probi USA, Inc. Actazin is a trademark of Anagenix Ltd.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

PRO-15 Advanced with Kiwifruit 15 billion CFU 15 strains

(15 Billion CFU) At the time of manufacture. Minimum of 5 Billion CFU at expiration. Pectin Adds a negligible amount of sugar.

FDA Statement of Identity

Premium Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PRO-15 Advanced Unflavored by Hyperbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PRO-15 Advanced Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PRO-15 Advanced Unflavored by Hyperbiotics

These are the 17 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Proprietary Probiotic Blend

300 mg per serving

Actazin Kiwifruit Powder

Interacts with
289 drugs
250 mg per serving

Kiwi is a nutritious fruit that is rich in vitamin C, fiber, and antioxidants, and it is generally safe to eat as a food. The strongest evidence is fo...

Actazin Kiwifruit Powder monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Sodium Carbonate, Stearic Acid, Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

PRO-15 Advanced Unflavored by Hyperbiotics Drug Interactions

Want to check YOUR meds against PRO-15 Advanced Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
503Drugs
503 Moderate

Ingredients driving the most interactions

Actazin Kiwifruit Powder 289
Sodium 205
L. acidophilus 182
B. breve 182
B. longum 182

Individual Drug Interactions

The ingredients in PRO-15 Advanced Unflavored interact with 503 drugs. Click any drug to see the details.

7 of the 17 ingredients in PRO-15 Advanced Unflavored interact with drugs. Each result below shows which ingredient is responsible. Actazin Kiwifruit Powder Sodium L. acidophilus B. breve B. longum B. bifidum L. gasseri

Each ingredient & the kinds of drugs it affects

For each ingredient in PRO-15 Advanced Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Actazin Kiwifruit Powder2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Clinical research suggests that kiwi inhibits platelet aggregation. Theoretically, kiwi might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals. Theoretically, concomitant use of kiwi and antihypertensive drugs may increase the risk of hypotension when used in combination with drugs that lower blood pressure. These include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Actazin Kiwifruit Powder full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions

B. breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
B. breve full monograph & interactions

B. longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. longum full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

L. gasseri1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
L. gasseri full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PRO-15 Advanced Unflavored, from the product label.

Hyperbiotics

See all Hyperbiotics products
Name
Hyperbiotics
Street Address
45 Kenneth Dooley Drive
City
Middletown
State
CT
ZipCode
06457
Web Address
hyperbiotics.com
Pharmacist Counseling Corner

PRO-15 Advanced Unflavored by Hyperbiotics: Common Questions

Does PRO-15 Advanced Unflavored by Hyperbiotics interact with any medications?
Yes. Based on its ingredients, PRO-15 Advanced Unflavored has a known interaction with 503 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PRO-15 Advanced Unflavored contains 17 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
Not at the same time. The live probiotic strains in this product—L. acidophilus, B. breve, B. longum, B. bifidum, and L. gasseri—can be killed by antibiotics, making them ineffective. Ask your pharmacist to help you space them apart, usually by a few hours.
What does the sodium in this do?
Sodium is an essential mineral for nerve and muscle function, but this product contains enough that you need to be aware of your total sodium intake, especially if you have high blood pressure, heart disease, or kidney issues. Talk to your doctor about whether the sodium amount is right for you.
I'm allergic to kiwi. Is this product safe for me?
No. This product contains Actazin Kiwifruit Powder. If you have a kiwi allergy—even a mild one—avoid this product, since allergic reactions can range from mouth swelling to anaphylaxis.
Will this help my IBS or diarrhea?
Some of the probiotic strains here—L. acidophilus and B. bifidum—are possibly effective for irritable bowel syndrome. For antibiotic-associated diarrhea and other digestive uses, the evidence is weaker or insufficient. Results vary by person; talk to your doctor about whether a probiotic trial makes sense for you.
Is this safe if I'm pregnant or breastfeeding?
Safety data vary by ingredient. Sodium is conflicting (likely safe but also listed as possibly unsafe), and most of the probiotic strains either lack data or are only possibly safe. Kiwifruit is likely safe. Because the picture is mixed, check with your doctor or midwife before starting.
Can I take this with my blood pressure medication?
Possibly, but not without checking first. Both the sodium and kiwifruit in this product can lower blood pressure, which combined with your medication might make it drop too much. Ask your doctor whether the combination is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PRO-15 Advanced Unflavored label
Go deeper

The Full Monographs Behind PRO-15 Advanced Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Kiwi

Interacts with 289 drugs

Kiwi is a nutritious fruit that is rich in vitamin C, fiber, and antioxidants, and it is generally safe to eat as a food. The strongest evidence is for helping with constipation and overall...

Read the full Kiwi monograph →
Sources

Sources & How We Checked

PRO-15 Advanced Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 155 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
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Lactobacillus Acidophilus 15 references
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Bifidobacterium Breve 9 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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Bifidobacterium Longum 21 references
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Bifidobacterium Bifidum 7 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

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Lactobacillus Gasseri 12 references
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Streptococcus Thermophilus 21 references
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Kiwi 32 references
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See these in context on the Kiwi monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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