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Dietary supplement

The Original SAMe 400 mg Ingredients & Drug Interactions

by NutraLife

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

The Original SAMe 400 mg is a dietary supplement by NutraLife with 1 active ingredient. Its ingredients are commonly taken for depression, osteoarthritis joint pain, liver conditions.Based on those ingredients, 189 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are S-Adenosyl Methionine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of The Original SAMe 400 mg by NutraLife

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

The Original SAMe 400 mg contains one active ingredient: S-Adenosyl Methionine (SAMe), a compound your body makes naturally and uses in methylation reactions — biochemical processes that support mood, joint cartilage, and liver function. Each tablet delivers 400 mg of SAMe.

The remaining ingredients are inactive — cellulose, mannitol, citric acid, stearic acid, and several others that bind, fill, or coat the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mood, liver function, joint health and comfort.
  • We looked for evidence on: Depression, Osteoarthritis, Cirrhosis, Hepatitis C, Alcohol-related liver disease, Fibromyalgia — and 2 related terms.
  • The strongest evidence on file: Same is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Same is rated "Possibly Effective" for Depression.
  • Also on file: Same is rated "Insufficient Reliable Evidence To Rate" for Alcohol-related liver disease, Cirrhosis, Fibromyalgia, Hepatitis C.

SAMe is likely effective for osteoarthritis, meaning there's solid evidence it can help with joint pain and function. For depression, the evidence is weaker — it's possibly effective, so it may help some people, but the research isn't conclusive.

For liver disease (cholestasis), it's also possibly effective. For Alzheimer disease and ADHD, there isn't enough reliable evidence in our data to say whether it works.

The evidence, ingredient by ingredient Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

SAMe is generally well tolerated at standard doses, but side effects do happen — the most common are nausea, diarrhea or constipation, headache, dizziness, and insomnia. Higher doses make side effects more likely.

One important caution: SAMe may trigger or worsen mania if you have bipolar disorder, so talk with your doctor before taking it if that applies to you. During pregnancy, SAMe is rated possibly safe, but lactation data isn't on file — either way, discuss it with your doctor or pharmacist before use if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Same

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Same.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 189 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take serotonergic drugs — antidepressants (SSRIs, SNRIs, tricyclics, MAOIs), certain pain or migraine medications, or tramadol — as they may raise the risk of serotonin syndrome. Also flag levodopa for Parkinson disease, since SAMe may reduce its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

SAMe is most commonly used for osteoarthritis, where the evidence is strongest. If you take antidepressants, certain pain or migraine medications, or levodopa for Parkinson disease, you need to check with your doctor or pharmacist first — interactions are possible and your medications' effectiveness could be affected.

If you have bipolar disorder, mention that too. For anyone else considering SAMe, run your medication list through our checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about The Original SAMe 400 mg, straight from the product label.

Brand NutraLife
Net contents 30 Enteric Coated Tablet(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 293167
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for The Original SAMe 400 mg by NutraLife, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
IngredientAmount% DV
S-Adenosyl Methionine400 mg--

Other ingredients: S-Adenosyl-Methionine Tosylate Disulfate, Cellulose, Mannitol, Citric Acid, Stearic Acid, Silica, Sodium Starch Glycolate, Modified Cellulose Gum, Methacrylic Acid Copolymer, Hydroxypropyl Methylcellulose, Triacetin, Titanium Dioxide, yellow Ochre

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

NutraLife Health Products Incorporated

Formula

400 mg active S-Adenosyl-Methionine per tablet

Nutralife SAMe is kosher certified by Star-K and contains no animal byproducts.

Each Nutralife SAMe tablet contains 400 mg of active S-adenosyl-methionine and is manufactured in full accordance with GMP. Nutralife SAMe continues to be made with the highest quality active S, S isomer SAMe raw material.

Nutralife SAMe enteric coated tablets are kosher certified by: Star-K (Kosher)

Each Nutralife SAMe tablet contains 800 mg SAMe tosylate disulfate, which includes 400 mg of the active ingredient SAMe (S-Adenosyl-methionine).

Formulation

Double strength Manufactured in Accordance with GMP

Clinically shown to maintain: Mood & emotional well being Healthy liver function Joint health and comfort Joint mobility

SAMe is found in every living being. It is an important physiological agent synthesized by the body, and it is involved in over 40 biochemical reactions, some of which effect: Mood SAMe and emotional well-being: SAMe is essential to the manufacturing of many important brain compounds such as neurotransmitters and phospholipids, which are critical for maintaining healthy mood and emotional well-being. Joints SAMe and joint mobility: Clinical studies indicate that SAMe may play an important role in the manufacture of cartilage and that SAMe helps produce proteoglycans, essential components in healthy joint function and mobility. Liver SAMe and liver function: SAMe is involved in many processes of liver. SAMe is essential to maintaining glutathione levels, which is critical for proper liver function. As people age, SAMe levels can decrease. SAMe supplementation may be an important factor in maintaining mobility, and a healthy body and mind. Nutralife SAMe: Nutralife SAMe is the same form that has been available in Europe for over four decades. Nutralife offers SAMe with over 40 years of historical data for both effectiveness and safety. Nutralife SAMe is manufactured and packaged with the highest quality and safety standards. Nutralife SAMe is the original SAMe brand introduced to the United States over three decades ago. Nutralife SAMe tablets are manufactured in a carefully controlled environment and are cold form blister packed to ensure a more than two year stability rating.

Nutralife SAMe is kosher certified by Star-K and contains no animal byproducts. Nutralife SAMe does not contain Talc.

Nutralife SAMe tablets are sealed in blister packs to ensure products safety, quality and freshness.

This product contains no peanuts, eggs, dairy, soy, wheat, yeast, gluten, tree nuts, crustacean shellfish, fish or other animal byproducts.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Clinical studies show that supplementation of 400 mg (or one tablet) a day is effective for most people. Different levels of supplementation may be beneficial to some people.

Precautions

Caution: Do not use if blister foil is punctured or appears in any way to have been tampered with.

Keep out of reach of children.

If you are currently taking prescription anti-depressants, consult your physician before using SAMe. If you suffer from bipolar (manic) depression, do not use this product. If you are pregnant or lactating, consult your physician before taking this product.

If you suffer from bipolar (manic) depression, do not use this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

This product should be stored in a dry, cool place.

See for yourself

The Original SAMe 400 mg by NutraLife label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in The Original SAMe 400 mg by NutraLife

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

S-Adenosyl Methionine

Interacts with
189 drugs
400 mg per serving

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

S-Adenosyl Methionine monograph & interactions

Other (inactive) ingredients: S-Adenosyl-Methionine Tosylate Disulfate, Cellulose, Mannitol, Citric Acid, Stearic Acid, Silica, Sodium Starch Glycolate, Modified Cellulose Gum, Methacrylic Acid Copolymer, Hydroxypropyl Methylcellulose, Triacetin, Titanium Dioxide, Yellow Ochre. These complete the product’s ingredient list but are not active constituents.

Interaction report

The Original SAMe 400 mg by NutraLife Drug Interactions

Want to check YOUR meds against The Original SAMe 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
189Drugs
189 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in The Original SAMe 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

S-Adenosyl Methionine2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for The Original SAMe 400 mg, from the product label.

NutraLife

Name
NutraLife Health Products Inc.
City
Lakewood
State
NJ
ZipCode
08701
Phone Number
1-877-688-7254
Web Address
www.nutralife.com
Pharmacist Counseling Corner

The Original SAMe 400 mg by NutraLife: Common Questions

Does The Original SAMe 400 mg by NutraLife interact with any medications?
Yes. Based on its ingredients, The Original SAMe 400 mg has a known interaction with 189 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
The Original SAMe 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take SAMe if I'm on an antidepressant?
Not without checking first. SAMe itself has serotonergic effects, so combining it with antidepressants (SSRIs, SNRIs, and others) raises the risk of serotonin syndrome, a serious condition. Talk with your doctor or pharmacist before adding this product to your regimen.
What are the most common side effects?
Nausea, diarrhea or constipation, headache, dizziness, and insomnia are most frequent, especially at higher doses. Stomach upset is also common — taking it with food may help. Most people tolerate it well at typical doses, but side effects are dose-dependent.
Does SAMe really work for joint pain?
For osteoarthritis, yes — there's solid evidence SAMe can help with pain and joint function. For depression, the evidence is weaker; it may help some people, but it's not as well proven. For other uses listed here, the research is still thin.
Is SAMe safe if I have bipolar disorder?
SAMe can trigger or worsen mania in people with bipolar disorder. If you have bipolar disorder, do not start this product without guidance from your doctor or psychiatrist.
Can I take it while breastfeeding?
We don't have safety data for SAMe during lactation. Talk with your doctor or pharmacist about whether it's right for you if you're breastfeeding.
What happens if I take levodopa for Parkinson disease?
SAMe may reduce how well levodopa works by changing how your body processes it. If you take levodopa, check with your doctor before starting SAMe.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if The Original SAMe 400 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

The Original SAMe 400 mg label
Go deeper

The Full Monographs Behind The Original SAMe 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

The Original SAMe 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Same 31 references
  1. Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
  2. Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
  3. Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
  4. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
  5. Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
  6. Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
  7. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
  8. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
  9. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
  10. Lipinski JF, Cohen BM, Frankenburg F, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-50.
  11. Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40:111-23. PubMed
  12. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
  13. Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52. PubMed
  14. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37:122-5.
  15. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  16. Charlton CG, Crowell B Jr. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423-31..
  17. Goren JL, Stoll AL, Damico KE, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004;24:1501-7. PubMed
  18. Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol 2005; PubMed
  19. Nelson JC. S-adenosyl methionine (SAMe) augmentation in major depressive disorder. (Editorial). Am J Psychiatry 2010;167:889-91.
  20. Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009; PubMed
  21. Manzillo G, Piccinino F, Surrenti C, et al. Multicentre double-blind placebo-controlled study of intravenous and oral S-adenosyl-L-methionine (SAMe) in cholestatic patients with liver disease. Drug Invest 1992;4 (Suppl 4):90-100. DOI
  22. Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
  23. Pancheri P, Scapicchio P, Delle Chiaie R. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder. Int J Neuro PubMed
  24. Medici V., Virata M. C., Peerson J. M., Stabler S. P., French S. W., Gregory J. F. III, Albanese A., Bowlus C. L., Devaraj S., Panacek E. A., Richards J. R., Halsted C. H. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, ra
  25. Chitiva, H., Audivert, F., and Alvarez, C. Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report. J.Nerv.Ment.Dis. 2012;200(1):99-101. PubMed
  26. Carney, M. W., Edeh, J., Bottiglieri, T., Reynolds, E. M., and Toone, B. K. Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol. 1986;9(4):379-385. PubMed
  27. Miccoli, L., Porro, V., and Bertolino, A. Comparison between the antidepressant activity and of S- adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 1978;33 (3):243-255.
  28. Bacci, Ballerini F., Lopez, Anguera A., Alcaraz, P., and Hernandez, Reyes N. [SAMe in the management of postconcussional syndrome]. Medicina Clinica (Barc.) 1983;80(4):161-164.
  29. Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-6.
  30. Capretto C, Cremona C, and Canaparo L. A double-blind controlled study of S-adenosylmethionine (SAMe) v. ibuprofen in gonarthrosis, coxarthrosis and spondylarthrosis. Clin Trials J 1985;22(1):15-24.
  31. Ancarani E, Biondi B, Bolletta A, et al. Major depression complicating hemodialysis in patients with chronic renal failure: a multicenter, double-blind, controlled clinical trial of S-adenosyl-L-methionine versus placebo. Curr Ther Res 1993;54(6):680-6. DOI

See these in context on the Same monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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