PureProbiotic Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PureProbiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PureProbiotic is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against PureProbiotic by Pure Encapsulations
Ask about any prescription or over-the-counter medication and we check it for interactions with PureProbiotic by Pure Encapsulations — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of PureProbiotic by Pure Encapsulations
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
PureProbiotic contains six active probiotic ingredients: three Lactobacillus strains (rhamnosus, plantarum, and acidophilus) and three Bifidobacterium strains (bifidum, breve, and animalis lactis). These are live, beneficial bacteria meant to support digestive health.
The capsule itself is made from cellulose and water — no added fillers or binders.
Does it work?
Moderate evidence
The evidence for these probiotics is mixed and depends on what you're using them for. Lactobacillus acidophilus and Bifidobacterium bifidum are both possibly effective for irritable bowel syndrome (IBS) and for preventing diarrhea after antibiotics.
L. acidophilus is also possibly effective for bacterial vaginosis and H. pylori infection. B. breve doesn't have strong evidence for most uses we looked at — the data either aren't there yet or suggest it may not work.
Overall, the research on probiotics is still evolving, and results vary from person to person.
How safe is it?
Well-documented data
These probiotics are generally well tolerated in healthy adults and children. Mild gastrointestinal side effects like bloating, flatulence, and abdominal discomfort can happen, especially when you first start, but they're uncommon.
If you have a weakened immune system or are seriously ill, talk to your doctor before using this product — there are rare reports of these bacteria causing infection in critically ill patients, though it's very uncommon. For pregnancy, the limited data suggest these strains are possibly safe, but there isn't enough information on them during breastfeeding, so check with your doctor or pharmacist if you're nursing.
Meds to double-check
Moderate interaction found
If you take antibiotic drugs, don't take this probiotic at the same time — the antibiotics will kill the beneficial bacteria and make the supplement ineffective. Space your doses at least 2–3 hours apart, or ask your doctor or pharmacist for guidance on the best timing for your situation.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This probiotic blend is a good option if you're looking for support with IBS or antibiotic-related diarrhea, though results vary. The main thing to watch: don't take it at the same time as antibiotics — space them apart.
If you're immunocompromised, very ill, or pregnant or breastfeeding, talk it over with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PureProbiotic, straight from the product label.
| Brand | Pure Encapsulations |
|---|---|
| Barcode (UPC) | 766298013206 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 299736 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PureProbiotic by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lactobacillus rhamnosus LR-32 | 0 NP | -- |
| Lactobacillus plantarum LP-115 | 0 NP | -- |
| Lactobacillus acidophilus LA-14 | 0 NP | -- |
| Probiotic Blend | 0 NP | -- |
| Bifidobacterium bifidum Bb-06 | 0 NP | -- |
| Bifidobacterium breve Bb-18 | 0 NP | -- |
| Bifidobacterium animalis lactis Bb-04 | 0 NP | -- |
Other ingredients: Cellulose, Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Keep refrigerated
This formula requires refrigeration to maintain culture viability.
Suggested/Recommended/Usage/Directions
Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, with or between meals. Powder may be removed from capsule and mixed into cold food or beverage.
Precautions
Warning: Probiotics may be contraindicated for immunocompromised individuals.
If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
General Statements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements
Seals/Symbols
GFCO.org (Gluten-Free Certification Organization)
Formulation
Certified Gluten-Free by the Gluten-Free Certified Organization www.gluten.org Gluten-Free, Non-GMO & Hypoallergenic Allergen-free formula; Probiotic support for healthy intestinal microflora
Gluten-Free, Non-GMO & Hypoallergenic
Formula
Allergen-free formula; Probiotic support for healthy intestinal microflora
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PureProbiotic by Pure Encapsulations label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PureProbiotic by Pure Encapsulations
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Probiotic Blend
Interacts with182 drugs
Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...
Probiotic Blend monograph & interactions- › Lactobacillus rhamnosus LR-32
- › Lactobacillus plantarum LP-115
- › Lactobacillus acidophilus LA-14
- › Bifidobacterium bifidum Bb-06
- › Bifidobacterium breve Bb-18
- › Bifidobacterium animalis lactis Bb-04
Other (inactive) ingredients: Cellulose, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
PureProbiotic by Pure Encapsulations Drug Interactions
HelloPharmacist Interaction Report
PureProbiotic by Pure Encapsulations contains four live probiotic strains, three of which we have checked for interactions: Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium breve.
All three share the same concern with antibiotic drugs — antibiotics can kill the live organisms in the probiotic, making the supplement less effective. This is a moderate-severity interaction that's easy to manage by spacing out doses.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 182 individual medications. The affected drug type is antibiotics (a broad class that includes penicillins, fluoroquinolones, macrolides, and many others).
The fix is straightforward: take your antibiotic at least 2–3 hours apart from this probiotic, or ask your doctor or pharmacist for the best timing in your situation.
We couldn't check three of the six ingredients — Lactobacillus rhamnosus LR-32, Lactobacillus plantarum LP-115, and Bifidobacterium animalis lactis Bb-04 — because we hold no interaction data for them. That doesn't mean they're risk-free with medications, just that we haven't reviewed them.
Use the medication checker on this page to search your exact drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against PureProbiotic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in PureProbiotic interact with 182 drugs. Click any drug to see the details.
1 of the 1 ingredient in PureProbiotic interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend
Lefamulin AcetateXenleta
How Lefamulin Acetate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Lefamulin Acetate interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Lefamulin Acetate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Lefamulin Acetate interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Levofloxacin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Levofloxacin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Levofloxacin (ophthalmic) interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Levofloxacin (ophthalmic) interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Levofloxacin (ophthalmic) interactionLincomycin HclLincocin, Lincorex
How Lincomycin Hcl interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Lincomycin Hcl interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Lincomycin Hcl interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Lincomycin Hcl interactionLinezolidZyvox, Zyvox Injection
How Linezolid interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Linezolid interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Linezolid interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Linezolid interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Lomefloxacin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Lomefloxacin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Lomefloxacin interactionLoracarbefLorabid
How Loracarbef interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Loracarbef interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Loracarbef interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Loracarbef interactionMeropenemMerrem IV
How Meropenem interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Meropenem interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Meropenem interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Meropenem interactionMeropenem, VaborbactamVabomere
How Meropenem, Vaborbactam interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Meropenem, Vaborbactam interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Meropenem, Vaborbactam interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Meropenem, Vaborbactam interactionMethacyclineRondomycin
How Methacycline interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methacycline interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methacycline interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methacycline interactionMethenamine HippurateHiprex, Urex
How Methenamine Hippurate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine Hippurate interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine Hippurate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine Hippurate interactionMethenamine MandelateMandelamine, Methimazole
How Methenamine Mandelate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine Mandelate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine Mandelate interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine Mandelate interactionMethenamine Mandelate, Potassium Acid PhosphateThiacide
How Methenamine Mandelate, Potassium Acid Phosphate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine Mandelate, Potassium Acid Phosphate interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine Mandelate, Potassium Acid Phosphate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine Mandelate, Potassium Acid Phosphate interactionMethenamine Mandelate, Sodium Acid PhosphateUroquid-Acid No. 2
How Methenamine Mandelate, Sodium Acid Phosphate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine Mandelate, Sodium Acid Phosphate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine Mandelate, Sodium Acid Phosphate interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine Mandelate, Sodium Acid Phosphate interactionMethenamine, Phenyl Salicylate, Methylene BlueProsed DS
How Methenamine, Phenyl Salicylate, Methylene Blue interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine, Phenyl Salicylate, Methylene Blue interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine, Phenyl Salicylate, Methylene Blue interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine, Phenyl Salicylate, Methylene Blue interactionMethenamine, Sodium BiphosphateUro-Phosphate
How Methenamine, Sodium Biphosphate interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Methenamine, Sodium Biphosphate interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Methenamine, Sodium Biphosphate interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Methenamine, Sodium Biphosphate interactionMetronidazoleAnabact, Flagyl, Flagyl IV, Flagyl IV RTU, Likmez, Metro IV +12 more
How Metronidazole interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Metronidazole interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Metronidazole interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Metronidazole interactionMetronidazole, Tetracyline, Bismuth Subcitrate PotassiumPylera
How Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionMezlocillinMezlin
How Mezlocillin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Mezlocillin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Mezlocillin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Mezlocillin interactionMinocyclineAcnamino MR, Aknemin, Amzeeq, Arestin Miscrosperes, Dynacin, Minocin +6 more
How Minocycline interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Minocycline interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Minocycline interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Minocycline interactionMinocycline HydrochlorideMinolira, Ximino
How Minocycline Hydrochloride interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Minocycline Hydrochloride interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Minocycline Hydrochloride interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Minocycline Hydrochloride interactionMoxifloxacinAvelox
How Moxifloxacin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Moxifloxacin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Moxifloxacin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Moxifloxacin interactionNafcillinNallpen
How Nafcillin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Nafcillin interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Nafcillin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Nafcillin interactionNafcillin SodiumUnipen
How Nafcillin Sodium interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Nafcillin Sodium interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Nafcillin Sodium interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Nafcillin Sodium interactionNalidixic AcidNegGram
How Nalidixic Acid interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Nalidixic Acid interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Nalidixic Acid interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Nalidixic Acid interactionNeomycinMycifradin, Myciguent, Neo-Fradin
How Neomycin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Neomycin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Neomycin interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Neomycin interactionNetilmicinNetromycin
How Netilmicin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Netilmicin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Netilmicin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Netilmicin interactionNitrofurantoinFuradantin, Furatoin, Macrobid, Macrodantin
How Nitrofurantoin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Nitrofurantoin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Nitrofurantoin interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Nitrofurantoin interactionNorfloxacinNorflox, Noroxin
How Norfloxacin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Norfloxacin interactionBifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Norfloxacin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Norfloxacin interactionOfloxacinFloxin, Floxin Injection, Floxin Otic, Oflox
How Ofloxacin interacts with PureProbiotic — through 3 ingredients. Tap an ingredient for the detail:
Bifidobacterium Breve Bb-18Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve Bb-18 + Ofloxacin interactionBifidobacterium Bifidum Bb-06Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium.
Read the full Bifidobacterium Bifidum Bb-06 + Ofloxacin interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ofloxacin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in PureProbiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Probiotic Blend
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Brand information
Manufacturer and brand details for PureProbiotic, from the product label.
Pure Encapsulations
See all Pure Encapsulations products- Name
- Pure Encapsulations
- Street Address
- 490 Boston Post Road
- City
- Sudbury
- State
- MA
- Phone Number
- 1-800-753-2277
- Web Address
- www.PureEncapsulations.com
PureProbiotic by Pure Encapsulations: Common Questions
Does PureProbiotic by Pure Encapsulations interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while I'm on an antibiotic?
Will this help my IBS?
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Is it safe to take while I'm pregnant?
Does this have any fillers or binders?
Will this prevent diarrhea after I take antibiotics?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PureProbiotic is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PureProbiotic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBifidobacterium Bifidum
Interacts with 182 drugsBifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...
Read the full Bifidobacterium Bifidum monograph → Herb & supplement monographBifidobacterium Breve
Interacts with 182 drugsBifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...
Read the full Bifidobacterium Breve monograph →Sources & How We Checked
PureProbiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bifidobacterium Bifidum 7 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
See these in context on the Bifidobacterium Bifidum monograph →
Bifidobacterium Breve 9 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
- Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
- Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
- Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed
See these in context on the Bifidobacterium Breve monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC