Butorphanol

35 interactions 4 explained in plain English
Also sold as: Butorphic Dolorex Solution Torbugesic Torphadine Vetorphic
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Butorphanol Acetaminophen And Codeine Capital® & Codeine Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Butorphanol Amitriptyline Elavil Explained Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Sertraline Explained Increased risk of serotonin syndrome Details Butorphanol Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Butorphanol Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Butorphanol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Butorphanol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Butorphanol Clopidogrel Plavix Reduced efficacy of clopidogrel Details Butorphanol Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Butorphanol Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Butorphanol Diphenhydramine Injection Banophen Increased risk of respiratory and CNS depression Details Butorphanol Diphenhydramine Topical Afterbite with Antihistamine Increased risk of respiratory and CNS depression Details Butorphanol Dolasetron Anzemet Increased risk of serotonin syndrome Details Butorphanol Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Butorphanol Esketamine Nasal Spray Spravato Increased risk of sedation Details Butorphanol Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Butorphanol Granisetron Injection Granisol Increased risk of serotonin syndrome Details Butorphanol Hydromorphone Injection Dilaudid Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Hydromorphone Rectal available generically Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Hydroxychloroquine Plaquenil An increased risk of seizures Details Butorphanol Lacosamide Injection Motpoly An increased risk of CNS depression Details Butorphanol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Butorphanol Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Butorphanol Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Butorphanol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Butorphanol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Butorphanol Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Butorphanol Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details Butorphanol Morphine Injection Astramorph® PF Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.