Interactions on record — worth a quick check against your medications. Based on 2 of 10 ingredients. Check your meds →
Dietary supplement

WholeMega Ingredients & Drug Interactions

by New Chapter

WholeMega label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking WholeMega against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

WholeMega is a dietary supplement by New Chapter with 10 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 743 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against WholeMega by New Chapter

Ask about any prescription or over-the-counter medication and we check it for interactions with WholeMega by New Chapter — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of WholeMega by New Chapter

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 12 of its 12 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 744 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 2 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about WholeMega, straight from the product label.

Brand New Chapter
Net contents 90 Softgel(s)
Market status Off market
Date entered into DSLD Nov 25, 2011
DSLD ID 2559
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for WholeMega by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
23
IngredientAmount% DV
Calories20 {Calories}, 5 {Calories}--
Calories from Fat18 {Calories}, 5 {Calories}--
Total Fat2000 mg, 500 mg3%, 1%
Eicosapentaenoic Acid180 mg, 45 mg--
Docosahexaenoic Acid220 mg, 55 mg--
Saturated Fat480 mg, 120 mg2%, 1%
Polyunsaturated Fat680 mg, 170 mg--
Cholesterol15 mg, 5 mg5%, 1%
Astaxanthin6 mcg, 1.5 mcg--
Monounsaturated Fat840 mg, 210 mg--
Total Omega-3 Fatty Acids500 mg, 125 mg--
Vitamin D100 IU, 25 IU25%, 6%
Myristoleic Acid1 mg, 0.25 mg--
Palmitoleic Acid100 mg, 25 mg--
Other Omega-3 Fatty Acids100 mg, 25 mg--
Total Omega-6 Fatty Acids140 mg, 35 mg--
Total Omega-9 Fatty Acids660 mg, 165 mg--

Other ingredients: Fish oil, Botanical Antioxidant Stability System, Mixed Tocopherols, Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Two softgels two times daily. For best results, take two softgels immediately before your two largest meals.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place. DO NOT REFRIGERATE.

General Statements

100% Wild Alaskan Salmon

500 mg

Before After

Easy to Swallow Omega-Rich Fish Oil

EPA DHA

Nature’s Whole Complement of Sixteen Omegas – 3, 5, 6, 7 and 9’s • Bioavailable: Clinically Shown to Enter Cell Membranes for Optimal Fish Oil Benefits • Effective: Reduces Inflammatory Arachidonic Acid* • Whole: Natural Source of Omegas + Vitamin D + Astaxanthin

NEW

Omega-3 ng/1 x 106 cells

Patent Pending

Please help protect our planet – recycle this bottle and box after use.

This package is made of 100% recycled paperboard (35% post- consumer content). It is processed chlorine-free (PCF) and uses vegetable oil-based inks.

Precautions

If you are nursing, pregnant, or considering pregnancy, you should consult your health care practitioner prior to using this product.

Caution: As with any dietary or herbal supplement, you should advise your health care practitioner of the use of this product.

Brand IP Statement(s)

Clearly Different: Coventional Fish Oil Wholemega(TM)

Nature’s Whole Complement of Sixteen Omegas – 3, 5, 6, 7 and 9 Fatty Acids A Whole New Approach To Fish Oil New Chapter(R) is proud to offer a whole-food approach to fish oil and an alternative to the fractionated, highly processed and “purified” oils on the market today. From the pristine, protected waters of Alaska directly to you, Wholemega is 100% wild-caught salmon oil; rigorously tested to ensure each capsule delivers Nature’s bioavailable, effective, and whole profile of beneficial fatty acids and nutrients. Omega Oils & Optimal Health Natural salmon oil contains a balance of vital Omega 3, 5, 6, 7 and 9’s, often referred to as “good fats.” These good fats, which include two essential fatty acids the human body cannot produce on its own, serve to nourish brain, heart, eye, and kidney tissues.* They have been shown to benefit cardiovascular, immune system, brain, and digestive health.*

The Benefits of Whole Wholemega(TM) is a true expression of nature’s wisdom. By using only sustainably caught Alaskan salmon – among the world’s cleanest and most pure fish stocks – an extra virgin, low heat process is all that’s required to deliver nature’s intelligence and the whole complement of omega fatty acids, while still guaranteeing optimal purity. “Food Grade” Wholemega oil is extensively tested for detectable PCBs, heavy metal contaminants, and toxins that must be distilled out of other fish oils. Effectiveness For optimal benefit, fish oil must be incorporated into cell membranes, where it serves to modulate cell signal events (e.g. modulate inflammation) and increases membrane fluidity.* As demonstrated in a human clinical trial, Wholemega has been shown to incorporate into peripheral blood mononuclear cells (PBMCs) – allowing fish oil to provide its beneficial effects. Additionally, Wholemega has been shown to down-regulate inflammatory arachidonic acid (AA); significantly improving the balance of inflammatory AA to anti-inflammatory EPA.* Preliminary data also shows Wholemega may down-regulate inflammatory markers, such as LDL (“bad”) cholesterol and C-Reactive Protein.* A human clinical study (see chart) demonstrates the change of essential fatty acid content (EPA & DHA) in cell membranes (PBMC) after consuming Wholemega:

The Difference Is Clear The dull, yellow hue of conventional fish oils is symbolic of “purified” products. In the heavy processing required for aging or tainted fish stocks (to remove toxins, PCBs, heavy metals, etc.), many beneficial compounds that give fresh fish oil its vibrant color can be destroyed and lost forever. Wholemega, however, delivers an oil that is striking in color – similar to what you’d see in the whole salmon fillets found in any natural fish market. The brilliant hue in Wholemega comes from Astaxanthin – an extremely powerful antioxidant that is naturally found in wild salmon and abundant in this extra virgin fish oil. The gentle process used to extract Wholemega preserves this antioxidant as well as numerous other beneficial compounds – including Vitamin D. In fact, this whole oil is delivered from a government inspected FOOD GRADE facility.

Formulation

Naturally gluten free.

Our premium softgel capsules are prepared without any chemical solvents and are prion free.

Seals/Symbols

100% Sustainably Wild-Caught Salmon

HEART HEALTHY

Purple Loves Green(TM)NewChapter(R)

WHOLEmega(TM)

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

WholeMega by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

WholeMega label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in WholeMega by New Chapter

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

180 mg per serving

Docosahexaenoic Acid

220 mg per serving

Astaxanthin

Interacts with
671 drugs
6 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega-3 Fatty Acids

500 mg per serving

Vitamin D

Interacts with
715 drugs
100 IU per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Myristoleic Acid

1 mg per serving

Palmitoleic Acid

100 mg per serving

Other Omega-3 Fatty Acids

100 mg per serving Form: Docosapentaenoic Acid, Heneicosapentaenoic Acid, Linolenic Acid

Total Omega-6 Fatty Acids

140 mg per serving Form: Arachidonic Acid, Linoleic Acid, Octadecatetraenoic Acid

Total Omega-9 Fatty Acids

660 mg per serving Form: Eicosatetraenoic Acid, Erucic Acid, Gadoleic Acid, Margaroleic Acid, Nervonic Acid, Oleic Acid

Other (inactive) ingredients: Fish oil, Botanical Antioxidant Stability System, Mixed Tocopherols, Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

WholeMega by New Chapter Drug Interactions

WholeMega contains 10 ingredients, and 2 of them have known drug interactions. Altogether they interact with 743 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against WholeMega?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
743Drugs
743 Moderate

Ingredients driving the most interactions

Vitamin D 715
Astaxanthin 671

Individual Drug Interactions

The ingredients in WholeMega interact with 743 drugs. Click any drug to see the details.

2 of the 10 ingredients in WholeMega interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in WholeMega with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for WholeMega, from the product label.

New Chapter

See all New Chapter products
Web Address
newchapter.com
Pharmacist Counseling Corner

WholeMega by New Chapter: Common Questions

Does WholeMega by New Chapter interact with any medications?
Yes. Based on its ingredients, WholeMega has a known interaction with 743 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
WholeMega contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if WholeMega is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

WholeMega label
Go deeper

The Full Monographs Behind WholeMega’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph →
Sources

Sources & How We Checked

WholeMega's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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