Busulfan

18 interactions 1 explained in plain English
Also sold as: Busulfex Myleran
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Injection Methotrexate Methotrexate Injection Metronidazole Mercaptopurine Metronidazole Topical
14 Major 4 Moderate
All (18) Major (14) Moderate (4)

Major

Busulfan Azathioprine Azasan An increased risk of hepatotoxicity Details Busulfan Blinatumomab Injection Blincyto Increased busulfan exposure Details Busulfan Deferasirox Exjade Increased busulfan exposure Details Busulfan Deferiprone Ferriprox Increased busulfan exposure Details Busulfan Deferoxamine Increased busulfan exposure Details Busulfan Hydroxychloroquine Plaquenil An increased risk of seizures Details Busulfan Ketoconazole Topical Extina® Foam Increased busulfan exposure Details Busulfan Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Busulfan Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Busulfan Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Busulfan Metronidazole Flagyl Increased busulfan exposure and an increased risk of busulfan toxicity Details Busulfan Metronidazole Injection Flagyl Increased busulfan exposure and an increased risk of busulfan toxicity Details Busulfan Metronidazole Topical MetroCream® Increased busulfan exposure and an increased risk of busulfan toxicity Details Busulfan Metronidazole Vaginal MetroGel® Vaginal Increased busulfan exposure and an increased risk of busulfan toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.