Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ultimate Manganese Concentrate Ingredients & Drug Interactions

by Complete H2O Minerals

Ultimate Manganese Concentrate label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Manganese Concentrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Manganese Concentrate is a dietary supplement by Complete H2O Minerals with 2 active ingredients. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate Manganese Concentrate by Complete H2O Minerals

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Manganese Concentrate by Complete H2O Minerals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate Manganese Concentrate by Complete H2O Minerals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: manganese and chloride. Manganese is an essential mineral your body needs in small amounts for bone health, wound healing, and metabolism.

In this liquid form from Complete H2O Minerals, you're getting manganese chloride as the active ingredient. The inactive ingredients are purified water (which makes up the liquid base) and manganese chloride itself, which serves as the mineral source.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Manganese's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain muscle function and joint health.
  • We looked for evidence on: Osteoarthritis, Wound healing, Cartilage health, Joint cushioning, Muscle function.
  • The closest evidence on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis (Natural Medicines).
  • Also on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

Manganese is effective for treating manganese deficiency — a confirmed use backed by evidence. For other uses listed on this product (hay fever, osteoporosis, COPD, weight loss, and osteoarthritis), the evidence isn't established enough to rate them reliably.

That doesn't mean manganese won't help with those conditions; it means the research data we hold doesn't support a confident claim either way.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese taken in normal dietary amounts is generally well tolerated. High-dose supplements, however, carry real risks.

The main concern is neurotoxicity — nerve damage that can resemble Parkinson's disease. Serious cases have been reported in people taking very high doses (100 mg daily) over months to years, causing irreversible neurological damage and even liver injury severe enough to require intensive medical treatment.

The safety data advises against high-dose supplements unless your doctor specifically directs you to take them. For breastfeeding, normal dietary amounts are considered likely safe, but the data shows conflicting signals on whether extra supplementation is safe — talk with your doctor or pharmacist before taking this while nursing.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Ultimate Manganese Concentrate, double-check with your doctor or pharmacist if you take antipsychotic drugs (such as haloperidol), quinolone antibiotics (like ciprofloxacin), or tetracycline antibiotics (like doxycycline). Manganese may worsen side effects with antipsychotics and can reduce how well antibiotics work if taken together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is meant to correct manganese deficiency if your doctor has confirmed you have one. If you take antipsychotic medications or antibiotics (quinolone or tetracycline types), you'll need to check with your doctor or pharmacist before adding this supplement — timing and dosing matter.

Avoid high doses unless a clinician advises otherwise, since manganese can damage your nervous system at high levels. Run your medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Manganese Concentrate, straight from the product label.

Brand Complete H2O Minerals
Net contents 2 Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 252132
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Manganese Concentrate by Complete H2O Minerals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 NP--
Total Fat0 NP--
Manganese750 mcg6%
Chloride990 mcg--

Other ingredients: purified Water, Manganese Chloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Manganese is essential for normal brain and muscle function. It also necessary for forming the cushioning material between the joints. Manganese is also key in many enzyme functions, acting as a catalyst for utilization of choline, biotin, ascorbic acid, and thiamine.

Formulation

In processing, FDA & GMP guidelines are observed and strictly followed.

Complete H2O Minerals contain no preservatives, fillers or artificial ingredients.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease.

General Statements

Quality products for a quality life!

FDA Statement of Identity

Dietary Supplement

Storage

For best results, store in a cool, dark place and use within six months.

Precautions

Note: Do not use if tamper seal is broken or missing.

Suggested/Recommended/Usage/Directions

Recommended Dosage: Adults: 1 mL 750 mcg Children: 0.5 mL 375 mcg or as recommended by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Manganese Concentrate by Complete H2O Minerals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Manganese Concentrate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Manganese Concentrate by Complete H2O Minerals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Manganese

Interacts with
83 drugs
750 mcg per serving

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Chloride

990 mcg per serving

Other (inactive) ingredients: Purified Water, Manganese Chloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Manganese Concentrate by Complete H2O Minerals Drug Interactions

Want to check YOUR meds against Ultimate Manganese Concentrate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Ultimate Manganese Concentrate interact with 83 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ultimate Manganese Concentrate interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Manganese Concentrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate Manganese Concentrate, from the product label.

Complete H2O Minerals

See all Complete H2O Minerals products
Name
Complete H2O Minerals
Street Address
707 Greenwood Road
City
West Columbia
State
SC
ZipCode
29169
Phone Number
1-877-646-3725
Pharmacist Counseling Corner

Ultimate Manganese Concentrate by Complete H2O Minerals: Common Questions

Does Ultimate Manganese Concentrate by Complete H2O Minerals interact with any medications?
Yes. Based on its ingredients, Ultimate Manganese Concentrate has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Manganese Concentrate contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is manganese deficiency common?
True manganese deficiency is rare in people eating a normal diet, but it can happen. Only a doctor can confirm whether you actually have a deficiency — that's when this supplement would be effective. If you're considering it for other reasons (bone health, arthritis, etc.), the evidence we hold isn't strong enough to recommend it.
What happens if I take too much manganese?
High doses can cause neurotoxicity — damage to your nervous system that may resemble Parkinson's disease. Severe cases have required intensive medical treatment, and some damage was irreversible. The safety data is clear: stick to normal dietary amounts or doses your doctor prescribes, and don't self-treat with high-dose supplements.
Is this safe while breastfeeding?
Normal dietary amounts of manganese are considered likely safe while nursing. The data shows mixed signals on whether extra supplementation is safe, though — so talk with your doctor or pharmacist before taking this if you're breastfeeding.
Can I take this with my antibiotics?
It depends on the type. Manganese can reduce how well quinolone and tetracycline antibiotics work if taken together. Ask your doctor or pharmacist about timing — they may suggest you take them several hours apart so they don't interfere with each other.
What is chloride in this product for?
Chloride is paired with manganese to form manganese chloride, the active ingredient source in the liquid. We don't hold interaction data for chloride itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Manganese Concentrate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Manganese Concentrate label
Go deeper

The Full Monographs Behind Ultimate Manganese Concentrate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Ultimate Manganese Concentrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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