Gabapentin

27 interactions 2 explained in plain English

Also sold as: Gabarone Gralise Horizant Neurontin Relgaabi

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Buprenorphine Esketamine Nasal Spray Fentanyl Transdermal Patch Orlistat Hydromorphone Rectal

25 Major 2 Moderate

All (27) Major (25) Moderate (2)

Major

Gabapentin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Gabapentin Aripiprazole Injection Abilify An increased risk of respiratory depression and sedation Details Gabapentin Asenapine Transdermal Patch Secuado An increased risk of respiratory depression and sedation Details Gabapentin Butorphanol Injection Butorphic An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Butorphanol Nasal Spray Stadol® NS An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Calcifediol Rayaldee Altered serum levels of calcifediol Details Gabapentin Cetirizine Injection Aller-Tec An increased risk of respiratory depression and sedation Details Gabapentin Cetirizine Ophthalmic Zerviate An increased risk of respiratory depression and sedation Details Gabapentin Diazepam Nasal Spray Valtoco An increased risk of respiratory depression and sedation Details Gabapentin Diazepam Rectal Diastat An increased risk of respiratory depression and sedation Details Gabapentin Diphenhydramine Injection Banophen An increased risk of respiratory depression and sedation Details Gabapentin Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory depression and sedation Details Gabapentin Esketamine Nasal Spray Spravato An increased risk of respiratory depression and sedation Details Gabapentin Fentanyl Transdermal Patch Duragesic® An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Hydromorphone Injection Dilaudid An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Hydromorphone Rectal available generically An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Gabapentin Lacosamide Injection Motpoly An increased risk of CNS depression Details Gabapentin Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Gabapentin Midazolam Nasal Spray Nayzilam An increased risk of respiratory depression and sedation Details Gabapentin Midazolam Injection Nayzilam An increased risk of respiratory depression and sedation Details Gabapentin Morphine Injection Astramorph® PF An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Nalbuphine Injection Nubain® An increased risk of serious and/or fatal respiratory depression and sedation Details Gabapentin Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Gabapentin Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Gabapentin Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.