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Dietary supplement

VegZymes Ingredients & Drug Interactions

by BiOptimizers

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

VegZymes is a dietary supplement by BiOptimizers with 15 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine Hydrochloride, Protease Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of VegZymes by BiOptimizers

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 16 active ingredients.
  • “Enzyme Blend” is a proprietary blend — the label gives one combined amount (68.58 mg) without saying how much of each component you get.
  • “Lipase Blend” is a proprietary blend — the label gives one combined amount (20 mg) without saying how much of each component you get.
  • “Protease Blend” is a proprietary blend — the label gives one combined amount (33.56 mg) without saying how much of each component you get.

VegZymes contains 16 active ingredients, most of them digestive enzymes designed to break down different types of food. You'll find protease (breaks down protein), lipase (breaks down fat), amylase (breaks down carbohydrates), and several plant-based enzymes like cellulase, hemicellulase, and pectinase.

The formula also includes betaine hydrochloride, which increases stomach acidity to help digestion. There are three inactive ingredients: rice extract, cellulose, and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: aid digestion on a plant-based diet.
  • We looked for evidence on: Dyspepsia, Celiac disease, Inflammatory bowel disease (IBD), Food allergies, Bloating and gas, Indigestion — and 2 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD) (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Celiac disease.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Food allergies.

The data we hold doesn't establish effectiveness for any of the conditions these ingredients are studied for. Both the lipase varieties and phytase show insufficient reliable evidence for digestive conditions like dyspepsia and inflammatory bowel disease (IBD).

Betaine hydrochloride also has insufficient evidence for dyspepsia and several other digestive and immune conditions. Protease and the other enzyme ingredients don't have effectiveness ratings in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These enzymes are generally well tolerated by adults, though protease and lipase may cause digestive upset or allergic reactions in some people. Betaine hydrochloride can irritate the stomach and isn't safe if you have ulcers, gastritis, or true acid reflux — it may trigger heartburn.

If you're pregnant, the safety data advises against betaine hydrochloride. For protease, phytase, and lipase, there isn't enough data to know if they're safe in pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice before use.

Phytase has rare reports of allergic reactions in people with occupational exposure; protease similarly can rarely trigger allergic responses.

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start VegZymes, double-check any H2-blockers, antacids, or proton pump inhibitors (PPIs) you're on — betaine hydrochloride may weaken their effects. No interactions are documented for the other active ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

VegZymes is for people looking to support general digestion with a broad-spectrum enzyme blend. If you take acid-reducing medications (H2-blockers, antacids, or PPIs), check with us or your pharmacist first — betaine hydrochloride may reduce how well they work.

The same goes if you have a history of ulcers or acid reflux. And if you're pregnant or breastfeeding, run it past your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VegZymes, straight from the product label.

Brand BiOptimizers
Barcode (UPC) 0689176916614
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334481
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VegZymes by BiOptimizers, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
60
UPC/BARCODE
0689176916614
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Beta-Glucanase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Betaine Hydrochloride10 mg--
Cellulase0 NP--
InnoSlim45 mg--
Lipase, Fungal0 NP--
AstraZyme35 mg--
Enzyme Blend68.58 mg--
Cellulase0 NP--
Lipase Blend20 mg--
Pectinase S0 NP--
Protease FNP0 NP--
Protease Blend33.56 mg--

Other ingredients: Rice extract, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

VegZymes is an advanced enzyme formulation designed to aid digestion on a plant-based diet. Each vegan-friendly capsule contains a unique blend of 17 enzymes to assist in the breakdown of fibers, starches, sugars, fats, and proteins. These full spectrum enzymes are designed to be taken with your plant-based meals or protein shakes.

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules with each meal. (May take 1-3 capsules with each meal and 1-2 capsules between meals.)

Storage

Store in a cool/dry location.

Precautions

Caution: Keep out of reach of children.

Do not use if ulcer or gastritis are present. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement.

To report a serious adverse event, or obtain product information, contact 1(800) 719-2467 or visit: BiOptimizers.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Optimized digestive solutions

Vegan

Gluten-free Soy-free

Supports plant-based digestion

FDA Statement of Identity

Dietary Supplement

See for yourself

VegZymes by BiOptimizers label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in VegZymes by BiOptimizers

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
10 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

InnoSlim

45 mg per serving

AstraZyme

35 mg per serving

Enzyme Blend

68.58 mg per serving
  • › Amylase
  • › Alpha-Galactosidase
  • › Xylanase
  • › Beta-Glucanase
  • Phytase
  • › Hemicellulase
  • › Cellulase
  • › Cellulase
  • › Pectinase S
  • Protease FNP

Lipase Blend

No known
interactions
20 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase Blend monograph & interactions

Protease Blend

Interacts with
2 drugs
33.56 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Protease Blend monograph & interactions

Other (inactive) ingredients: Rice extract, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

VegZymes by BiOptimizers Drug Interactions

Want to check YOUR meds against VegZymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in VegZymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D

Protease Blend1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for VegZymes, from the product label.

BiOptimizers

See all BiOptimizers products
Name
BiOptimizers USA Inc.
Street Address
5470 Kietzke Lane, Suite 300
City
Reno
State
NV
ZipCode
89511
Phone Number
1 (800) 719-2467
Pharmacist Counseling Corner

VegZymes by BiOptimizers: Common Questions

Does VegZymes by BiOptimizers interact with any medications?
Yes. Based on its ingredients, VegZymes has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VegZymes contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help with digestion?
The evidence isn't established in our data. Lipase and phytase have been studied for digestive issues like dyspepsia and inflammatory bowel disease, but the research so far is insufficient to say whether they work. Your own results may vary.
Can I take this if I'm pregnant?
Betaine hydrochloride should be avoided in pregnancy — there isn't enough safety data. For protease, lipase, and phytase, there also isn't enough information to know either way. Talk with your doctor or pharmacist before taking it while pregnant.
Is it safe to breastfeed while taking this?
Safety data during breastfeeding is limited for most of these enzymes. Betaine hydrochloride is best avoided. Check with your healthcare provider first before using any ingredient in this formula while breastfeeding.
Can this cause side effects?
Most people tolerate it well, but protease and lipase may trigger digestive upset or allergic reactions in some. Betaine hydrochloride can irritate your stomach and cause heartburn, especially if you've had ulcers or acid reflux. Occupational exposure to protease and phytase has rarely caused allergic responses, though this is unlikely with oral supplements.
What's betaine hydrochloride doing in a digestive enzyme formula?
Betaine hydrochloride increases stomach acid to help your digestive system break down food. But if you take acid-reducing medications or have ulcers or gastritis, it can work against those treatments or irritate your stomach, so you'll want to check with your pharmacist first.
Are there any fillers in this?
Yes — it contains rice extract, cellulose, and water as inactive ingredients alongside the 16 active enzymes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if VegZymes is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VegZymes label
Go deeper

The Full Monographs Behind VegZymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

VegZymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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