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Dietary supplement

Turkey Tail Capsules Ingredients & Drug Interactions

by Real Mushrooms

Turkey Tail Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Turkey Tail Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Turkey Tail Capsules is a dietary supplement by Real Mushrooms with 1 active ingredient. Its ingredients are commonly taken for immune support, used alongside cancer care, gut and digestive health.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Turkey Tail Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Turkey Tail Capsules by Real Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Turkey Tail Capsules by Real Mushrooms — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Turkey Tail Capsules by Real Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Turkey Tail Mushroom Extract” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Turkey Tail Capsules contains one active ingredient: beta-1,3/1,6-glucan, a compound extracted from turkey tail mushroom. The glucan is the part of the mushroom studied for its effects on cholesterol and heart health.

The capsule itself is made from hypromellose (a plant-based material), microcrystalline cellulose, and silicon dioxide — these are inactive fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Beta-glucans's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Immune support and general wellness.
  • We looked for evidence on: Exercise-induced respiratory infections, Lower respiratory tract infections, Upper respiratory tract infection (URTI), Wound healing, Gut health, Digestive support — and 1 related terms.
  • The closest evidence on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Lower respiratory tract infections (Natural Medicines).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections, Wound healing.

The beta-glucan in this product is likely effective for two areas. It has shown promise for lowering cholesterol (dyslipidemia) and for supporting coronary heart health.

If you're taking it for those purposes, the data supports a reasonable expectation it may help — though results vary from person to person.

The evidence, ingredient by ingredient Turkey Tail Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated by most people. However, concentrated supplements like this one lack extensive safety data, so use it with caution.

If you're breastfeeding, there's very little research on supplement doses, so talk with your doctor or pharmacist before starting. In rare cases, high oral doses have caused temporary liver enzyme changes; this occurred in one patient taking a very high dose in a trial, and resolved on its own.

Side effects, ingredient by ingredient Turkey Tail Mushroom Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product with your pharmacist or our medication checker if you take immunosuppressants (drugs that dampen your immune system) or blood pressure medications. Beta-glucans may interfere with the former and lower blood pressure further with the latter.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support cholesterol and heart health and you don't take immunosuppressants or blood pressure medications, this product may be worth considering. Check your exact medications with the tool below first — especially if you're on any drugs for immune suppression or blood pressure control.

If you're pregnant or breastfeeding, talk with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Turkey Tail Capsules, straight from the product label.

Brand Real Mushrooms
Barcode (UPC) 628110068071
Net contents 135 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327057
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Turkey Tail Capsules by Real Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
45
UPC/BARCODE
628110068071
IngredientAmount% DV
Turkey Tail Mushroom Extract1000 mg--
Beta-1,3/1,6-Glucan300 mg--

Other ingredients: Hypromellose, Silicon Dioxide, Microcrystalline Cellulose, May contain

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Our quality commitment to you 3rd party lab verified for quality Hot water extracted for improved bioavailability

Our guarantee: This product is verified for active compounds.

There are no added starch, grains or mycelium.

Gluten free Non GMO

Vegan

Immune support Quality grown Verified for active compounds

Formula

Guaranteed potency: 30% beta-glucans per capsule

Mushroom extract powder

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 3 capsules per day.

Storage

Storage: Store in a cool dry place with the lid securely closed.

Precautions

Warning: Keep out of reach of children.

Consult a physician if you are pregnant or nursing; have or had a medical condition; or are taking prescription drugs.

Warning: Consuming this product can expose you to chemicals including lead, which is known to the state of California to cause birth defects or reproductive harm. For more information, go to www.P65Warnings.ca.gov. Learn more at realmushrooms.com/prop-65

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Vegan

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Turkey Tail Capsules by Real Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Turkey Tail Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Turkey Tail Capsules by Real Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Turkey Tail Mushroom Extract

Interacts with
187 drugs
1000 mg per serving Form: Trametes versicolor Extract

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified...

Turkey Tail Mushroom Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Silicon Dioxide, Microcrystalline Cellulose, May contain. These complete the product’s ingredient list but are not active constituents.

Interaction report

Turkey Tail Capsules by Real Mushrooms Drug Interactions

Want to check YOUR meds against Turkey Tail Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
461Drugs
380 Moderate 81 Minor

Ingredients driving the most interactions

Turkey Tail Mushroom Extract 187

Individual Drug Interactions

The ingredients in Turkey Tail Capsules interact with 461 drugs. Click any drug to see the details.

1 of the 1 ingredient in Turkey Tail Capsules interact with drugs. Each result below shows which ingredient is responsible. Turkey Tail Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Turkey Tail Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Turkey Tail Mushroom Extract4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Turkey Tail Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Turkey Tail Capsules, from the product label.

Real Mushrooms

See all Real Mushrooms products
Name
Real Mushrooms Inc.
Street Address
908 17 Ave SW, Suite 303
City
Calgary
ZipCode
AB T2T 0A3
Phone Number
1-800-263-4387
Web Address
realmushrooms.com
Pharmacist Counseling Corner

Turkey Tail Capsules by Real Mushrooms: Common Questions

Does Turkey Tail Capsules by Real Mushrooms interact with any medications?
Yes. Based on its ingredients, Turkey Tail Capsules has a known interaction with 461 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Turkey Tail Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does turkey tail actually work for cholesterol or heart health?
The beta-glucan in this product is likely effective for both high cholesterol and supporting heart health, based on clinical research. That said, results vary person to person, and a supplement is not a replacement for the full treatment plan your doctor recommends.
Are there side effects I should know about?
Beta-glucans are generally well tolerated. The main caution is that concentrated supplements lack extensive safety data compared to food amounts. In one clinical trial at a very high dose, one patient had temporary liver enzyme changes that resolved on their own.
Is it safe to take while breastfeeding?
There's very little research on supplement doses during breastfeeding, so the data isn't there to say either way. Talk with your doctor or pharmacist — they can weigh the potential benefit against what we don't yet know and help you decide if it's right for you.
Can I take this if I'm on blood pressure medication?
Beta-glucans may lower blood pressure in some people, so taking them alongside blood pressure drugs could push your pressure too low. Check with your pharmacist or doctor before starting, especially if your blood pressure is already well controlled.
What are the inactive ingredients?
The capsule contains hypromellose, microcrystalline cellulose, and silicon dioxide — all standard binders and fillers that help hold the supplement together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Turkey Tail Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Turkey Tail Capsules label
Go deeper

The Full Monographs Behind Turkey Tail Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Turkey Tail Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Turkey Tail Mushroom 15 references
  1. Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
  2. Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
  3. Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
  4. Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
  5. Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
  6. Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
  7. Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
  8. Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
  9. Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
  10. Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
  11. Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
  12. Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
  13. Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
  14. Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
  15. Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed

See these in context on the Turkey Tail Mushroom monograph →

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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