Interactions on record — worth a quick check against your medications. Based on 6 of 11 ingredients. Check your meds →
Dietary supplement

PUMP Watermelon Lemonade Ingredients & Drug Interactions

by Core Nutritionals

PUMP Watermelon Lemonade label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PUMP Watermelon Lemonade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PUMP Watermelon Lemonade is a dietary supplement by Core Nutritionals with 11 active ingredients. Its ingredients are commonly taken for athletic performance and endurance, high-intensity exercise capacity, reducing muscle fatigue.Based on those ingredients, 524 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi, Hericium erinaceus, Cordyceps militaris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PUMP Watermelon Lemonade by Core Nutritionals

Ask about any prescription or over-the-counter medication and we check it for interactions with PUMP Watermelon Lemonade by Core Nutritionals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of PUMP Watermelon Lemonade by Core Nutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 11 active ingredients.
  • “PeakO2” is listed as a grouped ingredient — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

PUMP Watermelon Lemonade contains 11 ingredients. The active components are Beta-alanine (for athletic and physical performance), L-citrulline (an amino acid that widens blood vessels), Alpha-GPC (a choline compound), Hericium erinaceus (lion's mane mushroom), Reishi mushroom, Cordyceps militaris, and King Trumpet mushroom.

The product also includes Betaine Nitrate, PeakO2 (a blend of mushroom ingredients listed separately), and Hydromax (a glycerol supplement)—all meant to support workout performance and stamina. The rest are inactive ingredients like citric acid, malic acid, sweeteners, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pump, endurance, strength, and focus.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle breakdown, Muscle strength, Fatigue, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Beta-alanine is possibly effective for athletic and physical performance. L-citrulline is also possibly effective for athletic performance.

The other active ingredients—Alpha-GPC, lion's mane mushroom (Hericium erinaceus and King Trumpet), reishi, and cordyceps—don't have established effectiveness for athletic performance in our data; the evidence is rated insufficient to draw conclusions. Cordyceps is actually rated possibly ineffective for athletic performance.

The evidence, ingredient by ingredient Beta-alanine L-citrulline Alpha-gpc Lion's Mane Mushroom Reishi Mushroom Cordyceps

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in healthy adults short-term. Beta-alanine commonly causes harmless tingling and flushing on the skin, especially on the scalp—this typically starts within 20 minutes, spreads across the body, and lasts about an hour.

L-citrulline may cause gastrointestinal discomfort or heartburn. Lion's mane and reishi mushrooms may cause nausea and gastrointestinal discomfort.

Cordyceps can cause diarrhea, constipation, abdominal discomfort, or dry mouth. Beta-alanine, L-citrulline, alpha-GPC, lion's mane, reishi, and cordyceps all lack sufficient safety data in pregnancy and breastfeeding—the data advises against use in these situations unless your doctor directs otherwise.

Long-term safety for most of these ingredients is not well established.

Side effects, ingredient by ingredient Beta-alanine L-citrulline Alpha-gpc Lion's Mane Mushroom Reishi Mushroom Cordyceps

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Cordyceps, Reishi Mushroom, Alpha-gpc, L-citrulline, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 524 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications first if you take blood thinners or antiplatelet drugs (Moderate risk), blood pressure medications (Moderate), diabetes medication (Moderate), immune-suppressing drugs (Moderate), erectile dysfunction drugs like sildenafil or tadalafil (Moderate), or scopolamine motion sickness patches (Minor). No interactions are documented for beta-alanine specifically.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is formulated for workout performance, particularly athletic endurance. If you take blood pressure medication, blood thinners, diabetes medication, immune-suppressing drugs, or erectile dysfunction medication, check with your pharmacist first—the ingredients may interact.

It's well tolerated in healthy adults short-term, though you'll likely feel harmless tingling from the beta-alanine. Avoid during pregnancy and breastfeeding unless cleared by your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PUMP Watermelon Lemonade, straight from the product label.

Brand Core Nutritionals
Barcode (UPC) 672975315528
Net contents 16.2 Oz(s); 460 Gram(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 270093
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PUMP Watermelon Lemonade by Core Nutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
11.5 Gram(s)
Maximum serving Sizes:
23 Gram(s)
Servings per container
20
UPC/BARCODE
672975315528
IngredientAmount% DV
Beta Alanine3200 mg, 1600 mg--
L-Citrulline6000 mg, 3000 mg--
Alpha GPC600 mg, 300 mg--
Hericium erinaceus0 NP, 0 NP--
Betaine Nitrate2500 mg, 1250 mg--
PeakO22000 mg, 1000 mg--
Hydromax2000 mg, 1000 mg--
Reishi0 NP, 0 NP--
Turkey Tail0 NP, 0 NP--
Cordyceps militaris0 NP, 0 NP--
King Trumpet0 NP, 0 NP--
Shiitake0 NP, 0 NP--

Other ingredients: Silicon Dioxide, Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

It should be simple: the right combination of specifically targeted ingredients for pump, endurance, strength, and focus all blended together to produce a scientifically sound, and complete, non-stimulant pre-workout. It should be, but it isn't. It is a good thing for consumers, then, that Core Nutritionals loves a challenge. With Core PUMP, we redefine the non-stimulant, pre-workout category with more than just a "pump" product. Core PUMP contains cutting edge and trademarked ingredients to maximize all performance aspects of your workout, without stimulants or jitters.

Core PUMP contains cutting edge and trademarked ingredients to maximize all performance aspects of your workout, without stimulants or jitters.

Full-spectrum non-stimulant pre-workout Pump Endurance Strength Focus

Manufactured in a U.S. cGMP facility.

Precautions

Warning: This product is only intended for use in healthy adults 18 years of age or older.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor), PDE5 inhibitor, nitrates for chest pain, or any other medication.

Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Mix 2 scoops with 12-16 ounces of water and consume approximately 15-30 minutes prior to your workout.

Brand IP Statement(s)

Crush It!

NO3T Nitrate Technology NO3-T.COM/PATENTS NO3-T is a registered trademark of Thermolife International LLC, this mark covers the use of one or more patents listed at www.NO3-T.com/patents. HydroMax HydroMax is a registered trademark of Glanbia plc. PEAKO2 PeakO2 is a registered trademark of Compound Solutions, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Watermelon Lemonade Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PUMP Watermelon Lemonade by Core Nutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PUMP Watermelon Lemonade label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PUMP Watermelon Lemonade by Core Nutritionals

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size11.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta Alanine

No known
interactions
3200 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta Alanine monograph & interactions

L-Citrulline

Interacts with
178 drugs
6000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Alpha GPC

Interacts with
16 drugs
600 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions

Betaine Nitrate

2500 mg per serving

PeakO2

2000 mg per serving

Hydromax

2000 mg per serving Form: Glycerol, Powder

Other (inactive) ingredients: Silicon Dioxide, Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

PUMP Watermelon Lemonade by Core Nutritionals Drug Interactions

Want to check YOUR meds against PUMP Watermelon Lemonade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
524Drugs
500 Moderate 24 Minor

Ingredients driving the most interactions

Reishi 375
Hericium erinaceus 327
Cordyceps militaris 249
L-Citrulline 178
Alpha GPC 16

Individual Drug Interactions

The ingredients in PUMP Watermelon Lemonade interact with 524 drugs. Click any drug to see the details.

5 of the 11 ingredients in PUMP Watermelon Lemonade interact with drugs. Each result below shows which ingredient is responsible. Reishi Hericium erinaceus Cordyceps militaris L-Citrulline Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in PUMP Watermelon Lemonade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Hericium erinaceus3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Hericium erinaceus full monograph & interactions

Cordyceps militaris3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps militaris full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PUMP Watermelon Lemonade, from the product label.

Core Nutritionals

See all Core Nutritionals products
Name
Core Nutritionals, LLC
City
Sterling
State
Virginia
ZipCode
20164
Phone Number
(888) 978-2332
Web Address
www.CoreNutritionals.com
Pharmacist Counseling Corner

PUMP Watermelon Lemonade by Core Nutritionals: Common Questions

Does PUMP Watermelon Lemonade by Core Nutritionals interact with any medications?
Yes. Based on its ingredients, PUMP Watermelon Lemonade has a known interaction with 524 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PUMP Watermelon Lemonade contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will I feel any side effects from the beta-alanine in this product?
You'll likely feel tingling and flushing on your skin, especially on your scalp—it usually starts within 20 minutes and lasts about an hour. It's harmless. Intensity depends on the dose; smaller amounts produce milder tingling in only about a quarter of people. This is normal and expected.
Is this product safe during pregnancy?
No. Beta-alanine, L-citrulline, alpha-GPC, lion's mane, reishi, and cordyceps all lack enough safety information in pregnancy, so the data advises avoiding them unless your doctor says otherwise. Talk with your doctor or pharmacist before using this product if you're pregnant or planning to be.
Does this actually help with athletic performance?
Beta-alanine and L-citrulline are both rated possibly effective for athletic and physical performance in our data. The mushroom ingredients in this formula don't have established evidence for workout performance, and cordyceps is actually rated possibly ineffective. Results vary from person to person.
What does L-citrulline do?
L-citrulline is an amino acid your body converts to another amino acid called L-arginine, which widens blood vessels and improves blood flow. That's why it's added to pre-workout formulas—better blood flow may help oxygen and nutrients reach muscles during exercise.
Can I take this with my blood pressure medication?
Possibly not without checking first. L-citrulline and reishi mushroom may both lower blood pressure, so combining them with blood pressure medication could cause your pressure to drop too far. Talk to your pharmacist about your specific medication before starting.
Will this interact with blood thinners like warfarin or aspirin?
Yes, potentially. Lion's mane, reishi, and cordyceps may all increase bleeding risk when combined with blood thinners or antiplatelet drugs. Don't start this product if you take those medications without checking with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PUMP Watermelon Lemonade label
Go deeper

The Full Monographs Behind PUMP Watermelon Lemonade’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph →
Sources

Sources & How We Checked

PUMP Watermelon Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 62 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
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See these in context on the Alpha-gpc monograph →

Lion's Mane Mushroom 6 references
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See these in context on the Lion's Mane Mushroom monograph →

Reishi Mushroom 17 references
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See these in context on the Reishi Mushroom monograph →

Cordyceps 14 references
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See these in context on the Cordyceps monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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