Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Wahoo Ingredients & Drug Interactions

by Hawaii Pharm

Wahoo label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wahoo against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Wahoo is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for constipation (traditional laxative), digestive complaints, liver and gallbladder support (folk use).Based on those ingredients, 133 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Wahoo Bark Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wahoo by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Wahoo by Hawaii Pharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Wahoo by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Wahoo Bark Extract, Dry. The inactive ingredients are alcohol, water, and glycerin, which serve as the liquid base and preservative.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wahoo product and its label doesn't state a use — see Wahoo's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

No effectiveness ratings are on file for wahoo in our data. The evidence for what it may do is not established here.

The evidence, ingredient by ingredient Wahoo

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wahoo is considered poisonous and can cause serious, even life-threatening effects. The safety data advises against its use, and the plant contains toxic compounds.

Ingestion has been linked to severe upset stomach, sometimes with bloody diarrhea, fever, shortness of breath, circulatory problems, signs of collapse, loss of consciousness, muscle spasms, locked jaw, and coma — often starting several hours after exposure. It's also not safe in pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Wahoo

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wahoo.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 133 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Do not use this product if you take digoxin (Lanoxin) — it's contraindicated. If you take diuretics, stimulant laxatives, macrolide or tetracycline antibiotics, or quinine, speak with your pharmacist before use.

Better yet, ask about alternatives; wahoo's safety profile makes it hard to recommend at all.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

We can't recommend wahoo. The safety data advises against it altogether because of its serious toxicity risk.

If you're considering any herbal product for a health concern, talk with your pharmacist or doctor about safer, better-studied options.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wahoo, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253654618
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301961
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wahoo by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253654618
IngredientAmount% DV
Wahoo Bark Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Euonymus atropurpureus

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wahoo by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wahoo label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wahoo by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wahoo Bark Extract, Dry

Interacts with
133 drugs
983 mg per serving

Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a real risk...

Wahoo Bark Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wahoo by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Wahoo?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
133Drugs
1 Major 132 Moderate

Ingredients driving the most interactions

Wahoo Bark Extract, Dry 133

Individual Drug Interactions

The ingredients in Wahoo interact with 133 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wahoo interact with drugs. Each result below shows which ingredient is responsible. Wahoo Bark Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Wahoo with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wahoo Bark Extract, Dry6 drug types · 133 drugs

Digoxin (Lanoxin)

Contraindicated; using wahoo with digoxin increases risk of cardiac glycoside toxicity due to therapeutic duplication.

Likelihood Likely Evidence D
Diuretic Drugs

Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Macrolide Antibiotics

Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Likelihood Possible Evidence D
Quinine

Theoretically, concomitant use of quinine and wahoo might increase risk of cardiac toxicity.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, use of stimulant laxatives with wahoo might have additive laxative effects, and can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Likelihood Possible Evidence D
Wahoo Bark Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wahoo, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Wahoo by Hawaii Pharm: Common Questions

Does Wahoo by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Wahoo has a known interaction with 133 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wahoo contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is wahoo safe to take?
No. Wahoo is considered poisonous and can cause serious, even life-threatening effects. The safety data advises against its use entirely. Ingestion can cause severe upset stomach, bloody diarrhea, fever, shortness of breath, circulatory collapse, muscle spasms, and coma.
Can I take wahoo if I'm pregnant or breastfeeding?
No. Wahoo is rated likely unsafe in pregnancy and lactation and has historically been linked to uterine stimulation. Don't use it if you're pregnant or nursing.
Can I use wahoo with my heart medication?
If you take digoxin (Lanoxin), absolutely not — this combination is contraindicated and dangerous. Even if you take other heart or blood pressure medications, speak with your pharmacist or doctor first. Better yet, ask about safer alternatives; wahoo's toxicity makes it unsuitable for most people.
What does wahoo do?
We don't have effectiveness data on file for wahoo. Given its serious safety concerns, there are likely safer, better-studied options for whatever you're trying to address.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wahoo is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wahoo label
Go deeper

The Full Monographs Behind Wahoo’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wahoo

Interacts with 133 drugs

Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a real risk of serious harm. Because it contains hea...

Read the full Wahoo monograph →
Sources

Sources & How We Checked

Wahoo's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wahoo 4 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

See these in context on the Wahoo monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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