Ethacrynic Acid

57 interactions 4 explained in plain English
Also sold as: Edecrin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Naproxen Ketorolac Nasal Spray Ketoprofen Amikacin Oral Inhalation Flurbiprofen
1 Contraindicated 41 Major 15 Moderate
All (57) Contraindicated (1) Major (41) Moderate (15)

Moderate

Ethacrynic Acid Lisinopril Prinivil Explained Postural hypotension (first dose) Details Ethacrynic Acid Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Ethacrynic Acid Benazepril Lotensin Postural hypotension (first dose) Details Ethacrynic Acid Captopril Capoten® Postural hypotension (first dose) Details Ethacrynic Acid Digoxin Cardoxin® Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Ethacrynic Acid Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Ethacrynic Acid Enalapril Epaned Postural hypotension (first dose) Details Ethacrynic Acid Fludrocortisone Acetate Florinef® Hypokalemia (lethargy, muscle weakness, cardiac arrhythmias) Details Ethacrynic Acid Fosinopril Monopril® Postural hypotension (first dose) Details Ethacrynic Acid Hydrocortisone Ala-Cort Hypokalemia Details Ethacrynic Acid Hydrocortisone Injection A-Hydrocort® Hypokalemia Details Ethacrynic Acid Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Ethacrynic Acid Moexipril Univasc® Postural hypotension (first dose) Details Ethacrynic Acid Olodaterol Oral Inhalation Striverdi An increased risk of ECG changes and/or an increased risk of hypokalemia Details Ethacrynic Acid Perindopril Aceon Postural hypotension (first dose) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.