Carisoprodol

25 interactions 3 explained in plain English

Also sold as: Soma Vanadom

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Diazepam Nasal Spray Midazolam Nasal Spray Butorphanol Injection Butorphanol Nasal Spray Glucagon Injection / Solution

24 Major 1 Moderate

All (25) Major (24) Moderate (1)

Major

Carisoprodol Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Carisoprodol Amitriptyline Elavil Explained An increased risk of sedation Details Carisoprodol Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action, an increased risk of respiratory depression and CNS depression and an increased risk of pa... Details Carisoprodol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Carisoprodol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Carisoprodol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Carisoprodol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Carisoprodol Diazepam Nasal Spray Valtoco Additive respiratory depression Details Carisoprodol Diazepam Rectal Diastat Additive respiratory depression Details Carisoprodol Esketamine Nasal Spray Spravato Increased risk of sedation Details Carisoprodol Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of profound sedati... Details Carisoprodol Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Carisoprodol Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Carisoprodol Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Carisoprodol Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Carisoprodol Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Carisoprodol Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Carisoprodol Lacosamide Injection Motpoly An increased risk of CNS depression Details Carisoprodol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Carisoprodol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Carisoprodol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Carisoprodol Midazolam Nasal Spray Nayzilam Additive respiratory depression Details Carisoprodol Midazolam Injection Nayzilam Additive respiratory depression Details Carisoprodol Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus, an increased risk of profound sedation, hypotension... Details

Moderate

Carisoprodol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.