Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Unflavored Whey Protein Plus Elite Series Ingredients & Drug Interactions

by Six Star Pro Nutrition

Unflavored Whey Protein Plus Elite Series label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Unflavored Whey Protein Plus Elite Series against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Unflavored Whey Protein Plus Elite Series is a dietary supplement by Six Star Pro Nutrition with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 305 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains three active ingredients: sodium, calcium, and iron. Sodium is an electrolyte your body needs in small amounts for nerve and muscle function, but this product's sodium content may be a concern if you're watching your intake.

Calcium supports bone health and plays roles in muscle and nerve signaling. Iron is essential for making red blood cells and carrying oxygen throughout your body — it's especially important if you have iron-deficiency anemia or are pregnant.

The product also contains inactive ingredients including whey protein blend, maltodextrin, calcium carbonate, soy lecithin, and digestive enzymes (papain and amylase) to help break down protein.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Muscle protein support and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Muscle recovery, Strength training support, Lean muscle mass.
  • The closest evidence on file: Iron is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Iron is rated "Insufficient Reliable Evidence To Rate" for Postoperative recovery.

Calcium in this product is rated Effective for preventing kidney failure, treating heartburn (dyspepsia), correcting low calcium levels (hypocalcemia), and treating high potassium (hyperkalemia), and Likely Effective for osteoporosis. Iron is rated Effective for iron-deficiency anemia, anemia of chronic disease, and pregnancy-related iron deficiency, and Possibly Effective for heart failure.

We don't have effectiveness data in our files for sodium at the doses in a supplement.

The evidence, ingredient by ingredient Sodium Calcium Iron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium and iron are both generally well tolerated when used at recommended amounts. The most common side effects of calcium are belching, constipation, diarrhea, and stomach upset.

Iron commonly causes abdominal pain, constipation, diarrhea, and nausea. Sodium, on the other hand, is essential in small amounts, but too much is linked to high blood pressure and heart strain — normal dietary sodium is fine, but avoid sodium supplements or very high intake without medical advice.

During pregnancy, calcium is Likely Safe and iron is Likely Safe. During breastfeeding, calcium is Likely Safe, but iron is rated Possibly Unsafe — talk with your prenatal or postpartum provider before taking this product if you're nursing.

Side effects, ingredient by ingredient Sodium Calcium Iron

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Calcium, Iron, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 305 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check if you're on HIV integrase inhibitors like dolutegravir or elvitegravir (Major interaction with calcium), blood-pressure medications, thyroid hormone (levothyroxine), bisphosphonates or other bone medications, tetracycline or quinolone antibiotics, lithium, or corticosteroids. The calcium and iron here can reduce how much of those medications your body absorbs.

If you take any prescription drug, run it through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be useful if you're looking for supplemental calcium and iron, especially if you have iron-deficiency anemia or need bone support. But the sodium content and multiple drug interactions mean you need to check your medications carefully — particularly if you take HIV drugs, antibiotics, blood-pressure or thyroid medications, or any of the 300+ medications that interact with these three ingredients.

Talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Unflavored Whey Protein Plus Elite Series, straight from the product label.

Brand Six Star Pro Nutrition
Barcode (UPC) 631656708844
Net contents 2 lbs; 907 Gram(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62859
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
32 Gram(s)
Maximum serving Sizes:
64 Gram(s)
Servings per container
28
UPC/BARCODE
631656708844
IngredientAmount% DV
Calories240 Calorie(s), 120 Calorie(s)--
Total Carbohydrates12 Gram(s), 6 Gram(s)4%, 2%
Sugar2 Gram(s), 1 Gram(s)--
Calories from Fat20 Calorie(s), 10 Calorie(s)--
Protein40 Gram(s), 20 Gram(s)80%, 40%
Saturated Fat1 Gram(s), 0.5 Gram(s)5%, 3%
Sodium200 mg, 100 mg8%, 4%
Cholesterol70 mg, 35 mg23%, 12%
Calcium700 mg, 350 mg70%, 35%
Iron3.6 mg, 1.8 mg20%, 10%
Total Fat2 Gram(s), 1 Gram(s)3%, 2%

Other ingredients: Whey Protein Plus Blend, Maltodextrin, Calcium Carbonate, Soy Lecithin, Papain, Amylase, Gum Blend, isolated Soy Protein

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

FROM AMERICA'S #1 SELLING BODY BUILDING SUPPLEMENT BRAND

20 YEARS of EXCELLENCE

LEADER IN SCIENCE A PORTION OF EVERY DOLLAR TO MORE RESEARCH

Manufactured according to cGMP standards, as is required for all dietary supplements.

~ Mixes easily for your convenience

~ Boosts strength for better workouts when used to meet your daily requirements

~ Helps you recover after workouts

Now you don’t just have to drink your whey protein – with this multi-purpose protein mix, you can enjoy it any number of ways and give your body the nutrition it craves.

NEW

GREAT FOR ALL SMOOTHIE RECIPES

MIX WITH ANYTHING!

Multi-purpose mix

Mixes Instantly

Note: This product is sold by weight, so some settling may occur.

Made in the U.S.A. from domestic and international ingredients.

Formulation

GUARANTEED BANNED SUBSTANCE FREE

GLUTEN FREE

No Artificial Sweeteners or Colors

Zero Aspartame

Seals/Symbols

cGMP MANUFACTURED

MADE IN THE USA FROM INTERNATIONAL INGREDIENTS

Brand IP Statement(s)

Why Six Star Unflavored Whey Protein Plus is the Smarter Choice Six Star Unflavored Whey Protein Plus is from the makers of MuscleTech, America’s #1 Selling Body Building Supplement Brand, so you know it’s a powerful formula you can trust. And unlike cheaper formulas, Six Star Unflavored Whey Protein Plus is powered primarily by ultra-filtered and instantized protein for fast absorption and easy mixing. Trust Six Star Unflavored Whey Protein Plus for the best formula, best taste and best results!

What Are the Benefits of Six Star Unflavored Whey Protein Plus

How do I use Six Star Unflavored Whey Protein Plus? Six Star Unflavored Whey Protein Plus is the perfect way to add high-quality protein to your favorite shakes and recipes.

Getting the protein you need is important to achieving your fitness goals, and Six Star Unflavored Whey Protein Plus can help you meet your daily requirements in a convenient way, whenever and however you choose!

From the makers of Muscletech Research & Development

Six Star Whey Protein Plus is manufactured according to cGMP standards, as is required for all dietary supplements.

MuscleTech is America's #1 Selling Body Building Supplement Brand based on cumulative wholesale dollar sales 2001 to present.

2015.

Formula

Who is Six Star Unflavored Whey Protein Plus For? ~ Active Men & Women ~ Strength Trainers ~ Athletes ~ Fitness Enthusiasts ~ Body Builders ~ Endurance Athletes

~ Features ultra-pure and instantized protein

~ Provides fast-absorbing BCAAs (leucine, isoleucine and valine) ~ Ultra-filtered whey to reduce fat, lactose and impurities

FLEXIBLE FORMULA 20G PROTEIN PER 1 SCOOP 40G PROTEIN PER 2 SCOOPS

Enhance Any Recipe with Added Protein Instantized Protein for Fast Absorption & Easy Mixing

Low in Fat

Contains milk and soy.

Suggested/Recommended/Usage/Directions

It’s so versatile you can use it in oatmeal, pancakes, sweet or savory baked goods, and more to make delicious meals with an added nutritional boost!

TRY THESE TASTY RECIPES! Strawberry Banana Explosion Smoothie 1 scoop Six Star Unflavored Whey Protein Plus ~ 1/2 cup skim milk ~ 1/2 cup fresh/frozen strawberries ~ 1 full banana ~ 4 to 5 ice cubes ~ 1 tbsp. flaxseed powder DIRECTIONS 1. Put milk and ice cubes in a blender and blend until smooth. 2. Add rest of ingredients and blend for 20 seconds.

Protein Porridge Pancakes INGREDIENTS ~ 1 Scoop Six Star Unflavored Whey Protein Plus ~ 1 scoop porridge oats ~ 1 large egg ~ 245mL almond milk ~ cinnamon DIRECTIONS 1. In a bowl, combine all ingredients. 2. Scoop a large ladle of protein porridge onto a hot pan and form into a pancake. 3. Cook until golden on both sides. Batter makes approximately 4 large porridge protein pancakes.

Protein Banana Bread Muffins INGREDIENTS ~ 1/4 cup Six Star Unflavored Whey Protein Plus ~ 1 cup whole wheat flour ~ 3/4 tsp. baking powder ~ 1 tsp. baking soda ~ 1 tsp. cinnamon ~ 1/2 cup plain Greek yogurt ~ 2 eggs ~ 2 large bananas, mashed ~ 1/2 cup milk of choice ~ 1/2 tsp. vanilla extract DIRECTIONS 1. Mix dry ingredients together in a mixing bowl. 2. Add in Greek yogurt, eggs, mashed bananas, milk and vanilla extract and stir well. 3. Spray muffin pan with non-stick spray and pour batter into pan. 4. Bake at 350°F for 25 to 30 minutes or until a toothpick is clean when stuck into the center of the muffins.

Shake container before use.

How to Make the Perfect Whey Protein Shake: STIR SHAKE BLEND Tip: Try blending with ice, your favorite fruit, juice, peanut butter or anything else you enjoy for a delicious smoothie. Directions: Mix 1 to 2 servings (1 to 2 scoops) in 4 to 8 oz. of cold water or skim milk according to taste in a glass or shaker cup. Use between major meals and before and after exercise. Drink 8 glasses of water daily for general good health. Read the entire label before use and follow directions provided.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Contains milk and soy. Processed in a facility that also processes egg, wheat, shellfish, fish oil, tree nut, and peanut ingredients.

WARNING: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Consult a medical doctor before starting any diet or exercise program.

Do not use if packaging has been tampered with.

NOTICE: Use this product as a food supplement only. Do not use for weight reduction.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General

11445US 0715

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Unflavored Whey Protein Plus Elite Series label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size32 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 Gram(s) per serving

Protein

40 Gram(s) per serving

Sodium

Interacts with
205 drugs
200 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
700 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Iron

Interacts with
80 drugs
3.6 mg per serving

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Other (inactive) ingredients: Whey Protein Plus Blend, Maltodextrin, Calcium Carbonate, Soy Lecithin, Papain, Amylase, Gum Blend, Isolated Soy Protein. These complete the product’s ingredient list but are not active constituents.

Interaction report

Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition Drug Interactions

Want to check YOUR meds against Unflavored Whey Protein Plus Elite Series?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
305Drugs
7 Major 295 Moderate 3 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168
Iron 80

Individual Drug Interactions

The ingredients in Unflavored Whey Protein Plus Elite Series interact with 305 drugs. Click any drug to see the details.

3 of the 5 ingredients in Unflavored Whey Protein Plus Elite Series interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium Iron

Each ingredient & the kinds of drugs it affects

For each ingredient in Unflavored Whey Protein Plus Elite Series with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Unflavored Whey Protein Plus Elite Series, from the product label.

Six Star Pro Nutrition

See all Six Star Pro Nutrition products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 N. Market St., Ste 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition: Common Questions

Does Unflavored Whey Protein Plus Elite Series by Six Star Pro Nutrition interact with any medications?
Yes. Based on its ingredients, Unflavored Whey Protein Plus Elite Series has a known interaction with 305 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Unflavored Whey Protein Plus Elite Series contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on levothyroxine for thyroid?
Calcium and iron both reduce how well your body absorbs levothyroxine, so you'd need to space them out — take your thyroid pill at least 4 hours before or after this product. Talk with your pharmacist about the best timing for you.
What's the sodium content in this product?
The product facts don't specify the exact amount of sodium per serving, so you'll want to check the nutrition label on the container or contact the manufacturer, especially if you're watching salt intake for blood pressure or heart health.
Is this safe to take while I'm pregnant?
Calcium is Likely Safe and iron is Likely Safe during pregnancy, which is why both are often recommended. But run the specific product past your prenatal care provider — they know your full medical picture and can advise on dose and timing.
Will this help with my anemia?
Iron in this product is rated Effective for iron-deficiency anemia and anemia of chronic disease, so it may help — but first confirm with your doctor that iron deficiency is actually what you have and that this dose is right for you.
What side effects might I notice?
Iron commonly causes constipation, diarrhea, nausea, and stomach pain. Calcium often causes belching, constipation, or upset stomach. Most people tolerate these ingredients well at recommended doses, but if side effects are bothersome, tell your pharmacist.
Can I take this with my bisphosphonate for osteoporosis?
Iron reduces how well your body absorbs bisphosphonates, so you'd need to separate them by at least two hours. Talk with your pharmacist about the best timing to keep your bone medication working.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Unflavored Whey Protein Plus Elite Series label
Go deeper

The Full Monographs Behind Unflavored Whey Protein Plus Elite Series’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph →
Sources

Sources & How We Checked

Unflavored Whey Protein Plus Elite Series's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 172 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
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  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Iron 72 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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