Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Replenish The Root Teapills Ingredients & Drug Interactions

by Plum Flower

Replenish The Root Teapills label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Replenish The Root Teapills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Replenish The Root Teapills is a dietary supplement by Plum Flower with 5 active ingredients. Its ingredients are commonly taken for fatigue and low energy, digestive support and poor appetite, immune support.Based on those ingredients, 386 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rehmannia glutinosa extract, Codonopsis pilosula extract, Asparagus cochinchinensis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Replenish The Root Teapills by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Replenish The Root Teapills by Plum Flower — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Replenish The Root Teapills by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,360 mg) without saying how much of each component you get.

Replenish The Root Teapills contains 5 active ingredients, most of them herbal extracts. The main components are codonopsis root, rehmannia root (which appears twice in the formula), ophiopogon, and asparagus root — all traditional ingredients used in Chinese herbal medicine.

The product also contains inactive ingredients like microcrystalline cellulose and magnesium silicate as binders and fillers to hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chronic kidney disease (CKD) — rated "Possibly Effective" (Rehmannia) (Natural Medicines).

The evidence for what this formula does is limited. Rehmannia root is rated possibly effective for chronic kidney disease, but the rest of the ingredients lack reliable evidence — the facts show insufficient data for codonopsis (asthma, cancer, respiratory infections, and digestive issues), for asparagus root (acne, cancer, constipation, blood pressure, parasites, and kidney stones), and similar gaps for the others.

We hold no effectiveness data for ophiopogon. If you're considering this for a specific condition, talk with your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Codonopsis Rehmannia Asparagus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Codonopsis is generally well tolerated at traditional food-like doses, but high-quality safety studies are scarce. Very large doses (30–60 grams) may cause chest pain, arrhythmia, throat pain, or voice loss — and allergic reactions including anaphylaxis and hives are documented, though rare.

Rehmannia is traditionally used but has limited human safety data and quality varies between products. Asparagus root extract, while asparagus as food is safe, hasn't been proven safe at medicinal doses; allergic reactions can occur in people sensitive to the onion and garlic family, and one study of a combination product reported constipation, nausea, and gout-like symptoms in some users.

We hold no adverse effect data for ophiopogon. Because there isn't enough information to know if this product is safe during pregnancy or breastfeeding, it's best avoided unless your doctor advises otherwise.

Side effects, ingredient by ingredient Codonopsis Rehmannia Asparagus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Asparagus, Codonopsis, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 386 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (codonopsis may increase bleeding risk), diabetes medications (codonopsis and rehmannia may lower blood sugar further), blood pressure drugs (rehmannia may drop pressure more), diuretics or water pills (asparagus root may boost fluid loss), or lithium (asparagus root may raise lithium levels). Abiraterone users should also confirm — codonopsis may reduce how well it works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This teapill blend is rooted in traditional Chinese medicine, but the evidence for what it actually does is thin, and it carries moderate interaction risks with blood thinners, diabetes medications, blood pressure drugs, diuretics, and lithium. If you take any of those or other regular medications, check them against this product with your doctor or pharmacist before you start.

Pregnant or breastfeeding — skip it unless your healthcare provider gives you the go-ahead.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Replenish The Root Teapills, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934837153
Net contents 200 Pill(s); 1.2 Ounce(s); 34 Gram(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 230041
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Replenish The Root Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Pill(s)
Maximum serving Sizes:
8 Pill(s)
Servings per container
25
UPC/BARCODE
739934837153
IngredientAmount% DV
Proprietary Extract Blend1360 mg--
Codonopsis pilosula extract0 NP--
Rehmannia glutinosa extract0 NP--
Rehmannia glutinosa extract0 NP--
Ophiopogon japonicus extract0 NP--
Asparagus cochinchinensis extract0 NP--

Other ingredients: Microcrystalline Cellulose, hydrated Magnesium Silicate, Dextrin, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 8 pills 3 times daily or as directed by your health care practitioner

Precautions

Keep out of reach of children

General Statements

US owned & operated since 1969. Made in China in partnership with the award winning Lanzhou Foci Pharmaceutical Co. Ltd.

Gu Ben Wan

Seals/Symbols

Foci Pharmaceutical 1929

Formulation

Plum Flower Quality Guarantee

No pharmaceuticals or dyes, unsulfured, preservative-free herbs when available

Scientifically authenticated herbs Microbial and heavy metal tested Produced at an internationally certified (GMP) factory

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Replenish The Root Teapills by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Replenish The Root Teapills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Replenish The Root Teapills by Plum Flower

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1360 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydrated Magnesium Silicate, Dextrin, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Replenish The Root Teapills by Plum Flower Drug Interactions

Want to check YOUR meds against Replenish The Root Teapills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
386Drugs
386 Moderate

Ingredients driving the most interactions

Rehmannia glutinosa extract 258
Codonopsis pilosula extract 211
Asparagus cochinchinensis extract 76

Individual Drug Interactions

The ingredients in Replenish The Root Teapills interact with 386 drugs. Click any drug to see the details.

3 of the 5 ingredients in Replenish The Root Teapills interact with drugs. Each result below shows which ingredient is responsible. Rehmannia glutinosa extract Codonopsis pilosula extract Asparagus cochinchinensis extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Replenish The Root Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rehmannia glutinosa extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia glutinosa extract full monograph & interactions

Codonopsis pilosula extract3 drug types · 211 drugs

Abiraterone (Zytiga)

Theoretically, taking codonopsis root with abiraterone might reduce the levels and therapeutic effects of abiraterone.
Animal research in rats shows that intragastric administration of codonopsis root along with abiraterone every 2 days for 2 weeks seems to increase the clearance of abiraterone and reduce the overall exposure and time to maximum concentration. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, codonopsis liquor might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
A small clinical study in adults with coronary heart disease shows that consuming Codonopsis pilosula liquor for 4 weeks inhibits platelet aggregation but does not affect tissue-type plasminogen activator (t-PA) or plasminogen activator inhibitor (PAI).

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Laboratory and animal research suggest that codonopsis has antidiabetic effects.

Likelihood Possible Evidence D
Codonopsis pilosula extract full monograph & interactions

Asparagus cochinchinensis extract2 drug types · 76 drugs

Diuretic Drugs

Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus root extracts have diuretic effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, asparagus root might cause diuresis, reducing lithium clearance.
Animal studies show that asparagus root extracts have diuretic effects. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Asparagus cochinchinensis extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Replenish The Root Teapills, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
www.plumflowerherbs.com
Pharmacist Counseling Corner

Replenish The Root Teapills by Plum Flower: Common Questions

Does Replenish The Root Teapills by Plum Flower interact with any medications?
Yes. Based on its ingredients, Replenish The Root Teapills has a known interaction with 386 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Replenish The Root Teapills contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
Not without checking first. Codonopsis in this blend may theoretically increase your bleeding risk when combined with anticoagulants or antiplatelet drugs like warfarin or aspirin. A small study showed it can slow platelet clumping. Talk to your doctor or pharmacist — they may need to adjust your dose or monitor you more closely.
Is this safe during pregnancy or while breastfeeding?
The facts show there isn't enough safety information for codonopsis or rehmannia in pregnancy or lactation, so they're best avoided unless your doctor advises otherwise. Asparagus root is rated possibly unsafe in pregnancy and there's no clear data for breastfeeding either. Talk with your doctor or pharmacist for personalized advice before taking it.
Does this actually work for what it claims?
The evidence is limited. Rehmannia root is rated possibly effective for chronic kidney disease, but for most of the other ingredients — codonopsis for asthma, cancer, respiratory issues, or digestion; asparagus root for acne, constipation, or blood pressure — the data we hold shows insufficient evidence. Your doctor or pharmacist can discuss whether it's worth trying for your situation.
Are there any side effects I should watch for?
Allergic reactions, including anaphylaxis and hives, have been reported with codonopsis, though they're rare. Very large doses may cause chest pain, heart rhythm changes, throat pain, or voice loss. One study of an asparagus combination product reported constipation, nausea, and gallbladder complaints in up to half the participants. If you develop any unusual symptoms, stop and contact your doctor or pharmacist.
What do codonopsis and rehmannia do in this formula?
Both are traditional Chinese herbs used to support overall wellness, though the specific effects aren't yet well proven in clinical trials. Codonopsis is thought to support respiratory and digestive function, while rehmannia is traditionally used for kidney and blood health. Talk with your healthcare provider about whether either suits your health goals.
What's the difference between this and plain asparagus?
Asparagus the vegetable is generally safe to eat. This product contains a concentrated extract of asparagus root at medicinal doses, which hasn't been proven as safe and may carry higher risks — including diuretic effects and potential allergic reactions in sensitive people. It's a different level of exposure, which is why caution is advised.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Replenish The Root Teapills is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Replenish The Root Teapills label
Go deeper

The Full Monographs Behind Replenish The Root Teapills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Codonopsis

Interacts with 211 drugs

Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently as a milder substitute for ginseng. Human researc...

Read the full Codonopsis monograph → Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Asparagus

Interacts with 76 drugs

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a diuretic or for urinary health, come fr...

Read the full Asparagus monograph →
Sources

Sources & How We Checked

Replenish The Root Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Codonopsis 5 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Xu, X., Wang, S. R., and Lin, Q. [Clinical and experimental study on codonopsis pilosula oral liquor in treating coronary heart disease with blood stasis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(7):398-400.
  3. Hur GY, Choi GS, Park HJ, Ye YM, Park HS. Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis. Allergy. 2008;63(10):1406-7.
  4. Zhang ZB, Ip SP, Cho WCS, et al. Herb-drug interactions between androgenic Chinese herbal medicines and androgen receptor antagonist on tumor growth: Studies on two xenograft prostate cancer animal models. Phytother Res. 2021.
  5. Jia W, Bi Q, Jiang S, et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS. Food Funct 2022;13(5):2456-2464.

See these in context on the Codonopsis monograph →

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Asparagus 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Volz T, Berner D, Weigert C, et al. Fixed food eruption caused by asparagus. J Allergy Clin Immunol 2005;116:1390-2. PubMed
  4. Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids 2006;71:171-6. PubMed
  5. Rodriguez R, Jaramillo S, Rodriguez G, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem 2005;53:5212-7. PubMed
  6. Rieker J, Ruzicka T, Neumann NJ, Homey B. Protein contact dermatitis to asparagus. J Allergy Clin Immunol 2004;113:354-5. PubMed
  7. Tabar AI, Alvarez-Puebla MJ, Gomez B, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy 2004;34:131-6. PubMed
  8. Rademaker M, Yung A. Contact dermatitis to Asparagus officinalis. Australas J Dermatol 2000;41:262-3.
  9. Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G., Gil, R. R., and Burton, G. Withanolides and related steroids. Prog.Chem.Org.Nat.Prod. 2011;94:127-229.
  10. Hausen BM, Wolf C. 1,2,3-Trithiane-5-carboxylic acid, a first contact allergen from Asparagus officinalis (Liliaceae). Am J Contact Dermat 1996;7(1):41-46. PubMed
  11. Escribano MM, Munoz-Bellido FJ, Serrano P, et al. Acute urticaria after ingestion of asparagus. Allergy 1998;53(6):622-623. PubMed
  12. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
  13. Gaus BM, Scheiba N, Schäkel K. Asparagus-induced fixed food eruptions mimicking cutaneous lupus. Acta Derm Venereol 2014;94:731-2. PubMed
  14. Yanagi T, Shimizu H, Shimizu T. Occupational contact dermatitis caused by asparagus. Contact Dermatitis 2010;63:54. PubMed

See these in context on the Asparagus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team