Shilajit Supreme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Shilajit Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Shilajit Supreme is a dietary supplement by HealthForce SuperFoods with 2 active ingredients. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 166 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shilajit, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Shilajit Supreme by HealthForce SuperFoods
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Shilajit Supreme by HealthForce SuperFoods
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Shilajit Supreme contains 2 active ingredients: iron and shilajit. Iron is a mineral your body uses to make hemoglobin, the protein in red blood cells that carries oxygen.
Shilajit is a plant-derived substance that has been used in traditional medicine, though the evidence for its modern uses is limited. The product contains no inactive ingredients listed.
Does it work?
Moderate evidence
Iron is well established as effective for iron deficiency anemia, anemia of chronic disease, and iron deficiency in pregnancy. It's also possibly effective for heart failure, though the evidence is weaker there.
Shilajit, on the other hand, has insufficient reliable evidence to rate its effectiveness for the conditions it's marketed for — including Alzheimer's disease, sexual dysfunction, athletic performance, benign prostatic hyperplasia, and osteoporosis. The evidence we hold doesn't support claims for any of those uses.
How safe is it?
Well-documented data
Iron is generally well tolerated at recommended doses, but excess iron can be toxic and should only be used when there's a real need. The most common side effects are gastrointestinal — abdominal pain, constipation, diarrhea, nausea, and vomiting.
Rare serious effects include gastric ulcerations. Iron is often used in pregnancy under your prenatal care provider's guidance, and it's generally considered acceptable while breastfeeding at appropriate doses, though you should confirm with your provider.
Shilajit carries more caution. Unpurified products may contain heavy metals or other contaminants, so only use purified, tested brands.
The safety data advises against shilajit in pregnancy and breastfeeding. Reported adverse effects are rare but include a case of severe allergic reaction (anaphylaxis) and a case of high blood pressure with mineral imbalances, though shilajit's exact role couldn't be confirmed in that case.
Meds to double-check
Moderate interaction found
Before you take this, check with your doctor or pharmacist if you're on levodopa (for Parkinson's), quinolone or tetracycline antibiotics, bisphosphonates, methyldopa, levothyroxine, mycophenolate mofetil, or penicillamine — iron can significantly reduce how much your body absorbs these drugs. Also check if you take any antidiabetes medication; shilajit may lower blood sugar further and raise the risk of low blood sugar.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is most appropriate if you need iron for genuine iron deficiency or chronic anemia, and you don't take levodopa, antibiotics, thyroid medication, or other drugs that iron interferes with. If you take any regular medication, especially antidiabetes drugs, check your exact prescriptions against the interaction checker on this page before you start.
Talk with your doctor or pharmacist about whether you actually need supplemental iron and whether this product is right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Shilajit Supreme, straight from the product label.
| Brand | HealthForce SuperFoods |
|---|---|
| Barcode (UPC) | 650786003278 |
| Net contents | 50 Gram(s); 3.53 Oz(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2017 |
| DSLD ID | 75639 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Shilajit Supreme by HealthForce SuperFoods, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Iron | 1 mg | 5% |
| Shilajit | 0.4 Gram(s) | -- |
| Ingredient: | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Shilajit is a potent adaptogen composed of compressed humus and organic plant material. Five-thousand year old Ayurvedic texts discuss uses for this very special compound, and many herbalists consider shilajit to be the most important tonic substance in traditional Ayurveda. Shilajit consumption supports: Endocrine function Energy metabolism Brain function Detoxification Immune function Better nutrient absorption
“Hype is Nothing. Substance is Everything !” Dr. Jameth Sheridan – Naturopath and Hard-Core Herbal Medicine Researcher
100% post-consumer recycled paper (dioxin free) produced with wind energy.
High mountain shilajit
cold water extracted
Supports endocrine function, energy, metabolism, brain function, detoxification, immune function
Product of India
Brand IP Statement(s)
Shilajit Supreme is gathered from a pristine high mountain region of the Himilayan Mountains of India and concentrated via a unique, full-spectrum, cold water extraction and filtration process (below 100(0)F) into a nutrient-rich powder that is abundant in dibenzo-alpha-pyrones, plant-based trace minerals, unique phytochemicals and amino acids, antioxidants, and naturally high concentrations of fulvic acid (over 50%). Shilajit Supreme is tested for identity, pesticides, irradiation, GMOs, solvent residues, heavy metals, and fulvic acid content to assure the highest level of purity and potency.
FDA Disclaimer Statement
The statements have not been evaluated by the Food and Drug Administration. This product is not designed to diagnose, treat, cure, or prevent any disease.
General
Version 2 SHIL50|17042101
Formula
50% fulvic acid
OU Parve
Formulation
Gluten free
Certified vegan vegan.org
TruGanic verified
TruGanic: Actual testing (which no other standard requires) to verify non-GMO status and 100% free from pesticides and irradiation.
Seals/Symbols
Certified vegan vegan.org
TruGanic verified
OU Parve
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1/4 teaspoon daily with purified water, juice, smoothies, etc.
Suggested Adjuncts: A whole foods, organic, vegan diet with emphasis on fresh, highwater- content, uncooked/raw foods and juices, MacaForce, MycoForce Immunity, Vitamineral Green, Vitamineral Earth, exercise, a positive attitude, and fresh air.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Shilajit Supreme by HealthForce SuperFoods label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Shilajit Supreme by HealthForce SuperFoods
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.4 Gram(s) Dosage formPowder Servings per container125 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Iron
Interacts with80 drugs
Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...
Iron monograph & interactionsIngredient:
- › Shilajit
Shilajit Supreme by HealthForce SuperFoods Drug Interactions
HelloPharmacist Interaction Report
Shilajit Supreme by HealthForce SuperFoods contains iron and shilajit, both of which interact with medications.
Iron is the most serious concern here — it moderately interacts with levodopa (a Parkinson's drug), reducing how much your body absorbs, which could make it less effective. Iron also has moderate interactions with quinolone and tetracycline antibiotics, bisphosphonates (bone drugs), methyldopa (a blood pressure medication), levothyroxine (thyroid hormone), mycophenolate mofetil (an immunosuppressant), and penicillamine (a chelating agent for Wilson's disease) — all by the same mechanism: it forms complexes in your stomach and gut that block their absorption.
Read the full breakdown — every affected drug type, severity by severity
Shilajit adds a moderate interaction with antidiabetes drugs by potentially lowering blood sugar further, raising the risk of low blood sugar (hypoglycemia). Altogether, these interactions span 166 individual medications.
Iron's effects on these drugs can often be managed by spacing doses — typically 2 to 4 hours apart — but the exact timing depends on which medication. Because there are many affected drug types here, run your exact medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Shilajit Supreme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Shilajit Supreme interact with 166 drugs. Click any drug to see the details.
2 of the 2 ingredients in Shilajit Supreme interact with drugs. Each result below shows which ingredient is responsible. Shilajit Iron
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Albiglutide interactionAlendronateBinosto, Fosamax
How Alendronate interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate Sodium, Cholecalciferol interactionAlogliptinNesina
How Alogliptin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Alogliptin, Pioglitazone interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Iron + Amphotericin, Tetracycline interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Iron + Benserazide, Levodopa interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Iron + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Iron + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCanagliflozinInvokana
How Canagliflozin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Canagliflozin, Metformin Hydrochloride interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Iron + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronLevodopa Moderate
Interaction Summary
Iron might decrease levodopa levels by reducing its absorption.
Read the full Iron + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronMethyldopa (aldomet) Moderate
Interaction Summary
Iron might decrease methyldopa levels by reducing its absorption.
Read the full Iron + Chlorothiazide, Methyldopa interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Chlorpropamide interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Iron + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Iron + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Iron + Ciprofloxacin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronQuinolone Antibiotics Moderate
Interaction Summary
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Read the full Iron + Clinafloxacin interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
IronBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Iron + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Shilajit Supreme — through 1 ingredient. Tap an ingredient for the detail:
ShilajitAntidiabetes Drugs Moderate
Interaction Summary
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Shilajit Supreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Shilajit
Antidiabetes Drugs
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Iron
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.
Bisphosphonates
Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.
Denosumab (Prolia, Others)
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.
Dolutegravir (Tivicay)
Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.
Integrase Inhibitors
Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.
Levodopa
Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.
Levothyroxine (Synthroid, Others)
Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.
Methyldopa (Aldomet)
Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.
Mycophenolate Mofetil (Cellcept)
Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.
Penicillamine (Cuprimine, Depen)
Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.
Quinolone Antibiotics
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.
Tetracycline Antibiotics
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.
Chloramphenicol
Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.
Brand information
Manufacturer and brand details for Shilajit Supreme, from the product label.
HealthForce SuperFoods
See all HealthForce SuperFoods products- Name
- HealthForce
- City
- Las Vegas
- State
- NV
- Phone Number
- (800) 357-2717
- Web Address
- Healthforce.com
Shilajit Supreme by HealthForce SuperFoods: Common Questions
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The label says purified shilajit — is that enough?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Shilajit Supreme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Shilajit Supreme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Iron
Interacts with 80 drugsIron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...
Read the full Iron monograph → Herb & supplement monographShilajit
Interacts with 86 drugsShilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...
Read the full Shilajit monograph →Sources & How We Checked
Shilajit Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 80 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Iron 72 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
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