Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

S-Acetyl L-Glutathione Plus Ingredients & Drug Interactions

by Adaptogen Research

S-Acetyl L-Glutathione Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking S-Acetyl L-Glutathione Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

S-Acetyl L-Glutathione Plus is a dietary supplement by Adaptogen Research with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 331 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl-Cysteine, Vitamin B-6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against S-Acetyl L-Glutathione Plus by Adaptogen Research

Ask about any prescription or over-the-counter medication and we check it for interactions with S-Acetyl L-Glutathione Plus by Adaptogen Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of S-Acetyl L-Glutathione Plus by Adaptogen Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

S-Acetyl L-Glutathione Plus contains 3 active ingredients. Vitamin B-6 is a B vitamin your body uses to make proteins and support nerve and immune function.

N-Acetyl-Cysteine (NAC) is an amino acid that helps your body produce glutathione, a natural antioxidant. S-Acetyl Glutathione is a stable form of glutathione, an antioxidant made by your cells.

The capsule also contains microcrystalline cellulose, vegetable stearate, and silicon dioxide as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports natural antioxidant activity.
  • We looked for evidence on: Acetaminophen poisoning, Acne, Acute respiratory distress syndrome (ARDS), Age-related cognitive decline, Age-related macular degeneration (AMD), Aging — and 4 related terms.
  • The strongest evidence on file: N-acetyl Cysteine (nac) is rated "Effective" for Acetaminophen poisoning (Natural Medicines).
  • Also on file: Vitamin B6 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Acne, Age-related macular degeneration (AMD).

The evidence we have on file covers vitamin B-6 and NAC only. Vitamin B-6 is Effective for sideroblastic anemia and B-6 deficiency, Likely Effective for lowering homocysteine, and Possibly Effective for pregnancy-related nausea.

NAC is Effective for acetaminophen poisoning and certain lung and airway conditions, and Possibly Effective for bronchitis. We hold no effectiveness data for S-Acetyl Glutathione.

The evidence, ingredient by ingredient Vitamin B6 N-acetyl Cysteine (nac)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B-6 is generally well tolerated at normal doses, but high doses over time can damage nerves (a condition called sensory neuropathy). Doses over 1,000 mg daily carry the most risk, though nerve damage can happen at lower amounts with extended use.

Common side effects at typical doses are uncommon but may include headache, nausea, and abdominal pain. NAC is generally well tolerated at standard doses.

At very high doses (more than 9 grams in a single dose or more than 30 grams daily), it can cause nausea, vomiting, heartburn, and diarrhea. Intravenous NAC can cause skin rash and allergic reactions.

During pregnancy, vitamin B-6 is Likely Safe at recommended levels, though it's often used for morning sickness only under a doctor's guidance. NAC is Possibly Safe in pregnancy, but the safety data isn't well established — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Vitamin B6 N-acetyl Cysteine (nac)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B6, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 331 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check with your pharmacist if you use any of the following: nitroglycerin (patch or IV — this is the most serious concern), blood thinners or antiplatelet drugs, blood pressure medications, seizure drugs like phenobarbital or phenytoin, the heart drug amiodarone, levodopa for Parkinson's, the antimalarial chloroquine, or activated charcoal. No interactions are documented for S-Acetyl Glutathione, but we hold no data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is worth considering if you're interested in antioxidant support and don't take nitroglycerin, blood thinners, seizure medications, or certain blood pressure drugs. If you're on any prescription medication — especially for the heart, blood pressure, or seizures — check with your pharmacist first.

Pregnant or breastfeeding? Talk to your doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about S-Acetyl L-Glutathione Plus, straight from the product label.

Brand Adaptogen Research
Barcode (UPC) 0612524953450
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247259
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for S-Acetyl L-Glutathione Plus by Adaptogen Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
0612524953450
IngredientAmount% DV
Vitamin B-610 mg500%
N-Acetyl-Cysteine1 Gram(s)--
S-Acetyl Glutathione200 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Notice: Color, size or shape may appear different between lots.

Made with Non-GMO ingredients Does not contain gluten

Vegetarian formula

Supports Natural Antioxidant Activity

S-A-GSH is well-suited for oral ingestion, because this acetyl group protects glutathione from breaking down in the gastrointestinal tract; once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Professional Use Only

Seals/Symbols

Guaranteed GMP Compliant Products

Precautions

Report any adverse reactions to 302-213-0030

Storage

Store at room temperature.

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take two capsules per day, or as directed by your health care practitioner.

Formula

Acetylated form of glutathione for optimum absorption and bioavailability. S-Acetyl Glutathione (S-A-GSH) is a unique form of glutathione, one of the most powerful antioxidants naturally produced in the body. It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule.

This product also includes N-acetyl-cysteine (NAC) and vitamin B6, both of which are important for the production of glutathione.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

S-Acetyl L-Glutathione Plus by Adaptogen Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

S-Acetyl L-Glutathione Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in S-Acetyl L-Glutathione Plus by Adaptogen Research

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B-6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B-6 monograph & interactions

N-Acetyl-Cysteine

Interacts with
294 drugs
1 Gram(s) per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-Cysteine monograph & interactions

S-Acetyl Glutathione

200 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

S-Acetyl L-Glutathione Plus by Adaptogen Research Drug Interactions

Want to check YOUR meds against S-Acetyl L-Glutathione Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
331Drugs
1 Major 325 Moderate 5 Minor

Ingredients driving the most interactions

N-Acetyl-Cysteine 294
Vitamin B-6 210

Individual Drug Interactions

The ingredients in S-Acetyl L-Glutathione Plus interact with 331 drugs. Click any drug to see the details.

2 of the 3 ingredients in S-Acetyl L-Glutathione Plus interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl-Cysteine Vitamin B-6

Each ingredient & the kinds of drugs it affects

For each ingredient in S-Acetyl L-Glutathione Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-Cysteine full monograph & interactions

Vitamin B-65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B-6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for S-Acetyl L-Glutathione Plus, from the product label.

Adaptogen Research

See all Adaptogen Research products
Name
Adaptogen Research
Street Address
625 Barksdale Road, Suite 113
City
Newark
State
DE
ZipCode
19711
Phone Number
302-213-0030
Pharmacist Counseling Corner

S-Acetyl L-Glutathione Plus by Adaptogen Research: Common Questions

Does S-Acetyl L-Glutathione Plus by Adaptogen Research interact with any medications?
Yes. Based on its ingredients, S-Acetyl L-Glutathione Plus has a known interaction with 331 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
S-Acetyl L-Glutathione Plus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy?
Vitamin B-6 in this product is Likely Safe at recommended levels during pregnancy, though it's often used for morning sickness only under a doctor's guidance. NAC is Possibly Safe in pregnancy, but the safety data isn't well studied. Talk with your doctor or pharmacist before starting — they can give you personalized advice based on your situation.
Can high doses of B-6 in this product cause nerve damage?
Yes, but only at very high doses. High doses of vitamin B-6 over time can cause sensory neuropathy — nerve damage that causes tingling or weakness. The biggest risk is with doses over 1,000 mg daily, though it can happen at lower amounts with long-term use. A typical supplement dose is much lower, so that's less of a concern — just don't exceed the label dose without a doctor's reason.
What does N-Acetyl-Cysteine do?
NAC is an amino acid your body uses to make glutathione, an antioxidant that helps protect your cells. It's Effective for treating acetaminophen overdose and is used in some lung and airway conditions, and it's Possibly Effective for bronchitis. In this product, it's included to help boost your body's own glutathione levels.
Is this safe if I take blood pressure medication?
Possibly, but you need to check with your pharmacist first. Both vitamin B-6 and NAC may add to the blood pressure-lowering effect of your medication, which could lower your blood pressure too much. Your pharmacist can review your specific drug and dose to let you know if it's okay to take together.
What are the most common side effects?
At typical doses, both vitamin B-6 and NAC are generally well tolerated. The most common side effects are mild — nausea, diarrhea, heartburn, dry mouth, headache, and loss of appetite. These are uncommon at standard doses and usually go away quickly.
Can I take this with activated charcoal?
Not recommended. NAC may reduce how well activated charcoal works, and activated charcoal may reduce how much NAC your body absorbs. If you use activated charcoal for any reason, talk to your pharmacist about timing or whether to skip this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

S-Acetyl L-Glutathione Plus label
Go deeper

The Full Monographs Behind S-Acetyl L-Glutathione Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph →
Sources

Sources & How We Checked

S-Acetyl L-Glutathione Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 118 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

N-acetyl Cysteine (nac) 86 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7. PubMed
  3. van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung C DOI
  4. Horowitz RS, Dart RC, Jarvie DR, et al. Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997;35:447-51.
  5. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-5. PubMed
  6. Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994;23:519-23. PubMed
  7. Ardissino D, Merlini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol 1997;29:941-7. PubMed
  8. Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. Eur Heart J 1988;9:95-100. PubMed
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