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Dietary supplement

Tryp-to-Zen Ingredients & Drug Interactions

by Symbiotics

Tryp-to-Zen label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tryp-to-Zen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tryp-to-Zen is a dietary supplement by Symbiotics with 1 active ingredient. Its ingredients are commonly taken for high blood pressure, stress and relaxation, sleep support.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Casein derivative. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tryp-to-Zen by Symbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Tryp-to-Zen by Symbiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tryp-to-Zen by Symbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (167 mg) without saying how much of each component you get.

Tryp-to-Zen has one active ingredient: a casein derivative — a peptide (short chain of amino acids) derived from milk protein. The product also contains several inactive ingredients, including sodium caseinate, gelatin, glycerin, water, and titanium dioxide, which serve as the capsule material and binders.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: reduce stress and anxiety naturally.
  • We looked for evidence on: Anxiety, Stress.
  • The closest evidence on file: Casein Peptides is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Casein Peptides is rated "Insufficient Reliable Evidence To Rate" for Stress.

The casein peptides in this product are rated likely effective for atopic dermatitis (eczema) and food allergies, based on available evidence. The same peptide compounds have also shown promise in managing the broader category of atopic disease (allergic and immune-related conditions).

The evidence, ingredient by ingredient Casein Peptides

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Casein peptides are generally well tolerated in healthy adults. However, if you have a milk allergy, you should avoid this product — it's derived directly from milk protein.

The safety data on concentrated supplement doses isn't extensive, so caution is advised, and it's best to avoid high-dose supplements unless your doctor recommends them. There isn't enough reliable safety information to recommend this product in pregnancy or lactation; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Casein Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Casein Peptides.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood pressure-lowering medication (antihypertensive drugs), check your specific medication with the tool on this page before starting Tryp-to-Zen. Combining casein peptides with these drugs carries a Moderate risk of blood pressure dropping too far.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Tryp-to-Zen may help if you're dealing with eczema or food allergies and want a milk-derived peptide supplement. If you take blood pressure medication, check with us first — casein peptides can lower blood pressure, and stacking that effect could be a problem.

Skip it if you have a milk allergy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tryp-to-Zen, straight from the product label.

Brand Symbiotics
Barcode (UPC) 647303010451
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41305
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tryp-to-Zen by Symbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
647303010451
IngredientAmount% DV
Proprietary Blend167 mg--
Casein derivative0 NP--

Other ingredients: Sodium Caseinate, Gelatin, Water, Glycerin, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Clinical study results show that Tryp-to-ZEN(R) can reduce stress and anxiety the natural way with a safe Casein derivative from milk.

Suitable for lactose-free diets.

General Statements

Unlike some other products, including supplements such as Kava Kava and St. John's Wort, there are no known side effects.

You just feel less social, intellectual and emotional anxiety.

Quality and Purity Guaranteed - We guarantee that this product meets the highest standards of quality, purity and freshness.

Made in the U.S.A.

ITEM NO. 07TTZ030

EXPIRATION DATE ON BOTTOM OF CONTAINER

- Helps Manage Stress* - Promotes Relaxation* - Safe & Natural

Brand IP Statement(s)

With Tryp-to-ZEN(R) there's no drowsiness, memory loss, drug interactions or dependency.

Tryp-to-ZEN(R) is nature's way to a relaxed state of being.

Symbiotics(R) and Tryptozen(R) are registered trademarks of Prevention, LLC.

(C)2005

Nature's way to a relaxed state of being(TM)

Precautions

Each bottle is safety sealed with an outer neckband and inner seal. Do not use if either seal is broken or missing.

Do not use if imprinted seal under bottle cap is broken or missing.

KEEP OUT OF REACH OF CHILDREN.

Seals/Symbols

QUALITY GUARANTEE PURITY

Symbiotics(R)

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

Storage

Close tightly and store in a dry place at room temperature.

General

1045-012A v02

FDA Statement of Identity

MILK PEPTIDE SUPPLEMENT

Suggested/Recommended/Usage/Directions

Directions: Take one capsules daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tryp-to-Zen by Symbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tryp-to-Zen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tryp-to-Zen by Symbiotics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Proprietary Blend

167 mg per serving

Other (inactive) ingredients: Sodium Caseinate, Gelatin, Water, Glycerin, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tryp-to-Zen by Symbiotics Drug Interactions

Want to check YOUR meds against Tryp-to-Zen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Casein derivative 172

Individual Drug Interactions

The ingredients in Tryp-to-Zen interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tryp-to-Zen interact with drugs. Each result below shows which ingredient is responsible. Casein derivative

Each ingredient & the kinds of drugs it affects

For each ingredient in Tryp-to-Zen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Casein derivative1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that some casein peptides, including the lactotripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), can modestly reduce blood pressure in patients with hypertension.

Likelihood Probable Evidence B
Casein derivative full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tryp-to-Zen, from the product label.

Symbiotics

See all Symbiotics products
Name
Naturade a division of Prevention, LLC
City
Orange
State
CA
ZipCode
92868
Phone Number
1-800-421-1830
Web Address
www.naturade.com
Pharmacist Counseling Corner

Tryp-to-Zen by Symbiotics: Common Questions

Does Tryp-to-Zen by Symbiotics interact with any medications?
Yes. Based on its ingredients, Tryp-to-Zen has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tryp-to-Zen contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain milk?
Yes — it's made from casein, a protein derived from milk. If you have a milk allergy, avoid this product. It also contains sodium caseinate as an inactive ingredient.
Can I take this if I have eczema?
The casein peptides in Tryp-to-Zen are rated likely effective for atopic dermatitis (eczema), so it may help. Talk with your doctor to see if it's right for your specific situation.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough reliable safety data for pregnancy or lactation. Talk with your pharmacist or doctor before taking it — they can give you personalized advice based on your health.
What are casein peptides?
They're short chains of amino acids (building blocks of protein) derived from milk. Some casein peptides, like the ones in this product, have been studied for their effects on blood pressure and immune-related skin conditions.
What's in the capsule besides the active ingredient?
The capsule itself is made of gelatin, and the blend also contains sodium caseinate, water, glycerin, and titanium dioxide as inactive ingredients — these are binders and fillers that help deliver the active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tryp-to-Zen is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tryp-to-Zen label
Go deeper

The Full Monographs Behind Tryp-to-Zen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Casein Peptides

Interacts with 172 drugs

Casein peptides are small protein fragments made from milk casein, often studied for mild blood pressure support and relaxation. The evidence is limited and mostly modest, so they should not...

Read the full Casein Peptides monograph →
Sources

Sources & How We Checked

Tryp-to-Zen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Casein Peptides 4 references
  1. Cicero AFG, Aubin F, Azais-Braesco V, Borghi C. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials. Am J Hypertens. 2013;26(3): PubMed
  2. Fekete AA, Givens DA, Lovegrove JA. Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials. Nutrients. 2015;7(1):659-81. PubMed
  3. Qin LQ, Xu JY, Dong JY, Zhao Y, van Bladeren P, Zhang W. Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials. Nutr Metab Cardiovasc Dis. 2013;23(5):395-402. PubMed
  4. Turpeinen AM, Järvenpää S, Kautiainen H, Korpela R, Vapaatalo H. Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis. Ann Med. 2013;45(1):51-6. PubMed

See these in context on the Casein Peptides monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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