VegZymes Ingredients & Drug Interactions
by BiOptimizers
What is this page for?
First and foremost: checking VegZymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
VegZymes is a dietary supplement by BiOptimizers with 15 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine Hydrochloride, Protease Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against VegZymes by BiOptimizers
Ask about any prescription or over-the-counter medication and we check it for interactions with VegZymes by BiOptimizers — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of VegZymes by BiOptimizers
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
VegZymes contains 16 active ingredients, most of them digestive enzymes designed to break down different types of food. You'll find protease (breaks down protein), lipase (breaks down fat), amylase (breaks down carbohydrates), and several plant-based enzymes like cellulase, hemicellulase, and pectinase.
The formula also includes betaine hydrochloride, which increases stomach acidity to help digestion. There are three inactive ingredients: rice extract, cellulose, and water.
Does it work?
Not established
The data we hold doesn't establish effectiveness for any of the conditions these ingredients are studied for. Both the lipase varieties and phytase show insufficient reliable evidence for digestive conditions like dyspepsia and inflammatory bowel disease (IBD).
Betaine hydrochloride also has insufficient evidence for dyspepsia and several other digestive and immune conditions. Protease and the other enzyme ingredients don't have effectiveness ratings in our data.
How safe is it?
Well-documented data
These enzymes are generally well tolerated by adults, though protease and lipase may cause digestive upset or allergic reactions in some people. Betaine hydrochloride can irritate the stomach and isn't safe if you have ulcers, gastritis, or true acid reflux — it may trigger heartburn.
If you're pregnant, the safety data advises against betaine hydrochloride. For protease, phytase, and lipase, there isn't enough data to know if they're safe in pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice before use.
Phytase has rare reports of allergic reactions in people with occupational exposure; protease similarly can rarely trigger allergic responses.
Meds to double-check
Minor interactions only
Before you start VegZymes, double-check any H2-blockers, antacids, or proton pump inhibitors (PPIs) you're on — betaine hydrochloride may weaken their effects. No interactions are documented for the other active ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.
VegZymes is for people looking to support general digestion with a broad-spectrum enzyme blend. If you take acid-reducing medications (H2-blockers, antacids, or PPIs), check with us or your pharmacist first — betaine hydrochloride may reduce how well they work.
The same goes if you have a history of ulcers or acid reflux. And if you're pregnant or breastfeeding, run it past your doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about VegZymes, straight from the product label.
| Brand | BiOptimizers |
|---|---|
| Barcode (UPC) | 0689176916614 |
| Net contents | 120 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 334481 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for VegZymes by BiOptimizers, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Betaine Hydrochloride | 10 mg | -- |
| Cellulase | 0 NP | -- |
| InnoSlim | 45 mg | -- |
| Lipase, Fungal | 0 NP | -- |
| AstraZyme | 35 mg | -- |
| Enzyme Blend | 68.58 mg | -- |
| Cellulase | 0 NP | -- |
| Lipase Blend | 20 mg | -- |
| Pectinase S | 0 NP | -- |
| Protease FNP | 0 NP | -- |
| Protease Blend | 33.56 mg | -- |
Other ingredients: Rice extract, Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
VegZymes is an advanced enzyme formulation designed to aid digestion on a plant-based diet. Each vegan-friendly capsule contains a unique blend of 17 enzymes to assist in the breakdown of fibers, starches, sugars, fats, and proteins. These full spectrum enzymes are designed to be taken with your plant-based meals or protein shakes.
Suggested/Recommended/Usage/Directions
Directions: Take 2 capsules with each meal. (May take 1-3 capsules with each meal and 1-2 capsules between meals.)
Storage
Store in a cool/dry location.
Precautions
Caution: Keep out of reach of children.
Do not use if ulcer or gastritis are present. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement.
To report a serious adverse event, or obtain product information, contact 1(800) 719-2467 or visit: BiOptimizers.com
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Optimized digestive solutions
Vegan
Gluten-free Soy-free
Supports plant-based digestion
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
VegZymes by BiOptimizers label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in VegZymes by BiOptimizers
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Betaine Hydrochloride
Interacts with36 drugs
Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...
Betaine Hydrochloride monograph & interactionsInnoSlim
AstraZyme
Enzyme Blend
- › Amylase
- › Alpha-Galactosidase
- › Xylanase
- › Beta-Glucanase
- › Phytase
- › Hemicellulase
- › Cellulase
- › Cellulase
- › Pectinase S
- › Protease FNP
Lipase Blend
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase Blend monograph & interactions- › Lipase
- › Lipase, Fungal
Protease Blend
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Protease Blend monograph & interactions- › Protease
Other (inactive) ingredients: Rice extract, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
VegZymes by BiOptimizers Drug Interactions
HelloPharmacist Interaction Report
VegZymes by BiOptimizers is a digestive enzyme formula with one ingredient that interacts with medications: betaine hydrochloride.
This ingredient increases stomach acid and can reduce how well acid-reducing drugs work — including H2-blockers (like famotidine), antacids, and proton pump inhibitors (PPIs, like omeprazole). All three categories carry Minor severity.
Read the full breakdown — every affected drug type, severity by severity
Several other active ingredients in this formula — amylase, alpha-galactosidase, xylanase, beta-glucanase, hemicellulase, cellulase, InnoSlim, AstraZyme, and pectinase S — we could not check because we hold no interaction data for them.
Altogether, these interactions span 36 individual medications. To be sure your specific prescriptions won't be affected, use the search tool below to look up your exact medications before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against VegZymes?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in VegZymes interact with 38 drugs. Click any drug to see the details.
2 of the 15 ingredients in VegZymes interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride Protease Blend
WarfarinWarfarin
How Warfarin interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Protease BlendWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Protease Blend + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Protease BlendWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Protease Blend + Warfarin Sodium interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Alginic Acid, Aluminum Hydroxide interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aluminum, Magnesium (otc Drug) interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Aspirin, Omeprazole interactionBismuth Subcarbonate, Calcium Carbonate, OpiumDiabismul
How Bismuth Subcarbonate, Calcium Carbonate, Opium interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Bismuth Subcarbonate, Calcium Carbonate, Opium interactionCalcium CarbonateAdcal, Adcal-D3, Calcichew, Os-Cal, Tums
How Calcium Carbonate interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Calcium Carbonate interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full Betaine Hydrochloride + Cimetidine interactionDexlansoprazoleDexilant Solutab
How Dexlansoprazole interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Dexlansoprazole interactionDihydroxyaluminum Sodium CarbonateRolaids
How Dihydroxyaluminum Sodium Carbonate interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Dihydroxyaluminum Sodium Carbonate interactionEsomeprazoleNexium
How Esomeprazole interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Esomeprazole interactionEsomeprazole MagnesiumNexium 24hr
How Esomeprazole Magnesium interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Esomeprazole Magnesium interactionEsomeprazole StrontiumEsomeprazole Strontium
How Esomeprazole Strontium interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Esomeprazole Strontium interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Esomeprazole, Naproxen interactionFamotidineFamotidine, Famotidine Injection, Pepcid, Pepcid AC
How Famotidine interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full Betaine Hydrochloride + Famotidine interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full Betaine Hydrochloride + Famotidine, Ibuprofen interactionLansoprazolePrevacid
How Lansoprazole interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Lansoprazole interactionLansoprazole, Amoxicillin, ClarithromycinPrevpac
How Lansoprazole, Amoxicillin, Clarithromycin interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hydrochloride + Lansoprazole, Amoxicillin, Clarithromycin interactionMagaldrateRiopan
How Magaldrate interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Magaldrate interactionMagnesium Sulfate (prescription Drug)Bilagog, Magnesium Sulfate
How Magnesium Sulfate (prescription Drug) interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full Betaine Hydrochloride + Magnesium Sulfate (prescription Drug) interactionNizatidineAxid, Axid Injection
How Nizatidine interacts with VegZymes — through 1 ingredient. Tap an ingredient for the detail:
Betaine HydrochlorideH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full Betaine Hydrochloride + Nizatidine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in VegZymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Betaine Hydrochloride
Antacids
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.
H2-Blockers
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.
Proton Pump Inhibitors (Ppis)
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs
Protease Blend
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for VegZymes, from the product label.
BiOptimizers
See all BiOptimizers products- Name
- BiOptimizers USA Inc.
- Street Address
- 5470 Kietzke Lane, Suite 300
- City
- Reno
- State
- NV
- ZipCode
- 89511
- Phone Number
- 1 (800) 719-2467
VegZymes by BiOptimizers: Common Questions
Does VegZymes by BiOptimizers interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this actually help with digestion?
Can I take this if I'm pregnant?
Is it safe to breastfeed while taking this?
Can this cause side effects?
What's betaine hydrochloride doing in a digestive enzyme formula?
Are there any fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if VegZymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind VegZymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Betaine Hydrochloride
Interacts with 36 drugsBetaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...
Read the full Betaine Hydrochloride monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographPapain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph →Sources & How We Checked
VegZymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Betaine Hydrochloride 2 references
- Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
- Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed
See these in context on the Betaine Hydrochloride monograph →
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
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