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Dietary supplement

White Mulberry Leaf Extract Ingredients & Drug Interactions

by NusaPure

White Mulberry Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking White Mulberry Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

White Mulberry Leaf Extract is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Mulberry leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against White Mulberry Leaf Extract by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with White Mulberry Leaf Extract by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of White Mulberry Leaf Extract by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf extract. It's paired with inactive ingredients — cellulose, silica, magnesium stearate, and rice powder — which serve as capsule filler and binder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: blood sugar and cholesterol support.
  • We looked for evidence on: Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes), metabolic health, cardiovascular health.
  • The closest evidence on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Impaired glucose tolerance (prediabetes).

The effectiveness data we hold shows insufficient reliable evidence to rate white mulberry leaf for the conditions studied: androgenic alopecia (hair loss), osteoporosis, common cold, diabetes, and high cholesterol (hyperlipidemia). That means the clinical evidence isn't robust enough yet to say whether it works for these uses — not that it definitely doesn't.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken orally. The most common side effects are mild digestive issues: bloating, gas, loose stools, and constipation.

One clinical trial found these affected a meaningful number of participants early on — about half experienced bloating or gas, a quarter had loose stools, and a fifth had constipation — but the good news is these effects often faded over the course of treatment. There isn't enough safety data to recommend this supplement during pregnancy or while breastfeeding.

The safety information we hold advises against medicinal amounts in both cases. Because the supplement can lower blood sugar, use caution if you're at risk for low blood glucose.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take NusaPure White Mulberry Leaf Extract, double-check with your pharmacist if you take antidiabetes drugs (insulin, metformin, sulfonylureas) or any OCT2 substrate medications. Altogether, these interactions span 86 individual medications.

If you're on blood sugar–lowering therapy, close glucose monitoring is essential.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

White mulberry leaf extract might appeal to you if you're interested in blood sugar support or cholesterol management, but the evidence for these uses hasn't been firmly established yet. If you take antidiabetes medications or drugs cleared through the kidney's OCT2 transporter, talk with your pharmacist before starting — the blood sugar interaction is real and needs monitoring.

Same goes for pregnancy and breastfeeding: check with your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about White Mulberry Leaf Extract, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O7YOQP
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 247129
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for White Mulberry Leaf Extract by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
200
UPC/BARCODE
X001O7YOQP
IngredientAmount% DV
White Mulberry leaf extract500 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule once daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Assembled in USA Natural Supports healthy glucose levels Supports healthy appetite control Herbal antioxidant support Max Strength

Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients.

Storage

Store in a cool, dry place after opening.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

Formula

White Mulberry leaf extract 2500 mg equivalent per capsule

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

White Mulberry Leaf Extract by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

White Mulberry Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in White Mulberry Leaf Extract by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

White Mulberry leaf extract

Interacts with
87 drugs
500 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

White Mulberry leaf extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

White Mulberry Leaf Extract by NusaPure Drug Interactions

Want to check YOUR meds against White Mulberry Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

White Mulberry leaf extract 87

Individual Drug Interactions

The ingredients in White Mulberry Leaf Extract interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in White Mulberry Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. White Mulberry leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in White Mulberry Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

White Mulberry leaf extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
White Mulberry leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for White Mulberry Leaf Extract, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

White Mulberry Leaf Extract by NusaPure: Common Questions

Does White Mulberry Leaf Extract by NusaPure interact with any medications?
Yes. Based on its ingredients, White Mulberry Leaf Extract has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
White Mulberry Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar if I don't have diabetes?
White mulberry leaf can lower blood glucose in general, so it's theoretically possible. The safety information we hold recommends caution because of this blood sugar–lowering effect. If you're not on diabetes medication and don't have blood sugar concerns, the risk is probably lower — but it's worth discussing with your pharmacist based on your individual health picture.
What are the most common side effects?
Digestive upset: bloating, gas, loose stools, and constipation. One trial found these in a decent number of people at the start, but they often eased up over time. The supplement itself seems well tolerated overall.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data, and the evidence we hold advises against medicinal amounts during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether this is right for you.
Does this actually work for high cholesterol or diabetes?
The clinical evidence we hold is insufficient to say either way. Studies haven't established reliable proof that it works for these conditions yet, so don't count on it as a primary treatment.
What's in the capsule besides the mulberry extract?
Cellulose, silica, magnesium stearate, and rice powder — these are fillers and binders that hold the capsule together. No hidden active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if White Mulberry Leaf Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

White Mulberry Leaf Extract label
Go deeper

The Full Monographs Behind White Mulberry Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

White Mulberry Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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