Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Rejuvenate Ingredients & Drug Interactions

by Perricone MD Nutriceuticals

Rejuvenate label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rejuvenate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rejuvenate is a dietary supplement by Perricone MD Nutriceuticals with 5 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 995 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Alpha Lipoic Acid, Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Rejuvenate by Perricone MD Nutriceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Rejuvenate by Perricone MD Nutriceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Rejuvenate by Perricone MD Nutriceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Rejuvenate contains five active ingredients: alpha-lipoic acid, coenzyme Q10, vitamin E, L-carnitine L-tartrate, and tocotrienols complex. Alpha-lipoic acid is an antioxidant studied for blood sugar and cholesterol support.

Coenzyme Q10 supports cellular energy and heart health. Vitamin E is a fat-soluble antioxidant.

L-carnitine L-tartrate is an amino acid form involved in fat metabolism and energy production. Tocotrienols complex is a form of vitamin E with antioxidant properties.

The capsules also contain inactive ingredients including dicalcium phosphate, gelatin, cellulose, magnesium stearate, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support skin health and reduce visible aging signs.
  • We looked for evidence on: Aging skin, Acne, Atopic dermatitis (eczema), wrinkles, skin texture, photoaging.
  • The closest evidence on file: Vitamin E is rated "Possibly Ineffective" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin.
  • Also on file: Coenzyme Q10 is rated "Insufficient Reliable Evidence To Rate" for Aging.

Alpha-lipoic acid is possibly effective for diabetic nerve pain (neuropathy), high cholesterol (hyperlipidemia), and weight management (obesity). Coenzyme Q10 is likely effective for CoQ10 deficiency itself and possibly effective for fibromyalgia, migraines, heart failure, and diabetic neuropathy.

Vitamin E is effective for vitamin E deficiency and a rare genetic condition (ataxia with vitamin E deficiency), and possibly effective for Alzheimer's disease, beta-thalassemia, G6PD deficiency, and bleeding in the brain (intracranial hemorrhage). L-carnitine L-tartrate is effective for carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina.

Tocotrienols complex is possibly effective for diabetes but the evidence does not support use for high cholesterol; evidence is insufficient to rate its use for hair loss (alopecia areata) or breast cancer.

The evidence, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Vitamin E L-carnitine Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The product is generally well tolerated at typical doses. Common side effects from alpha-lipoic acid include headache, heartburn, nausea, and vomiting; from coenzyme Q10, gastrointestinal effects such as nausea and diarrhea (reported in less than 1% of users); from vitamin E, generally minimal but high doses raise bleeding risk; from L-carnitine L-tartrate, stomach upset and a fish-like body odor; and from tocotrienols, mild itching when applied topically.

Alpha-lipoic acid may lower blood sugar and is best used under medical guidance. Rare serious effects include insulin autoimmune syndrome (alpha-lipoic acid) and seizures (L-carnitine L-tartrate).

There is not enough reliable safety information to recommend this product during pregnancy, so it is best to avoid it unless your doctor advises otherwise. Vitamin E amounts from food and prenatal vitamins are appropriate, but high-dose supplements should only be used as directed by your doctor.

For breastfeeding, safety data is limited; check with your doctor before using, though normal dietary amounts of vitamin E are fine.

Side effects, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Vitamin E L-carnitine Tocotrienols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Alpha-lipoic Acid, Coenzyme Q10, Vitamin E, L-carnitine, Tocotrienols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 996 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk across multiple ingredients), thyroid hormone replacements (Moderate, from alpha-lipoic acid and L-carnitine L-tartrate), chemotherapy drugs including alkylating agents and antitumor antibiotics (Moderate, from alpha-lipoic acid and vitamin E), diabetes medications (Minor, from alpha-lipoic acid), or medications metabolized by CYP3A4 enzymes (Moderate, from vitamin E). The severity and individual risk depend on your specific drugs and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with diabetic nerve pain, cholesterol, heart health, and weight management, though evidence varies by ingredient. If you take blood thinners like warfarin, antiplatelet drugs, thyroid medication, diabetes drugs, or chemotherapy, you should not start this without clearing it first with your doctor or pharmacist — the ingredient interactions are real and dose matters.

Talk it over with your healthcare provider before adding it to your routine, especially if you take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rejuvenate, straight from the product label.

Brand Perricone MD Nutriceuticals
Net contents 60 Packet(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 209845
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rejuvenate by Perricone MD Nutriceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Alpha Lipoic Acid25 mg--
Coenzyme Q105 mg--
Vitamin E7.5 IU25%
L-Carnitine L-Tartrate75 mg--
Tocotrienols Complex5 mg--

Other ingredients: Dicalcium Phosphate, Gelatin, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplements

Formulation

Nourishes the body and the skin.

Product Benefits Targeted nutritional supplements are an essential part of Dr. Perricone's 3-Tier philosophy to healthy aging and beautiful skin. This daily program of nutrients is especially designed to support the health of skin. It also supports bone and joint function and healthy hair and nails.

Free of sugar, preservatives, yeast, artificial colors-flavors-dyes.

General Statements

Each packet contains: 3 softgels, 2 capsules and 3 caplets.

Clinical studies In a 8 week study, 86% reported improved skin texture. 78% reported healthier skin appearance. 65% reported lessening of crow's feet & lines and wrinkles.

Decades of research Perricone MD products are unique in that they are patented, researched and formulated by Nicholas Perricone, M.D., board certified dermatologist and anti-aging expert.

This carton is fully recyclable. It's manufactured using wind power and printed in a carbon neutral facility.

Made in USA.

C6 Carbon neutral

Suggested/Recommended/Usage/Directions

Directions Dr. Perricone recommends taking one packet twice daily with meals. A 30-day program.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: Before using any dietary supplement, pregnant or lactating women should consult with a physician or health professional.

Keep out of the reach of children.

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

Storage

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rejuvenate by Perricone MD Nutriceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rejuvenate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rejuvenate by Perricone MD Nutriceuticals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha Lipoic Acid

Interacts with
263 drugs
25 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Coenzyme Q10

Interacts with
198 drugs
5 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Vitamin E

Interacts with
764 drugs
7.5 IU per serving Form: D-Alpha-Tocopheryl Succinate, Mixed Tocopherols

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

L-Carnitine L-Tartrate

Interacts with
19 drugs
75 mg per serving

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine L-Tartrate monograph & interactions

Tocotrienols Complex

Interacts with
122 drugs
5 mg per serving

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Tocotrienols Complex monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Gelatin, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rejuvenate by Perricone MD Nutriceuticals Drug Interactions

Want to check YOUR meds against Rejuvenate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
995Drugs
776 Moderate 219 Minor

Ingredients driving the most interactions

Vitamin E 764
Alpha Lipoic Acid 263
Coenzyme Q10 198
Tocotrienols Complex 122
L-Carnitine L-Tartrate 19

Individual Drug Interactions

The ingredients in Rejuvenate interact with 995 drugs. Click any drug to see the details.

5 of the 5 ingredients in Rejuvenate interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Alpha Lipoic Acid Coenzyme Q10 Tocotrienols Complex L-Carnitine L-Tartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Rejuvenate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions

Tocotrienols Complex1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotrienols Complex full monograph & interactions

L-Carnitine L-Tartrate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine L-Tartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rejuvenate, from the product label.

Perricone MD Nutriceuticals

See all Perricone MD Nutriceuticals products
Name
NV Perricone LLC.
City
Meriden
State
CT
ZipCode
06450
Phone Number
1 888 823 7837
Pharmacist Counseling Corner

Rejuvenate by Perricone MD Nutriceuticals: Common Questions

Does Rejuvenate by Perricone MD Nutriceuticals interact with any medications?
Yes. Based on its ingredients, Rejuvenate has a known interaction with 995 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rejuvenate contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough reliable safety information to recommend this product during pregnancy, so the safety data advises against it. For breastfeeding, safety is not well studied — talk with your doctor or pharmacist before using. Normal dietary amounts of vitamin E are fine while breastfeeding.
What's alpha-lipoic acid supposed to do?
It's an antioxidant that shows promise for diabetic nerve pain, high cholesterol, and weight management, though the evidence is not definitive. It may also lower blood sugar, so it's best used under medical guidance.
Will this help my heart or cholesterol?
Coenzyme Q10 and L-carnitine L-tartrate are possibly effective for heart-related concerns like congestive heart failure and chest pain, and several ingredients may help cholesterol — but the strength of evidence varies. Talk with your doctor about whether this fits your specific situation.
What are the most common side effects?
Headache, nausea, heartburn, and stomach upset are the most commonly reported effects. A fish-like body odor has been reported with L-carnitine L-tartrate. Most people tolerate it well at typical doses.
Is this safe to take every day long-term?
Vitamin E at high doses raises the risk of bleeding over time. Tocotrienols long-term safety at supplement doses is not well established. Starting low and checking with your doctor or pharmacist about duration and dose is wise.
What's coenzyme Q10 for?
CoQ10 supports cellular energy production and is likely effective if you have a CoQ10 deficiency. It's possibly effective for fibromyalgia, migraines, heart failure, and diabetic nerve pain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rejuvenate label
Go deeper

The Full Monographs Behind Rejuvenate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Rejuvenate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 197 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
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L-carnitine 41 references
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Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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