Cyclothiazide

46 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meclofenamate Naproxen Buprenorphine Meloxicam Injection Fentanyl Transdermal Patch Aspirin

34 Major 12 Moderate

All (46) Major (34) Moderate (12)

Major

Cyclothiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Cyclothiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Cyclothiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Cyclothiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Cyclothiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Cyclothiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Cyclothiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Cyclothiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Cyclothiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Cyclothiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Cyclothiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Cyclothiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclothiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Cyclothiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Cyclothiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Cyclothiazide Benazepril Lotensin Reduction of blood pressure Details Cyclothiazide Captopril Capoten® Reduction of blood pressure Details Cyclothiazide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Cyclothiazide Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.