Interactions on record — worth a quick check against your medications. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

Ultra Natural Prostate Ingredients & Drug Interactions

by Life Extension

Ultra Natural Prostate label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Natural Prostate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Natural Prostate is a dietary supplement by Life Extension with 11 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 1,364 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ApresFlex(TM) (Boswellia serrata) extract, ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts, USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Natural Prostate by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Natural Prostate by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultra Natural Prostate by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 9 of its 11 active ingredients.
  • “Proprietary Enterolactone Precursors Blend” is a proprietary blend — the label gives one combined amount (20.15 mg) without saying how much of each component you get.
  • “USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM)” is listed as a grouped ingredient — the label gives one combined amount (320 mg) without saying how much of each component you get.

Ultra Natural Prostate contains 11 active ingredients chosen for prostate health. Pygeum extract is the standout: clinical evidence shows it's likely effective for benign prostatic hyperplasia (enlarged prostate).

Stinging nettle, pumpkin seed oil, and boron all have insufficient or mixed evidence for prostate benefit, though stinging nettle may possibly help with diabetes and hay fever. Lycopene, the carotenoid from tomatoes, possibly helps with prostate cancer risk.

The product also includes a Proprietary Enterolactone Precursors blend and several plant extracts — saw palmetto, flower pollen, boswellia, and flax lignans — whose effectiveness for prostate health is not rated in our data. The remaining inactive ingredients are standard softgel capsule materials: gelatin, glycerin, water, sunflower lecithin, beeswax, maltodextrin, and rosemary extract.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support for a healthy prostate.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Overactive bladder, Prostate cancer, Prostatitis, Urinary symptoms — and 1 related terms.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Lycopene is rated "Possibly Effective" for Prostate cancer.
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).

The strongest evidence here supports pygeum extract for benign prostatic hyperplasia — it's likely effective based on clinical research. Lycopene is possibly effective for prostate cancer risk reduction.

The other ingredients have insufficient evidence, mixed results, or no effectiveness rating in our data for prostate health specifically. Boron, for example, is likely effective only for boron deficiency and has insufficient evidence for prostate use.

Stinging nettle is possibly effective for diabetes but not rated for prostate conditions. If you're seeking a supplement primarily for prostate support, pygeum is your strongest candidate here; the rest remain unproven for that specific goal.

The evidence, ingredient by ingredient Boron Lycopene Flaxseed Pygeum Stinging Nettle Saw Palmetto Boswellia Serrata Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron is generally well tolerated at supplement doses below 20 mg daily, though high doses can be toxic. Lycopene supplements are generally well tolerated orally; gastrointestinal side effects like diarrhea, nausea, and abdominal bloating can occur.

Pygeum is generally well tolerated short-term but quality and long-term safety data are limited; nausea and abdominal pain appear similar to placebo in trials. Stinging nettle is generally well tolerated for most adults, though constipation and diarrhea are reported; rare cases of liver injury have been documented after prolonged use.

Pumpkin seed oil is generally safe; mild abdominal discomfort, diarrhea, nausea, and vomiting are the most common side effects, with anaphylaxis reported rarely.

Side effects, ingredient by ingredient Boron Lycopene Flaxseed Pygeum Stinging Nettle Saw Palmetto Boswellia Serrata Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Boswellia Serrata, Lycopene, Stinging Nettle, Pumpkin, Flaxseed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,362 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications carefully if you take warfarin or other blood thinners — stinging nettle may reduce their effect. Also double-check if you're on antidiabetes drugs, diuretics, or lithium; stinging nettle and pumpkin seed oil may interact with these.

Antiplatelet drugs like aspirin might see increased bleeding risk with lycopene, though this is theoretical. Run your exact prescriptions through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ultra Natural Prostate is best suited for men seeking prostate support with clinical backing for pygeum — though several ingredients lack strong evidence. If you take warfarin, other blood thinners, antidiabetes drugs, diuretics, or lithium, check your exact medications with the tool below before starting; stinging nettle in this formula may interfere.

Talk to your pharmacist before adding this to your routine, especially if you have a complex medication list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Natural Prostate, straight from the product label.

Brand Life Extension
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 48040
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Natural Prostate by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Boron3 mg--
Lycopene10 mg--
Proprietary Enterolactone Precursors Blend20.15 mg--
Pygeum (Pygeum africanum) extract100 mg--
Sterols272 mg--
Stinging Nettle (Urtica dioica) extract240 mg--
USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM)320 mg--
Graminex(R) Flower Pollen Extract(TM)252 mg--
ApresFlex(TM) (Boswellia serrata) extract70 mg--
Pumpkin seed oil (Cucurbita pepo) extract200 mg--
Phytosterol Complex678 mg--
HMRlignan Norway Spruce0 NP--
ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts0 NP--

Other ingredients: Gelatin, Glycerin, purified Water, Sunflower Lecithin, Beeswax, Maltodextrin, Rosemary extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

01695A Rev.9/11

Support for a Healthy Prostate

Storage

Store tightly closed in a cool, dry place

Formula

Contains soybeans. Contains corn.

with ApresFlex(TM) and Standardized Lignans

Precautions

Contains soybeans. Contains corn.

Brand IP Statement(s)

For Longer Life(R)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Natural Prostate by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Natural Prostate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Natural Prostate by Life Extension

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Boron

No known
interactions
3 mg per serving Form: Boron Aspartate, Boron Citrate, Boron Glycinate

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Lycopene

Interacts with
122 drugs
10 mg per serving Form: natural Tomato extract

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Proprietary Enterolactone Precursors Blend

20.15 mg per serving

Pygeum (Pygeum africanum) extract

No known
interactions
100 mg per serving

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum (Pygeum africanum) extract monograph & interactions

Stinging Nettle (Urtica dioica) extract

Interacts with
164 drugs
240 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Stinging Nettle (Urtica dioica) extract monograph & interactions

USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM)

Interacts with
174 drugs
320 mg per serving Form: Total Fatty Acids

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM) monograph & interactions
  • › Sterols

Graminex(R) Flower Pollen Extract(TM)

252 mg per serving Form: Secale cereale

ApresFlex(TM) (Boswellia serrata) extract

Interacts with
952 drugs
70 mg per serving Form: 3-0-Acetyl-11-Keto-B-Boswellic Acid

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

ApresFlex(TM) (Boswellia serrata) extract monograph & interactions

Pumpkin seed oil (Cucurbita pepo) extract

Interacts with
1 drug
200 mg per serving Form: Total Fatty Acids

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed oil (Cucurbita pepo) extract monograph & interactions

Phytosterol Complex

678 mg per serving Form: free Beta-Sitosterol, free total Sterols

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Sunflower Lecithin, Beeswax, Maltodextrin, Rosemary extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Natural Prostate by Life Extension Drug Interactions

Want to check YOUR meds against Ultra Natural Prostate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,364Drugs
1,364 Moderate

Ingredients driving the most interactions

ApresFlex(TM) (Boswellia serrata) extract 952
ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts 597
USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM) 174
Stinging Nettle (Urtica dioica) extract 164
Lycopene 122

Individual Drug Interactions

The ingredients in Ultra Natural Prostate interact with 1,364 drugs. Click any drug to see the details.

6 of the 11 ingredients in Ultra Natural Prostate interact with drugs. Each result below shows which ingredient is responsible. ApresFlex(TM) (Boswellia serrata) extract ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM) Stinging Nettle (Urtica dioica) extract Lycopene Pumpkin seed oil (Cucurbita pepo) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Natural Prostate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

ApresFlex(TM) (Boswellia serrata) extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
ApresFlex(TM) (Boswellia serrata) extract full monograph & interactions

ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
ActiFla Flax (Linum usitatissimum L.) (seed) lignans extracts full monograph & interactions

USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM)3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
USPlus(R) Saw Palmetto (Serenoa repens) CO2 DeepExtract(TM) full monograph & interactions

Stinging Nettle (Urtica dioica) extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle (Urtica dioica) extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Pumpkin seed oil (Cucurbita pepo) extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed oil (Cucurbita pepo) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Natural Prostate, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
Florida
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Ultra Natural Prostate by Life Extension: Common Questions

Does Ultra Natural Prostate by Life Extension interact with any medications?
Yes. Based on its ingredients, Ultra Natural Prostate has a known interaction with 1,364 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Natural Prostate contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for an enlarged prostate?
Pygeum extract in this formula is likely effective for benign prostatic hyperplasia based on clinical evidence. The other ingredients—stinging nettle, pumpkin seed oil, boron, and lycopene—either lack sufficient evidence for prostate health or show mixed results in our data. Talk to your doctor or pharmacist about whether this formula matches your specific symptoms.
Is it safe to take if I'm pregnant or breastfeeding?
Boron should be avoided in pregnancy and breastfeeding due to safety concerns. Lycopene supplements are not well studied in pregnancy or while breastfeeding — food amounts are fine, but supplements should only be used if your doctor advises. Pygeum and stinging nettle have insufficient safety data, so they're best avoided in both pregnancy and breastfeeding. Talk to your doctor or pharmacist for personalized guidance.
What side effects should I watch for?
The most common are gastrointestinal: diarrhea, nausea, abdominal discomfort, and constipation from various ingredients. Boron at high doses can cause skin rash and hair loss. Pumpkin seed oil rarely triggers anaphylaxis. Stop and contact your pharmacist if you notice unusual reactions or if side effects don't resolve after a few days.
Can I take this with my blood thinner?
This depends on the specific blood thinner and the dose of this product. Stinging nettle may reduce warfarin's effect, and lycopene may theoretically increase bleeding risk. This is a conversation you must have with your pharmacist or doctor before starting—use the medication checker on this page with your exact prescriptions.
What's in this product besides the active ingredients?
The softgel capsule itself contains gelatin, glycerin, water, sunflower lecithin, beeswax, maltodextrin, and rosemary extract. These are inactive ingredients used to form and preserve the capsule. There are no added fillers beyond what's listed.
Can I check if this interacts with my diabetes or lithium medication?
Yes—stinging nettle in this formula may lower blood sugar additively with diabetes drugs and may reduce how your kidneys clear lithium, raising its levels. Pumpkin seed oil also affects lithium. Use the medication search tool on this page with your exact prescriptions, or call your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Natural Prostate label
Go deeper

The Full Monographs Behind Ultra Natural Prostate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Ultra Natural Prostate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Lycopene 10 references
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Pygeum 3 references
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Stinging Nettle 23 references
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Saw Palmetto 22 references
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Boswellia Serrata 16 references
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Pumpkin 5 references
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Flaxseed 37 references
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